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Article

Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children

by
Chiara Cirillo
1,†,
Emanuele Monda
1,†,
Raffaella Esposito
2,
Diego Colonna
3,
Cristina Falcone
1,
Federica Irrissuto
1,
Annapaola Cirillo
1,
Adelaide Fusco
1,
Federica Verrillo
1,
Gaetano Diana
1,
Marta Rubino
1,
Martina Caiazza
1,
Berardo Sarubbi
3,
Giuseppe Limongelli
1,*,‡ and
Maria Giovanna Russo
2,‡
1
Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, Italy
2
Paediatric Cardiology Unit, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, Italy
3
Adult Congenital Heart Diseases Unit, Monaldi Hospital, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work and share first authorship.
‡
These authors contributed equally to this work and share senior authorship.
J. Cardiovasc. Dev. Dis. 2024, 11(4), 129; https://doi.org/10.3390/jcdd11040129
Submission received: 11 March 2024 / Revised: 18 April 2024 / Accepted: 18 April 2024 / Published: 22 April 2024
Browse Figures
Versions Notes

Abstract

:
Introduction: Data on the prevalence and clinical significance of interventricular conduction disturbances (IVCDs) in children are scarce. While incomplete right bundle branch blocks (IRBBBs) seem to be the most frequent and benign findings, complete bundle blocks and fascicular blocks are often seen in children with congenital/acquired cardiac conditions. This study aims to delineate the prevalence and the diagnostic accuracy of IVCD in children admitted to a paediatric cardiology unit. Methods: Children admitted to the paediatric cardiology unit between January 2010 and December 2020 who had an ECG were included in the study. IVCDs were diagnosed according to standard criteria adjusted for age. Results: Three thousand nine hundred and ninety-three patients were enrolled. The median age was 3.1 years (IQR: 0.0–9.2 years), and 52.7% were males. IVCDs were present in 22.5% of the population: 17.4% of the population presented with IRBBBs, 4.8% with a complete right bundle branch block (CRBBB), 0.1% with a complete left bundle branch block (CLBBB), 0.2% with a left anterior fascicular block (LAFB) and 0.2% with a combination of CRBBB and LAFB. Also, 26% of children with congenital heart disease had an IVCD, and 18% of children with an IVCD had previous cardiac surgery. The overall sensitivity of IVCD in detecting a cardiac abnormality was 22.2%, with a specificity of 75.5%, a PPV of 83.1% and an NPV of 15.1%, but the values were higher for CLBBB and LAFB. Conclusions: IVCDs were present in one-fifth of children admitted to the cardiology unit. IRBBB was the most frequent disturbance, while CRBBB, CLBBB and fascicular blocks were much rarer, though they had a higher predictive value for cardiac abnormalities.

1. Introduction

Myocardial depolarization occurs in a sequential manner via the cardiac electrical conduction system. The impulse starts in the sinus node, expands to the AV node and then, via the bundle of His, reaches the left and right ventricular branches simultaneously (Figure 1). Intraventricular conduction delays (IVCDs) occur when there is an interruption in the transmission to the ventricles, generating bundle blocks, left bundle branch blocks (LBBBs) and right bundle branch block (RBBBs). The left branch is divided into two smaller branches, the left anterior and posterior branches, and a conduction disorder involving these branches is known as a fascicular block—a left anterior fascicular block (LAFB) or a left posterior fascicular block (LPFB) [1,2].
IVCDs are easily recognizable on surface electrocardiograms (ECGs), and their prevalence and correlation with cardiac disease has been thoroughly investigated in adult populations [3,4,5].
The prevalence and clinical significance of IVCDs in children is not completely understood. While incomplete right bundle branch blocks (IRBBBs) are commonly identified in paediatric ECGs and are considered benign findings, complete right bundle branch blocks (CRBBBs), complete left bundle branch blocks (CLBBBs) and fascicular blocks are much rarer and are often associated with congenital heart disease (CHD) and/or open-heart surgery [6,7].
This study aimed to delineate the prevalence of IVCDs and their clinical significance in a large cohort of children admitted to a paediatric cardiology unit in a large tertiary centre in Italy.

2. Methods

The study adhered to the principles of the Declaration of Helsinki and was approved by the local institutional ethics committee. Admissions to the Paediatric Cardiology Ward (Monaldi Hospital, Naples, Italy) between January 2010 and December 2020 were retrospectively screened.
All patients hospitalized in the paediatric cardiology ward and the paediatric cardiac intensive care unit (PICU) were included if they had an electrocardiogram (ECG) recorded on the first day of admission. Exclusion criteria were age over 18, unreadable ECG traces and paced rhythm.
Age at admission, gender, reason for admission, previous cardiac surgery and clinical examination findings were recorded.

2.1. Electrocardiography

A 12-lead ECG was recorded with the subjects in the supine position and was analyzed by two experienced cardiologists. IVCDs were diagnosed as follows.

