Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value

Round 1

Reviewer 1 Report

Introduction

Line 59-63: rewrite –correct the space between words…the sentence is to long. In general avoid using ;(semicolon) in the middle of sentence

Materials and methods

Did you also have information on the severity of the clinical presentation of COVID in these patients?

Was there a significant correlation between the severity of the COVID presentation and later occurrences of MIS-C

RESULTS

Line 186 – align text

DISCUSSION

Line 243 – 244: ..“ this is, 243 to our knowledge, the first report of the use of LUS as a predictor of outcome in patients 244 presenting with MIS-C. M“  - this is repeated many times

Line 259-260: „It would be therefore expected to find LUS pattern n 2 or 3 – B lines in different de- 259 grees of severity – in these patients who presented with acute heart failure in the context 260 of MIS-C“ ..sounds confusing

Line 262 lack of abbreviation for „Acute Respiratory Distress Syndrome“

Line 275-277: missing reference

Line 345-346: „Our results are in line 345 with literature under this aspect.“ – add those references

LIMITATIONS

In your study LUS was performed by three experienced intensivists so this is not a limitation of your study moreover it is a study strength

CONCLUSION

Sentences are also too long…you did not mention advantage of LUS use in comparison with lung X ray, especially in children

REFERENCE

equalize the font size of the references

„DOI numbers (Digital Object Identifier) are not mandatory but highly encouraged“ – put little more effort to add DOI 

need to add new reference: Skopljanac I, Ivelja MP, Barcot O, Brdar I, Dolic K, Polasek O, Radic M. Role of Lung Ultrasound in Predicting Clinical Severity and Fatality in COVID-19 Pneumonia. J Pers Med. 2021 Jul 30;11(8):757. doi: 10.3390/jpm11080757. 

Author Response

See the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

In 3. Results, 3.1.1. Demographic, please describe all comorbid conditions.

Comorbidities should be included in Table 2.

The discussion needs English editing.

Discussion Lines 339-341 need pediatric references (“More severe SARS-CoV-2 disease with increasing age”).

For a broader audience appeal reach, references 9, 10,11, and 12 are only commented on in lines 64 and 65, then on lines 346 -353, other references are cited (34, 44, 45); this discussion area needs to be rewritten and should comment at length references 9, 10, 11 and especially reference 12, Hameed S Radiology 2021; 298:e1-e10, a wider audience would appreciate if you demonstrate the comparison of other lung imaging techniques in your series of cases. 

Author Response

See attachment

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

I am satisfied with the corrections made.