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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Genetic Polymorphism of Zinc Transporter-8 Gene (SLC30A8), Serum Zinc Concentrations, and Proteome Profiles Related to Type 2 Diabetes in Elderly

by
Jintana Sirivarasai
1,*,
Pimvaree Tristitworn
2,
Prapimporn Chattranukulchai Shantavasinkul
3,
Sittiruk Roytrakul
4,
Sirintorn Chansirikarnjana
3,
Sirasa Ruangritchankul
3,
Suwannee Chanprasertyothin
5,
Piangporn Charernwat
3,
Pachara Panpunuan
3,
Thanyachai Sura
3 and
Piyamitr Sritara
3
1
Nutrition Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
2
Master of Science Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand
3
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
4
National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Pathum Thani 12120, Thailand
5
Research & Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(3), 790; https://doi.org/10.3390/jcm14030790
Submission received: 7 January 2025 / Revised: 20 January 2025 / Accepted: 24 January 2025 / Published: 25 January 2025
(This article belongs to the Special Issue Type 2 Diabetes: Advances and Challenges)
Versions Notes

Abstract

Background and Aims: Older adults are particularly susceptible to type 2 diabetes mellitus (T2DM) due to factors such as age-related insulin resistance, decreased physical activity, and deficiency of micronutrients, especially zinc. Studies have suggested that the risk allele of the zinc transporter 8 gene (SLC30A8) single-nucleotide poly-morphism (SNP) rs13266634 may contribute to T2DM susceptibility in addition to the complex protein interactions and alterations in the protein expressions and modifications associated with T2DM. This study was implemented to study the associations between SLC30A8 polymorphism, serum zinc levels, and the profiles of proteins differentially expressed in nondiabetic (n = 116) and prediabetic/diabetic (n = 149) subjects. Methods: SNP genotyping using TaqMan® assay and proteomic analysis by LC-MS/MS were performed in each group. Results: The results showed a higher risk of diabetes in individuals with the risk genotype CC accompanied by a low serum zinc level than in those with other genotypes. Profiles of proteins differentially expressed between the groups were identified and shown to be particularly associated with zinc-related functions, zinc transporter 8, and glucose metabolism. Proteins exclusively expressed in prediabetes/diabetes were assigned to a Reactome pathway related to zinc transporter and insulin processing. Conclusions: Our findings suggest that individuals carrying at least one copy of SLC30A8 rs13266634 accompanied by a low serum zinc level might be susceptible to T2DM, which could be due to alterations in insulin signaling and zinc metabolism. Understanding this relationship deepens our understanding of the genetic and molecular mechanisms underlying T2DM risk, offering potential targets for therapeutic intervention and prevention strategies.
Keywords: zinc transporter; genetic polymorphism; proteomics; type 2 diabetes; elderly zinc transporter; genetic polymorphism; proteomics; type 2 diabetes; elderly

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MDPI and ACS Style

Sirivarasai, J.; Tristitworn, P.; Shantavasinkul, P.C.; Roytrakul, S.; Chansirikarnjana, S.; Ruangritchankul, S.; Chanprasertyothin, S.; Charernwat, P.; Panpunuan, P.; Sura, T.; et al. Genetic Polymorphism of Zinc Transporter-8 Gene (SLC30A8), Serum Zinc Concentrations, and Proteome Profiles Related to Type 2 Diabetes in Elderly. J. Clin. Med. 2025, 14, 790. https://doi.org/10.3390/jcm14030790

AMA Style

Sirivarasai J, Tristitworn P, Shantavasinkul PC, Roytrakul S, Chansirikarnjana S, Ruangritchankul S, Chanprasertyothin S, Charernwat P, Panpunuan P, Sura T, et al. Genetic Polymorphism of Zinc Transporter-8 Gene (SLC30A8), Serum Zinc Concentrations, and Proteome Profiles Related to Type 2 Diabetes in Elderly. Journal of Clinical Medicine. 2025; 14(3):790. https://doi.org/10.3390/jcm14030790

Chicago/Turabian Style

Sirivarasai, Jintana, Pimvaree Tristitworn, Prapimporn Chattranukulchai Shantavasinkul, Sittiruk Roytrakul, Sirintorn Chansirikarnjana, Sirasa Ruangritchankul, Suwannee Chanprasertyothin, Piangporn Charernwat, Pachara Panpunuan, Thanyachai Sura, and et al. 2025. "Genetic Polymorphism of Zinc Transporter-8 Gene (SLC30A8), Serum Zinc Concentrations, and Proteome Profiles Related to Type 2 Diabetes in Elderly" Journal of Clinical Medicine 14, no. 3: 790. https://doi.org/10.3390/jcm14030790

APA Style

Sirivarasai, J., Tristitworn, P., Shantavasinkul, P. C., Roytrakul, S., Chansirikarnjana, S., Ruangritchankul, S., Chanprasertyothin, S., Charernwat, P., Panpunuan, P., Sura, T., & Sritara, P. (2025). Genetic Polymorphism of Zinc Transporter-8 Gene (SLC30A8), Serum Zinc Concentrations, and Proteome Profiles Related to Type 2 Diabetes in Elderly. Journal of Clinical Medicine, 14(3), 790. https://doi.org/10.3390/jcm14030790

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