2.2. Right Bundle Branch Block (RBBB)

RBBB was defined as the presence of rsR’ or sR’ in V1 with R’ greater than r or a R’ peak duration of 60 ms or more. When the QRS duration was >0.12 s, it was defined as complete RBBB (CRBBB); when the QRS duration was <0.12 s, it was defined as incomplete RBBB (IRBBB) [8,9].

2.3. Left Bundle Branch Block (LBBB)

Complete LBBB (CLBBB) was defined as the presence of a prolonged QRS >0.12 s or delayed intrinsic deflection in lead V6 (>75 ms), an absent Q wave, and slurred broad R waves in leads I, aVL and V6 [8,9].

2.4. Left Anterior Fascicular Block (LAFB)

LAFB was defined as the presence of left axis deviation, qR morphology in aVL, lead I and rS morphology in lead II, and aVF or rS in lead 2 with an S wave deeper in lead II than in lead III and a QRS duration < 0.12 s [8,9].

2.5. Left Posterior Fascicular Block (LPFB)

LPFB presents as an axis between 90° and 180° (not applicable at <16 years old due to the physiologically more rightward axis in children) and an rS pattern in leads I and aVL, a qR pattern in leads III and aVF, and a QRS duration less than 0.12 s [8,9].

2.6. Age Adjustments

In younger children and infants, the QRS duration was adjusted by age considering that a normal QRS duration is <0.09 s up to three years of age and <0.10 s for children up to adolescence and <0.12 s for 12 years and above [10,11].

2.7. Statistical Analysis

Data are presented as mean values and standard deviations if normally distributed and as medians with interquartile ranges (IQRs) if skewed. Categorical data are presented as counts divided by the total number of valid/available data. To assess the diagnostic value of each IVCD, a 2 × 2 table was constructed that included true- and false-positive and true- and false-negative test results. From the 2 × 2 frequency data, the sensitivity and specificity in detecting cardiac abnormalities were determined.
Diagnostic accuracy was defined as the total number of true-positive and true-negative tests/total number of patients. Positive predictive value (PPV), negative predictive value (NVP) and predictive accuracy were calculated and presented as absolute numbers and 95% confidence intervals.

3. Results

The clinical records of 4015 patients were screened. In total, 3 patients were 18 or older, 10 ECGs showed paced rhythm and 9 traces were not readable. The study enrolled a total of 3993 patients. The median age was 3.1 years (IQR: 0.0–9.2 y), and 52.7% were males.
The reasons for admission were CHD (59.33%), arrhythmia (17.8%), pericardial disease (1.63%), myocarditis (1.25%), channelopathies (1.18%), pulmonary hypertension (0.63%), cardiac tumour (0.38%), rheumatic heart disease (0.27%) and Kawasaki disease (0.27%). Only 15.52% of the admitted patients did not present any structural cardiac abnormalities at admission (Table 1, Figure 2). There were eight patients with dextrocardia, two of which cases were in the setting of situs inversus.
IVCDs were present in 22.54% of the population. In total, 17.38% of the population presented with IRBBB, 4.78% with CRBBB, 0.07% with CLBBB, 0.15% with LAFB and 0.15% with a combination of CRBBB and LAFB (Figure 3).
The distribution of IVCDs among different cardiac conditions was as follows: 68.4% were seen in children with CHD, 14.7% in children with arrhythmias and channelopathies, 14.4% in children with no morpho-functional cardiac abnormalities, 1.3% in those with cardiomyopathies/myocarditis and 1.3% in those with other rarer diseases (cardiac tumours, pulmonary hypertension and Kawasaki disease).

3.1. Association between IVCD and Cardiac Surgery

Of the 3993 children included in the study, 242 (6%) underwent open-heart surgery prior to the index admission. Eighteen percent of the children with IVCDs had previous cardiac surgery. The frequency of previous cardiac surgery was 10% in IRBBB, 41% in CRBBB, 83.5% in LAFB and 100% in both the LBBB and LAFB+ CRBBB groups. Table 2 summarizes the previous surgical procedures for each IVCD.

3.2. Association between Heart Diseases and IVCD Subtypes

Table 3 and Table 4 summarize the prevalence of each IVCD across different cardiac conditions.

3.3. CHD

Twenty-six percent of the children with CHD had an IVCD. The most frequent IVCD among the CHD patients was IRBBB (19% of all CHD patients), followed by CRBBB (6.24%); CLBBB, LAFB and CRBBB+ LAFB were much rarer (0.12%, 0.25% and 0.25%, respectively).
IRBBB was most frequently seen with ostium secundum atrial septal defect (ASD) (26.33%), pulmonary atresia with intact septum (24.2%), pulmonary atresia with ventricular septal defect (VSD) (22.7%), coarctation of the aorta (22.05%), pulmonary valve dysplasia (21%) and ostium primum ASD (18%).
CRBBB was most frequently seen with tetralogy of Fallot (26.1%), pulmonary atresia with VSD (18.2%) and tricuspid valve dysplasia (11.7%).
All six patients with CRBBB + LAFB had CHD, five of whom had an atrioventricular septal defect.
Three children in our cohort presented with CLBBB, and they all had CHD (truncus arteriosus, great vessel transposition and aortic stenosis).

