Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review
Abstract
:1. Introduction
2. Methods
3. Results
4. Representative Clinical Case
5. Discussion
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Corneal Neurotization With a Great Auricular Nerve Graft: Effective Reinnervation Demonstrated by In Vivo Confocal Microscopy | Benkhatar H, Levy O, Goemaere I, Borderie V, Laroche L, Bouheraoua N | Cornea | 2018 |
Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation | Catapano J, Fung SSM, Halliday W, Jobst C, Cheyne D, Ho ES, Zuker RM, Borschel GH, Ali A | Br J Ophthalmol | 2019 |
Corneal Neurotization via Dual Nerve Autografting | Charlson ES, Pepper JP, Kossler AL | Ophthalmic Plast Reconstr Surg | 2022 |
Corneal Neurotization: A Review of Pathophysiology and Outcomes | Park JK, Charlson ES, Leyngold I, Kossler AL | Ophthalmic Plast Reconstr Surg | 2020 |
Corneal Neurotization: A Meta-analysis of Outcomes and Patient Selection Factors | Swanson MA, Swanson RD, Kotha VS, Cai Y, Clark R, Jin A, Kumar AR, Davidson EH | Ann Plast Surg | 2022 |
In Vivo and Ex Vivo Comprehensive Evaluation of Corneal Reinnervation in Eyes Neurotized With Contralateral Supratrochlear and Supraorbital Nerves | Giannaccare G, Bolognesi F, Biglioli F, Marchetti C, Mariani S, Weiss JS, Allevi F, Cazzola FE, Ponzin D, Lozza A, Bovone C, Scorcia V, Busin M, Campos EC | Cornea | 2020 |
CORNEAL NEUROTIZATION IN A PATIENT WITH SEVERE NEUROTROPHIC KERATOPATHY. CASE REPORT | Rusňák Š, Hecová L, Štěpánek D, Sobotová M | Cesk Slov Oftalmol | 2021 |
Minimally invasive, indirect corneal neurotization using an ipsilateral sural nerve graft for early neurotrophic keratopathy | Lee BWH, Khan MA, Ngo QD, Tumuluri K, Samarawickrama C | Am J Ophthalmol Case Rep | 2022 |
Corneal neurotization from the supratrochlear nerve with sural nerve grafts: a minimally invasive approach | Bains RD, Elbaz U, Zuker RM, Ali A, Borschel GH | Plast Reconstr Surg | 2015 |
Direct Neurotization: Past, Present, and Future Considerations | Horen SR, Hamidian Jahromi A, Konofaos P | Ann Plast Surg | 2022 |
Corneal neurotization | Koaik M, Baig K | Curr Opin Ophthalmol | 2019 |
Corneal Neurotization-Indications, Surgical Techniques and Outcomes | Dragnea DC, Krolo I, Koppen C, Faris C, Van den Bogerd B, Ní Dhubhghaill S | J Clin Med | 2023 |
Corneal neurotization in the management of neurotrophic keratopathy: A review of the literature | Saad S, Labani S, Goemaere I, Cuyaubere R, Borderie M, Borderie V, Benkhatar H, Bouheraoua N | J Fr Ophtalmol | 2023 |
Korneale Neurotisation | Lueke JN, Holtmann C, Beseoglu K, Geerling G | Ophthalmologe | 2020 |
Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes | Liu CY, Arteaga AC, Fung SE, Cortina MS, Leyngold IM, Aakalu VK | Ocul Surf | 2021 |
Corneal Neurotization: Review of a New Surgical Approach and Its Developments | Wolkow N, Habib LA, Yoon MK, Freitag SK | Semin Ophthalmol | 2019 |
Seeing through the evidence for corneal neurotization | Jowett N, Pineda R 2nd | Curr Opin Otolaryngol Head Neck Surg | 2021 |
Bilateral Corneal Neurotization for Ramos-Arroyo Syndrome and Developmental Neurotrophic Keratopathy: Case Report and Literature Review | Rowe LW, Berns J, Boente CS, Borschel GH | Cornea | 2023 |
Corneal Neurotization: Preoperative Patient Workup and Surgical Decision-making | Daeschler SC, Woo JH, Hussein I, Ali A, Borschel GH | Plast Reconstr Surg Glob Open | 2023 |
Clinical outcomes of corneal neurotization using sural nerve graft in neurotrophic keratopathy | Saini M, Kalia A, Jain AK, Gaba S, Malhotra C, Gupta A, Soni T, Saini K, Gupta PC, Singh M | PLoS One | 2023 |
Corneal Neurotization Using the Great Auricular Nerve for Bilateral Congenital Trigeminal Anesthesia | Lau N, Osborne SF, Vasquez-Perez A, Wilde CL, Manisali M, Jayaram R | Cornea | 2022 |
