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J. Dev. Biol., Volume 5, Issue 2 (June 2017) – 3 articles

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Review
Sonic Hedgehog Signaling and Development of the Dentition
by Maisa Seppala, Gareth J. Fraser, Anahid A. Birjandi, Guilherme M. Xavier and Martyn T. Cobourne
J. Dev. Biol. 2017, 5(2), 6; https://doi.org/10.3390/jdb5020006 - 31 May 2017
Cited by 49 | Viewed by 9390
Abstract
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining [...] Read more.
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the established dentition. Shh also promotes the morphogenetic movement of epithelial cells in the early tooth bud, and influences cell cycle regulation, morphogenesis, and differentiation in the tooth germ. More recently, Shh has been identified as a stem cell regulator in the continuously erupting incisors of mice. Here, we review contemporary data relating to the role of Shh in odontogenesis, focusing on tooth development in mammals and cartilaginous fishes. We also describe the multiple actions of this signaling protein at the cellular level. Full article
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
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Editorial
Special Issue on HOX Genes in Development
by Vincenzo Zappavigna
J. Dev. Biol. 2017, 5(2), 5; https://doi.org/10.3390/jdb5020005 - 10 May 2017
Cited by 1 | Viewed by 4350
Abstract
This Special Issue of Journal of Developmental Biology (JDB) covers an indeed very “special” (at least to me) family of highly evolutionarily conserved genes, the Hox genes.[...] Full article
(This article belongs to the Special Issue Hox Genes and Development)
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Review
Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord?
by Cathy Danesin and Cathy Soula
J. Dev. Biol. 2017, 5(2), 4; https://doi.org/10.3390/jdb5020004 - 12 Apr 2017
Cited by 21 | Viewed by 8549
Abstract
A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity is the establishment of distinct neural [...] Read more.
A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity is the establishment of distinct neural progenitor cell domains during the process of pattern formation. The forming spinal cord, in particular, has served as an excellent model to unravel how progenitor cells respond to Shh to produce the appropriate pattern. In recent years, considerable advances have been made in our understanding of important parameters that control the temporal and spatial interpretation of the morphogen signal at the level of Shh-receiving progenitor cells. Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question of how moving the Shh source contributes to cell diversification in response to the morphogen. Here, we focus on the dynamics of Shh-producing cells and discuss specific roles for these time-variant Shh sources with regard to the temporal events occurring in the receiving field. Full article
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
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