3.4. Arrhythmias

Among patients presenting with a rhythm disturbance, 12.7% had an IVCD. The most frequent was IRBBB, seen in 12.7% of children, followed by CBBB, seen in 2.9% of children. IRBBB was also present in five (25%) children diagnosed with Brugada syndrome and four children with long QT syndrome.

3.5. Diagnostic Accuracy of Paediatric IVCD

The overall sensitivity of IVCD in detecting a cardiac abnormality was 22.2%, with a specificity of 75.48%, a PPV of 83.11%, an NPV of 15.13%, a positive likelihood ratio of 0.9, a negative likelihood ratio of 1.03, a prevalence of 84.47% and a 30.45% predictive accuracy (Figure 4).
IRBBB had a 19.1% mean sensitivity and an 85.1% specificity for CHD. With regard to CRBBB, the highest sensitivity was found for Ebstein anomaly (37.5%), followed by tetralogy of Fallot (26.1%).
CLBBB, LAFB and CRBBB + LAFB all had a specificity > 99.99% for CHD.
The sensitivity, specificity, PPV and NPV for each disease group and the sensitivity and specificity for individual diseases are reported in the Supplementary Materials (Tables S1–S5).

4. Discussion

This study describes the prevalence and clinical significance of IVCD in a paediatric population admitted to a paediatric cardiology unit. These data can be useful to understand the association of IVCD with paediatric cardiac conditions.

4.1. IRBBB and CRBBB

IVCDs are rare in children and were infrequent even in our selected population of children hospitalized for suspected/known cardiac conditions.
Overall, the most common IVCD in our cohort was IRBBB, followed by CRBBB.
Previous studies described a prevalence of IRBBB in 0.36% of children screened in a school program excluding those with CHD [12], in 3% of children with an ECG recorded in an outpatient setting [7] and in 1.2% of male highschoolers [13]. We showed a significantly higher prevalence (17.3%) compared to previous data, likely reflective of the hospitalized cohort with known or suspected heart disease.
Data on the clinical significance of IRBBBs in otherwise healthy children are scarce. IRBBB in a very young child can be considered a normal variant due to the persistence of right ventricular predominance; however, it is an unusual pattern for an older child [7].
IRBBBs can be observed in children with ASDs, and while previous data showed a lack of specificity, we reported a specificity of 85% and 82.5% for ostium secundum ASD and ostium primum ASD, respectively [14,15].
CRBBB is quite rare in children; it is reported to have a male preference and to become more frequent with age [16,17]. We reported a low prevalence of CRBBBs within our selected population, and we confirmed the known association with CHD before and especially after surgical repair. The right bundle branch is vulnerable to surgery in the proximal and distal regions, and IRBBBs and CRBBBs are described after repair of tetralogy of Fallot, atrioventricular septal defect and VSD [18,19,20].
Probst and colleagues reported a progressive cardiac conduction delay in families affected by Brugada syndrome with a SCN5A mutation. In our study, 25% of children with confirmed Brugada syndrome presented with IRBBBs and 5% with CRBBBs [21].

4.2. CLBBB and LAFB

Although CLBBB is seen in up to 2% of the adult population [22], it is very rare in children and mostly seen after open-heart surgery on the left side of the heart and rarely in cardiomyopathies or myocarditis. Our data confirm the rarity and the association in 100% of patients with previous cardiac surgery. Accuracy tests for CLBB and LAFB are reported but strongly limited by the small sample size.
LAFB and the association of LAFB + CRBBB, similarly to CLBBB, is also associated with structural heart disease, mostly with AV septal defects and coronary abnormalities, which was confirmed in our cohort [23].

5. Conclusions

To our knowledge, this is the first study reporting the prevalence and diagnostic accuracy of IVCD in admitted children with known/suspect cardiac conditions.
The main limitations of the study are the retrospective nature of the study and the selected population.
In conclusion, this study confirms the rarity of IVCD in children, even in those admitted for cardiac conditions, and that the presence of IVCD must warrant further investigations given its association with congenital, inherited or acquired cardiac conditions. CBBB and LAFB showed the strongest association with structural heart disease.

Supplementary Materials

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/jcdd11040129/s1, Table S1: Prevalence and diagnostic accuracy of Incomplete right bundle branch block in paediatric heart disease; Table S2: Prevalence and diagnostic accuracy of complete right bundle branch block in paediatric heart disease; Table S3: Prevalence and diagnostic accuracy of complete left bundle branch block in paediatric heart disease; Table S4: Prevalence and diagnostic accuracy of left anterior fascicular block in paediatric heart disease; Table S5: Prevalence and diagnostic accuracy of complete right bundle branch block + left anterior fascicular block in paediatric heart disease.