Herpetic Corneal Keratopathy Management Using Ipsilateral Supratrochlear Nerve Transfer for Corneal Neurotization | Lin CH, Lai LJ | Ann Plast Surg | 2019 |
Minimally-Invasive Corneal Neurotization (MICN): 10 Year Update in Technique and Lessons Learned Including Novel Donor Transfer of the Great Auricular Nerve | Gross JN, Bhagat N, Tran K, Liu S, Boente CS, Ali A, Borschel GH | Plast Reconstr Surg | 2023 |
Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft: Surgical Technique and Clinical Outcomes | Leyngold IM, Yen MT, Tian J, Leyngold MM, Vora GK, Weller C | Ophthalmic Plast Reconstr Surg | 2019 |
Endoscopic Corneal Neurotization: Technique and Initial Experience | Leyngold I, Weller C, Leyngold M, Tabor M | Ophthalmic Plast Reconstr Surg | 2018 |
Neurotization of the human cornea—A comprehensive review and an interim report | Rathi A, Bothra N, Priyadarshini SR, Achanta DSR, Fernandes M, Murthy SI, Kapoor AG, Dave TV, Rath S, Yellinedi R, Nuvvula R, Dendukuri G, Naik MN, Ramappa M | Indian J Ophthalmol | 2022 |
Acellular nerve allografts in corneal neurotisation: an inappropriate choice | Jowett N, Pineda Ii R | Br J Ophthalmol | 2020 |
The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study | Kikuta S, Yalcin B, Iwanaga J, Watanabe K, Kusukawa J, Tubbs RS | Anat Cell Biol | 2020 |
Neurotrophic Keratitis in a Pediatric Patient With Goldenhar Syndrome and Trigeminal Aplasia Successfully Treated by Corneal Neurotization | Rollon-Mayordomo A, Mataix-Albert B, Espejo-Arjona F, Herce-Lopez J, Lledo-Villar L, Caparros-Escudero C, Infante-Cossio P | Ophthalmic Plast Reconstr Surg | 2022 |
Anatomic characteristics of supraorbital and supratrochlear nerves relevant to their use in corneal neurotization | Domeshek LF, Hunter DA, Santosa K, Couch SM, Ali A, Borschel GH, Zuker RM, Snyder-Warwick AK | Eye (Lond) | 2019 |
The Second Division of Trigeminal Nerve for Corneal Neurotization: A Novel One-Stage Technique in Combination With Facial Reanimation | Gennaro P, Gabriele G, Aboh IV, Cascino F, Menicacci C, Mazzotta C, Bagaglia S | J Craniofac Surg | 2019 |
Lateral Antebrachial Cutaneous Nerve as Autologous Graft for Mini-Invasive Corneal Neurotization (MICORNE) | Bourcier T, Henrat C, Heitz A, Kremer SF, Labetoulle M, Liverneaux P | Cornea | 2019 |
Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy | Jowett N, Pineda Ii R | Br J Ophthalmol | 2019 |
Corneal neurotization with a great auricular nerve graft: effective reinnervation demonstrated by in vivo confocal microscopy | Benkhatar H, Levy O, Goemaere I, Borderie V, Laroche L, Bouheraoua N | Cornea | 2018 |
Outcomes of corneal neurotisation using processed nerve allografts: a multicentre case series | Sweeney AR, Wang M, Weller CL, Burkat C, Kossler AL, Lee BW, Yen MT | Br J Ophthalmol | 2022 |
Authors | Year | Type of Study | Patients | Eyes | Mean Age | Direct | Indirect | Donor Nerve | Nerve Graft | Type of Coaptation | Technique |
---|---|---|---|---|---|---|---|---|---|---|---|
Benkhatar H, Levy O, Goemaere I, Borderie V, Laroche L, Bouheraoua N. | 2018 | Case Report | 1 | 1 | 58 | ✓ | - | Ipsilateral Great Auricular | - | - | Open |
Charlson ES, Pepper JP, Kossler AL. | 2022 | Case Report | 1 | 1 | - | ✓ | Contralateral Supraorbital + Supratrochlear | Dual Sural | E-E | Open | |
Giannaccare G, Bolognesi F, Biglioli F, Marchetti C, Mariani S, Weiss JS, Allevi F, Cazzola FE, Ponzin D, Lozza A, Bovone C, Scorcia V, Busin M, Campos EC | 2020 | Case Series | 3 | 3 | 61 | ✓ | - | Contralateral Supraorbital and/or Contralateral Supratrochlear | - | - | Open |
Rusňák Š, Hecová L, Štěpánek D, Sobotová M. | 2021 | Case Report | 1 | 1 | 22 | - | ✓ | Contralateral Supraorbital | Sural | E-E | Open |
