The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection
Round 1
Reviewer 1 Report
The manuscript well described the multifactorial interconnection of immune activation and HIV-1 infection. It is well organized and provided an insightful review of various aspect of immune activation in HIV infected patients.
Author Response
We are grateful to the reviewer for the kind comment.
Reviewer 2 Report
Altogether this is a comprehensive and well-referenced review of the topic. The case of non-HIV associated immune activation that has been observed in chronic helminthic infection should have been added to the review in support of the role immune activation as such plays in CD4 depletion.
Borkow G, Bentwich Z. Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev 17:1012-30, 2004.
Author Response
We thank the reviewer for the comments and suggestions. A sentence on the topic has been added (see line 174) and the relative reference included.