Author Contributions

Conceptualization, G.L., M.G.R. and B.S.; methodology, G.L., A.F. and C.C.; software, E.M., M.R. and D.C.; validation, E.M. and C.C.; formal analysis, E.M. and C.C.; investigation, G.L., E.M. and C.C.; resources, R.E., M.G.R. and B.S.; data curation C.F., F.I., A.C., F.V. and G.D.; writing—original draft preparation, C.C.; writing—review and editing, C.C., E.M. and G.L., visualization, C.C. and E.M.; supervision, G.L., M.G.R. and B.S.; project administration, M.C. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University Luigi Vanvitelli, AORN Dei Colli, Monaldi Hospital (protocol code: 318; 11 May 2017).

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

Data supporting the results of this article are available from the corresponding author upon reasonable request.

Conflicts of Interest

The authors declare no conflicts of interest.

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Jcdd 11 00129 g001
Figure 1. The Electrical System of the heart.
Figure 1. The Electrical System of the heart.
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Figure 2. Distribution of aetiologies in the overall cohort. Abbreviations: CHDs, congenital heart diseases; CMPs, cardiomyopathies; PH, pulmonary hypertension; RDH, rheumatic heart disease.
Figure 2. Distribution of aetiologies in the overall cohort. Abbreviations: CHDs, congenital heart diseases; CMPs, cardiomyopathies; PH, pulmonary hypertension; RDH, rheumatic heart disease.
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Figure 3. Prevalence of IVCDs in our cohort. Abbreviations: IVCD, intraventricular conduction disturbance; IV, intraventricular; IRBBB, incomplete right bundle branch block; CRBBB, complete right bundle branch block; CLBBB, complete left bundle branch block; LAFB, left anterior fascicular block; CHD, congenital heart disease.
Figure 3. Prevalence of IVCDs in our cohort. Abbreviations: IVCD, intraventricular conduction disturbance; IV, intraventricular; IRBBB, incomplete right bundle branch block; CRBBB, complete right bundle branch block; CLBBB, complete left bundle branch block; LAFB, left anterior fascicular block; CHD, congenital heart disease.
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Figure 4. Sensitivity and specificity of IVCD.
Figure 4. Sensitivity and specificity of IVCD.
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Table 1. Clinical characteristics of the study cohort. Data are presented as mean ± SD, median (IQR) or n (%).
Table 1. Clinical characteristics of the study cohort. Data are presented as mean ± SD, median (IQR) or n (%).
Clinical FeaturesOverall Cohort
(n = 3993)
Age, years3.1 (0.0–9.2)
Males2103 (52.7)
Congenital heart diseases2369 (59.33)
Patent foramen ovale109 (2.73)
Secundum atrial septal defect846 (21.19)
Primum atrial septal defect11 (0.27)
Atrioventricular septal defect77 (1.93)
Ventricular septal defect450 (11.27)
Patent ductus arteriosus523 (13.10)
Aortopulmonary window10 (0.25)
Abnormal origin of coronary artery from inappropriate situs14 (0.35)
Anomalous left coronary artery from the pulmonary artery2 (0.05)
Anomalies of the aortic arch61 (1.53)
Aberrant origin of the subclavian artery9 (0.22)
Partially anomalous pulmonary venous connection2 (0.05)
Totally anomalous pulmonary venous connection19 (0.48)
Tricuspid valve atresia22 (0.55)
Tricuspid valve dysplasia17 (0.43)
Ebstein anomaly8 (0.20)
Tricuspid stenosis1 (0.02)
Pulmonary stenosis183 (4.58)
Pulmonary valve dysplasia38 (0.95)