Lee BWH, Khan MA, Ngo QD, Tumuluri K, Samarawickrama C. | 2022 | Case Report | 1 | 1 | 11 | - | ✓ | Ipsilateral Supratrochlear | Sural | E-E | Open |
Rowe LW, Berns J, Boente CS, Borschel GH. | 2023 | Case Report + Literarature Review | 1 | 2 | 17 | - | ✓ | Great Auricular | Sural | E-E | Open |
Lau N, Osborne SF, Vasquez-Perez A, Wilde CL, Manisali M, Jayaram R. | 2022 | Case Report | 1 | 2 | 4 | - | ✓ | Great Auricular | Sural | E-E | Open |
Lin CH, Lai LJ. | 2019 | Case Series | 13 | 13 | 61,8 | ✓ | - | Ipsilateral Supratrochlear | - | - | Open |
Leyngold IM, Yen MT, Tian J, Leyngold MM, Vora GK, Weller C. | 2019 | Case Series | 7 | 7 | 46 | - | ✓ | Supratrochlear (5) Supraorbital (1) Infraorbital (1) | Acellular Allograft | E-E E-E E-S | Open |
Leyngold I, Weller C, Leyngold M, Tabor M. | 2018 | Case Report | 1 | 1 | 83 | ✓ | - | Contralateral Supraorbital | - | - | Endoscopic |
Rollon-Mayordomo A, Mataix-Albert B, Espejo-Arjona F, Herce-Lopez J, Lledo-Villar L, Caparros-Escudero C, Infante-Cossio P. | 2022 | Case Report | 1 | 1 | 6 | - | ✓ | Contralateral Supratrochlear | Sural | E-E | Open |
Bourcier T, Henrat C, Heitz A, Kremer SF, Labetoulle M, Liverneaux P. | 2019 | Case Report | 1 | 1 | 32 | - | ✓ | Contralateral Supraorbital | Lateral Antebrachial Cutaneous | E-E | Open |
Sweeney AR, Wang M, Weller CL, Burkat C, Kossler AL, Lee BW, Yen MT. | 2022 | Case Series | 17 | 17 | 42,6 | - | ✓ | Ipsilateral or Contralateral Supratrochlear or Supraorbital | Acellular Allograft | E-E | Open |
Gennaro P, Gabriele G, Aboh IV, Cascino F, Menicacci C, Mazzotta C, Bagaglia S. | 2019 | Case Report | 1 | 1 | 58 | ✓ | - | Ipsilateral Infraorbital | - | - | Open |
Benkhatar H, Levy O, Goemaere I, Borderie V, Laroche L, Bouheraoua N. | 2018 | Case Report | 1 | 1 | 58 | - | ✓ | Supratrochlear | Great Auricular | E-E | Open |
Choice of the Donor Nerve: Variables and Factors to Be Considered. |
---|
Sensory integrity (peripheral/central trigeminal disease) |
Nerve caliber |
Axon count |
Anatomical vicinity |
NK severity |
Previous surgeries |
Unilateral or bilateral cornea anesthesia |
Surgical accessibility |
Surgeon’s expertise |
Surgeon’s preference |
Factors Influencing Surgical Outcome | |
---|---|
Positive | Negative |
B vitamins in the diet | Age |
End to end coaptation | Time since denervation * |
Caliber of donor nerve | Distance of graft coaptation |
Autologous graft | Smoking |
Diabetes | |
Allograft |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Serra, P.L.; Giannaccare, G.; Cuccu, A.; Bolognesi, F.; Biglioli, F.; Marcasciano, M.; Tarabbia, F.; Pagliara, D.; Figus, A.; Boriani, F. Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review. J. Clin. Med. 2024, 13, 2268. https://doi.org/10.3390/jcm13082268
Serra PL, Giannaccare G, Cuccu A, Bolognesi F, Biglioli F, Marcasciano M, Tarabbia F, Pagliara D, Figus A, Boriani F. Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review. Journal of Clinical Medicine. 2024; 13(8):2268. https://doi.org/10.3390/jcm13082268
Chicago/Turabian StyleSerra, Pietro Luciano, Giuseppe Giannaccare, Alberto Cuccu, Federico Bolognesi, Federico Biglioli, Marco Marcasciano, Filippo Tarabbia, Domenico Pagliara, Andrea Figus, and Filippo Boriani. 2024. "Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review" Journal of Clinical Medicine 13, no. 8: 2268. https://doi.org/10.3390/jcm13082268
APA StyleSerra, P. L., Giannaccare, G., Cuccu, A., Bolognesi, F., Biglioli, F., Marcasciano, M., Tarabbia, F., Pagliara, D., Figus, A., & Boriani, F. (2024). Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review. Journal of Clinical Medicine, 13(8), 2268. https://doi.org/10.3390/jcm13082268