Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers
, Akio Enta, Yoshiyuki Maruya, Sho Inomata, Hikaru Yamaguchi, Hayato Mine, Hironori Takagi, Yuki Ozaki, Masayuki Watanabe, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Kazuyuki Hamada and add
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Round 1
Reviewer 1 Report
This article provides an overview of the current understanding of the mechanisms of resistance to immune checkpoint inhibitors in NSCLC and other cancers. It highlights the important role of the Wnt/β-catenin pathway in tumor escape and immunomodulation, and identifies potential therapeutic strategies targeting this pathway. The authors' conclusions are supported by a comprehensive review of the relevant literature. This review is an important contribution to our understanding of the mechanisms of immune checkpoint inhibitor resistance in NSCLC and other cancers, and is a valuable resource for researchers and clinicians.
Reviewer 2 Report
Overall, this is a very well-written manuscript. The author showed a detailed introduction; the Wnt/β-catenin pathway is clearly depicted and easy to understand. The checkpoint inhibitor resistance with Wnt/β-catenin signaling is well presented and easy to follow. The conclusion part is also well presented. I don't see any concerns in this article.
Reviewer 3 Report
Title: Wnt/β-catenin Signaling and Resistance to Immune Check-point Inhibitors: From Non-Small Cell Lung Cancer to Other Cancers
ID: biomedicines-2146132
Article Type: Review
Journal: Biomedicines
Section: Immunology and Immunotherapy
The aim of the present review was to summarize findings on mechanisms of resistance to immune checkpoint inhibitors in Non-Small Cell Lung Cancer (NSCLC) and other cancers, focusing on Wnt/β-catenin signaling. In particular, the authors reviewed the molecular biology of Wnt/β-catenin signaling, and then discussed how it can induce immunoediting and resistance to immune checkpoint inhibitors. In addition, the authors described other mechanisms of immune checkpoint inhibitor resistance. Finally, they proposed therapeutic approaches to overcome these mechanisms.
The work is exhaustive and it is written very well, the concepts are clearly explained. For me there are no relevant changes to make.