Pulmonary atresia and intact ventricular septum33 (0.83)
Pulmonary atresia and ventricular septal defect22 (0.55)
Tetralogy of Fallot157 (3.93)
Truncus arteriosus8 (0.20)
Mitral valve abnormalities52 (1.30)
Bicuspid aortic valve33 (0.83)
Aortic valve stenosis52 (1.30)
Aortic subvalvular stenosis4 (0.10)
Coarctation of the aorta127 (3.18)
Hypoplastic left heart syndrome17 (0.43)
Transposition of the great arteries64 (1.60)
Congenitally corrected transposition of the great arteries6 (0.15)
Double outlet right ventricle44 (1.10)
Double inlet left ventricle11 (0.27)
Cor triatriatum3 (0.07)
Abnormalities of atrial situs16 (0.40)
Cardiomyopathies65 (1.63)
Hypertrophic cardiomyopathy34 (0.85)
Dilated cardiomyopathy28 (0.70)
Restrictive cardiomyopathy1 (0.02)
Left ventricular non compaction2 (0.05)
Rheumatic heart disease11 (0.27)
Myocarditis50 (1.25)
Pericardial disease71 (1.78)
Acute pericarditis67 (1.68)
Chronic pericarditis4 (0.10)
Kawasaki disease8 (0.20)
Pulmonary hypertension25 (0.63)
Cardiac tumours15 (0.38)
Rhabdomyomas15 (0.38)
Disorder of the cardiac rhythm712 (17.83)
Frequent supraventricular premature complexes48 (1.20)
Frequent ventricular premature complexes78 (1.95)
Ventricular pre-excitation130 (3.26)
Atrial ectopic tachycardia130 (3.26)
Atrioventricular re-entry tachycardia237 (5.93)
Atrioventricular node re-entry tachycardia134 (3.36)
Atrial flutter15 (0.38)
Atrial fibrillation4 (0.10)
Ventricular tachycardia7 (0.17)
Cardiac channelopathies47 (1.18)
Long QT syndrome27 (0.68)
Brugada syndrome20 (0.50)
No morpho-functional abnormalities620 (15.52)
Cardiac surgery prior to admission242 (0.6)
Table 2. Cardiac repairs associated with intraventricular delay subtypes.
Table 2. Cardiac repairs associated with intraventricular delay subtypes.
TOF CoA VSD ASD AVSDPDAShone ComplexPA + VSDArterial SwitchGlenn/FontanDORV Truncus Tot
IRBBB131613650431041075
CRBBB365852206224072
CLBBB1000000010024
LAFB0000300110005
CRBBB + LAFB 5 1 6
Abbreviations: TOF, tetralogy of Fallot; CoA, aortic coarctation; ASD, atrial septal defect; VSD, ventricular septal defect; AVSD, atrioventricular septal defect; PDA, patent ductus arteriosus; PA, pulmonary atresia, DORV, double outlet right ventricle; IRBBB, incomplete right bundle branch block; CRBBB, complete right bundle branch block; LAFB, left anterior fascicular block; CLBBB, complete left bundle branch block.
Table 3. Clinical characteristics of the overall cohort according to the type of intraventricular conduction delay. Data are presented as mean ± SD, median (IQR) or n (%).
Table 3. Clinical characteristics of the overall cohort according to the type of intraventricular conduction delay. Data are presented as mean ± SD, median (IQR) or n (%).
IRBBB
(n = 694)		Isolated CRBBB
(n = 191)		CLBBB
(n = 3)		Isolated LAFB
(n = 6)		CRBBB + LAFB
(n = 6)
Age, years6.0 (1–11)7.5 (4–12)10 (8.5–17)3.5 (0.2–9.7)2.5 (0–11)
Males393 (56.6)123 (64.4)1 (33.3)1 (16.7)3 (50)
Previous Cardiac Surgery75 (10.8)72 (37.7)3 (100)5 (83.5%)6 (100)
Congenital heart diseases453 (65.3)148 (77.5)3 (100)5 (83.3)6 (100)
Patent foramen ovale9 (1.30)5 (2.62)0 (0)0 (0)0 (0)
Secundum atrial septal defect223 (32.13)43 (22.51)0 (0)1 (16.7)0 (0)
Primum atrial septal defect2 (0.29)0 (0)0 (0)0 (0)0 (0)
Atrioventricular septal defect8 (1.15)7 (3.66)0 (0)2 (33.3)5 (83.3)
Ventricular septal defect58 (8.36)28 (14.66)0 (0)1 (16.7)0 (0)
Patent ductus arteriosus82 (11.82)10 (5.24)0 (0)1 (16.7)0 (0)
Aortopulmonary window2 (0.29)1 (0.52)0 (0)0 (0)0 (0)
Abnormal origin of coronary artery from inappropriate situs3 (0.43)1 (0.52)0 (0)0 (0)0 (0)
Anomalous left coronary artery from the pulmonary artery0 (0)0 (0)0 (0)0 (0)0 (0)
Anomalies of the aortic arch11 (1.58)3 (1.57)0 (0)0 (0)0 (0)
Aberrant origin of the subclavian artery2 (0.29)0 (0)0 (0)0 (0)0 (0)
Partially anomalous pulmonary venous connection0 (0)1 (0.52)0 (0)0 (0)0 (0)
Totally anomalous pulmonary venous connection3 (0.43)2 (1.05)0 (0)0 (0)0 (0)
Tricuspid valve atresia1 (0.14)0 (0)0 (0)1 (16.7)0 (0)
Tricuspid valve dysplasia1 (0.14)2 (1.05)0 (0)0 (0)0 (0)
Ebstein anomaly1 (0.14)3 (1.57)0 (0)0 (0)0 (0)
Tricuspid stenosis0 (0)1 (0.52)0 (0)0 (0)0 (0)
Pulmonary stenosis34 (4.90)9 (4.71)0 (0)0 (0)0 (0)
Pulmonary valve dysplasia8 (1.15)0 (0)0 (0)0 (0)0 (0)
Pulmonary atresia and intact ventricular septum8 (1.15)0 (0)0 (0)0 (0)0 (0)
Pulmonary atresia and ventricular septal defect5 (0.72)4 (2.09)0 (0)0 (0)0 (0)
Tetralogy of Fallot11 (1.58)41 (21.47)0 (0)1 (16.7)0 (0)
Truncus arteriosus0 (0)0 (0)1 (33.3)0 (0)0 (0)
Mitral valve abnormalities10 (1.44)4 (2.09)0 (0)0 (0)0 (0)
Bicuspid aortic valve4 (0.58)2 (1.05)0 (0)0 (0)0 (0)
Aortic valve stenosis7 (1.01)1 (0.52)1 (33.3)0 (0)0 (0)
Aortic subvalvular stenosis1 (0.14)0 (0)0 (0)0 (0)0 (0)
Coarctation of the aorta28 (4.03)15 (7.85)0 (0)0 (0)0 (10)
Hypoplastic left heart syndrome2 (2.29)1 (0.52)0 (0)0 (0)0 (0)
Transposition of the great arteries10 (1.44)6 (3.14)1 (33.3)1 (16.7)0 (0)
Congenitally corrected transposition of the great arteries0 (0)0 (0)0 (0)0 (0)0 (0)
Double outlet right ventricle4 (0.58)7 (3.66)0 (0)0 (0)1 (16.7)
Double inlet left ventricle1 (0.14)1 (0.52)0 (0)0 (0)0 (0)
Cor triatriatum0 (0)0 (0)0 (0)0 (0)0 (0)
Abnormalities of atrial situs0 (0)1 (0.52)0 (0)0 (0)0 (0)
Cardiomyopathies3 (0.14)0 (0)0 (0)0 (0)0 (0)
Hypertrophic cardiomyopathy2 (0.29)0 (0)0 (0)0 (0)0 (0)
Dilated cardiomyopathy1 (0.14)0 (0)0 (0)0 (0)0 (0)
Restrictive cardiomyopathy0 (0)0 (0)0 (0)0 (0)0 (0)
Left ventricular non compaction0 (0)0 (0)0 (0)0 (0)0 (0)
Rheumatic heart disease1 (0.14)0 (0)0 (0)0 (0)0 (0)
Myocarditis8 (1.15)0 (0)0 (0)0 (0)0 (0)
Pericardial disease14 (2.02)1 (0.52)0 (0)0 (0)0 (0)
Acute pericarditis13 (1.87)1 (0.52)0 (0)0 (0)0 (0)
Chronic pericarditis1 (0.14)0 (0)0 (0)0 (0)0 (0)
Kawasaki disease1 (0.14)0 (0)0 (0)0 (0)0 (0)
Pulmonary hypertension3 (0.43)1 (0.52)0 (0)0 (0)0 (0)
Cardiac tumours1 (0.14)0 (0)0 (0)0 (0)0 (0)
Rhabdomyomas1 (0.14)0 (0)0 (0)0 (0)0 (0)
Disorder of the cardiac rhythm91 (13.11)21 (10.99)0 (0)1 (16.7)0 (0)
Frequent supraventricular premature complexes4 (0.58)0 (0)0 (0)0 (0)0 (0)
Frequent ventricular premature complexes10 (1.44)2 (1.05)0 (0)0 (0)0 (0)
Ventricular pre-excitation13 (1.87)2 (1.05)0 (0)1 (16.7)0 (0)
Atrial ectopic tachycardia13 (1.87)10 (5.24)0 (0)0 (0)0 (0)
Atrioventricular re-entry tachycardia29 (4.18)6 (3.14)0 (0)0 (0)0 (0)
Atrioventricular node re-entry tachycardia26 (3.75)6 (3.14)0 (0)0 (0)0 (0)
Atrial flutter1 (0.14)0 (0)0 (0)0 (0)0 (0)
Atrial fibrillation0 (0)0 (0)0 (0)0 (0)0 (0)
Ventricular tachycardia2 (2.9)0 (0)0 (0)0 (0)0 (0)
Cardiac channelopathies9 (1.30)1 (0.52)0 (0)0 (0)0 (0)
Long QT syndrome4 (0.58)0 (0)0 (0)0 (0)0 (0)
Brugada syndrome5 (0.72)1 (0.52)0 (0)0 (0)0 (0)
No morpho-functional abnormalities110 (15.85)19 (9.95)0 (0)0 (0)0 (0)
Abbreviations: CLBBB, complete left bundle branch block; CRBBB, complete right bundle branch block; IRBBB, incomplete right bundle branch block; LAFB, left anterior fascicular block.
Table 4. Association between heart diseases and intraventricular conduction delay. Data are presented as mean ± SD, median (IQR), or n (%).
Table 4. Association between heart diseases and intraventricular conduction delay. Data are presented as mean ± SD, median (IQR), or n (%).
IRBBB
(n = 694)		Isolated CRBBB
(n = 191)		CLBBB
(n = 3)		Isolated LAFB
(n = 6)		CRBBB + LAFB
(n = 6)		No Abnormalities
Congenital heart diseases (n = 2369)453 (19.12)148 (6.25)3 (0.13)5 (0.21)6 (0.25)1754 (74.04)
Patent foramen ovale (n = 109)9 (8.26)5 (4.59)0 (0)0 (0)0 (0)95 (87.15)
Secundum atrial septal defect (n = 846)223 (26.33)43 (5.08)0 (0)1 (0.12)0 (0)579 (68.36)
Primum atrial septal defect (n = 11)2 (18.18)0 (0)0 (0)0 (0)0 (0)9 (81.82)
Atrioventricular septal defect (n = 77)8 (10.39)7 (9.09)0 (0)2 (2.60)5 (6.49)55 (71.43)
Ventricular septal defect (n = 450)58 (12.80)28 (6.18)0 (0)1 (0.22)0 (0)363 (80.13)
Patent ductus arteriosus (n = 523)82 (15.35)10 (1.87)0 (0)10 (0)430 (80.52)
Aortopulmonary window (n = 10)2 (20)1 (10)0 (0)0 (0)0 (0)7 (70)
Abnormal origin of coronary artery from inappropriate situs (n = 14)3 (21.43)1 (7.14)0 (0)0 (0)0 (0)10 (71.43)
Anomalous left coronary artery from the pulmonary artery (n = 2)0 (0)0 (0)0 (0)0 (0)0 (0)2 (100)
Anomalies of the aortic arch (n = 61)11 (18.03)3 (4.92)0 (0)0 (0)0 (0)47 (77.05)
Aberrant origin of the subclavian artery
(n = 9)		2 (22.22)0 (0)0 (0)0 (0)0 (0)7 (77.77)
Partially anomalous pulmonary venous connection (n = 2)0 (0)1 (50)0 (0)0 (0)0 (0)1 (50)
Totally anomalous pulmonary venous connection (n = 19)3 (15.79)2 (10.53)0 (0)0 (0)0 (0)14 (73.68)
Tricuspid valve atresia (n = 22)1 (4.54)0 (0)0 (0)1 (4.54)0 (0)20 (90.91)
Tricuspid valve dysplasia (n = 17)1 (5.88)2 (11.76)0 (0)0 (0)0 (0)14 (82.35)
Ebstein anomaly (n = 8)1 (12.5)3 (37.5)0 (0)0 (0)0 (0)4 (50)
Tricuspid stenosis (n = 1)0 (0)1 (100)0 (0)0 (0)0 (0)0 (0)
Pulmonary stenosis (n = 183)34 (18.58)9 (4.92)0 (0)0 (0)0 (0)140 (76.5)
Pulmonary valve dysplasia (n = 38)8 (21.05)0 (0)0 (0)0 (0)0 (0)30 (78.95)
Pulmonary atresia and intact ventricular septum (n = 33)8 (24.24)0 (0)0 (0)0 (0)0 (0)25 (75.75)
Pulmonary atresia and ventricular septal defect (n = 22)5 (22.73)4 (18.18)0 (0)0 (0)0 (0)13 (59.09)
Tetralogy of Fallot (n = 157)11 (7)41 (26.11)0 (0)1 (0.64)0 (0)104 (66.24)
Truncus arteriosus (n = 8)0 (0)0 (0)1 (12.5)0 (0)0 (0)7 (87.5)
Mitral valve abnormalities (n = 52)10 (18.87)4 (7.55)0 (0)0 (0)0 (0)38 (71.7)
Bicuspid aortic valve (n = 33)4 (12.12)2 (6.06)0 (0)0 (0)0 (0)27 (81.81)
Aortic valve stenosis (n = 52)7 (13.46)1 (1.92)1 (1.92)0 (0)0 (0)43 (82.7)
Aortic subvalvular stenosis (n = 4)1 (25)0 (0)0 (0)0 (0)0 (0)3 (75)
Coarctation of the aorta (n = 127)28 (22.05)15 (11.81)0 (0)0 (0)0 (0)83 (65.35)
Hypoplastic left heart syndrome (n = 17)2 (11.76)1 (5.88)0 (0)0 (0)0 (0)14 (82.35)
Transposition of the great arteries (n = 64)10 (15.62)6 (9.37)1 (1.56)1 (1.56)0 (0)46 (71.87)
Congenitally corrected transposition of the great arteries (n = 6)0 (0)0 (0)0 (0)0 (0)0 (0)6 (100)
Double outlet right ventricle (n = 44)4 (9.09)7 (15.9)0 (0)0 (0)1 (2.27)32 (72.72)
Double inlet left ventricle (n = 11)1 (9.09)1 (9.09)0 (0)0 (0)0 (0)9 (100)
Cor triatriatum (n = 3)0 (0)0 (0)0 (0)0 (0)0 (0)3 (100)
Abnormalities of atrial situs (n = 16)0 (0)1 (6.25)0 (0)0 (0)0 (0)14 (87.5)
Cardiomyopathies (n = 65)3 (4.61)0 (0)0 (0)0 (0)0 (0)62 (95.38)
Hypertrophic cardiomyopathy (n = 34)2 (5.88)0 (0)0(0)0 (0)0 (0)32 (94.11)
Dilated cardiomyopathy (n = 28)1 (3.57)0 (0)0 (0)0 (0)0 (0)27 (96.43)
Restrictive cardiomyopathy (n = 1)0 (0)0 (0)0 (0)0 (0)0 (0)1 (100)
Left ventricular non compaction (n = 2)0 (0)0 (0)0 (0)0 (0)0 (0)2 (100)
Rheumatic heart disease (n = 11)1 (9.09)0 (0)0 (0)0 (0)0 (0)10 (90.9)
Myocarditis (n = 50)8 (16)0 (0)0 (0)0 (0)0 (0)42 (84)
Pericardial disease (n = 71)14 (19.71)1 (1.41)0 (0)0 (0)0 (0)56 (78.87)
Acute pericarditis (n = 67)13 (19.4)1 (1.49)0(0)0 (0)0 (0)53 (79.1)
Chronic pericarditis (n = 4)1 (25)0 (0)0 (0)0 (0)0 (0)3 (75)
Kawasaki disease (n = 8)1 (12.5)0 (0)0 (0)0 (0)0 (0)7 (87.5)
Pulmonary hypertension (n = 25)3 (12)1 (4)0 (0)0 (0)0 (0)21 (84)
Cardiac tumours (n = 15)1 (6.67)0 (0)0 (0)0 (0)0 (0)14 (93.33)
Rhabdomyomas (n = 15)1 (6.77)0 (0)0 (0)0 (0)0 (0)14 (93.33)
cardiac rhythm disorders (n = 712)91 (12.78)21 (2.95)0 (0)1 (0.14)0 (0)599 (84.13)
Frequent supraventricular premature complexes (n = 48)4 (8.33)0 (0)0 (0)0 (0)0 (0)44 (91.67)
Frequent ventricular premature complexes (n = 78)10 (12.82)2 (2.56)0 (0)0 (0)0 (0)66 (84.61)
Ventricular pre-excitation (n = 130)13 (10)2 (1.53)0 (0)1 (0.8)0 (0)114 (87.69)
Atrial ectopic tachycardia (n = 130)13 (10)10 (7.69)0 (0)0 (0)0 (0)107 (82.3)
Atrioventricular re-entry tachycardia (n = 237)29 (12.24)6 (2.53)0 (0)0 (0)0 (0)202 (85.23)
Atrioventricular node re-entry tachycardia (n = 134)26 (19.4)6 (4.48)0 (0)0 (0)0 (0)102 (76.12)
Atrial flutter (n = 15)1 (6.67)0 (0)0 (0)0 (0)0 (0)14 (93.33)
Atrial fibrillation (n = 4)0 (0)0 (0)0 (0)0 (0)0 (0)4 (100)
Ventricular tachycardia (n = 7)2 (28.57)0 (0)0 (0)0 (0)0 (0)5 (71.43)
Cardiac channelopathies (n = 47)9 (19.15)1 (2.1)0 (0)0 (0)0 (0)37 (78.72)
Long QT syndrome (n = 27)4 (14.81)0 (0)0 (0)0 (0)0 (0)23 (85.18)
Brugada syndrome (n = 20)5 (25)1 (5)0 (0)0 (0)0 (0)14 (70)
No morpho-functional abnormalities (n = 620)127 (20.48)25 (4)0 (0)0 (0)0 (0)599 (96.61)
Abbreviations: CLBBB, complete left bundle branch block; CRBBB, complete right bundle branch block; IRBBB, incomplete right bundle branch block; LAFB, left anterior fascicular block.
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Cirillo, C.; Monda, E.; Esposito, R.; Colonna, D.; Falcone, C.; Irrissuto, F.; Cirillo, A.; Fusco, A.; Verrillo, F.; Diana, G.; et al. Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children. J. Cardiovasc. Dev. Dis. 2024, 11, 129. https://doi.org/10.3390/jcdd11040129

AMA Style

Cirillo C, Monda E, Esposito R, Colonna D, Falcone C, Irrissuto F, Cirillo A, Fusco A, Verrillo F, Diana G, et al. Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children. Journal of Cardiovascular Development and Disease. 2024; 11(4):129. https://doi.org/10.3390/jcdd11040129

Chicago/Turabian Style

Cirillo, Chiara, Emanuele Monda, Raffaella Esposito, Diego Colonna, Cristina Falcone, Federica Irrissuto, Annapaola Cirillo, Adelaide Fusco, Federica Verrillo, Gaetano Diana, and et al. 2024. "Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children" Journal of Cardiovascular Development and Disease 11, no. 4: 129. https://doi.org/10.3390/jcdd11040129

APA Style

Cirillo, C., Monda, E., Esposito, R., Colonna, D., Falcone, C., Irrissuto, F., Cirillo, A., Fusco, A., Verrillo, F., Diana, G., Rubino, M., Caiazza, M., Sarubbi, B., Limongelli, G., & Russo, M. G. (2024). Prevalence and Clinical Significance of Intraventricular Conduction Disturbances in Hospitalized Children. Journal of Cardiovascular Development and Disease, 11(4), 129. https://doi.org/10.3390/jcdd11040129

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