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Volume 11
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10.22543/2392-7674.1550
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

Challenges of Anticoagulant Treatment in Atrial Fibrillation with Liver Disease

by
Alina Doina Nicoara
1,2,
Andra Iulia Suceveanu
1,3,*,
Ionut Eduard Iordache
1,4,
Iulia Tania Andronache
5,
Andreea Nelson Twakor
2,
Andreea Georgiana Sunda
2,
Ioan Cristian Nichita
1,
Anca Pantea Stoian
6,
Felix Voinea
1,7 and
Adrian Paul Suceveanu
1,3
1
Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania
2
Department of Internal Medicine, St. Ap. Andrei Emergency County Hospital, Constanta, Romania
3
Department of Gastroenterology, St. Ap. Andrei Emergency County Hospital, 900470 Constanta, Romania
4
Department of General Surgery, St. Ap. Andrei Emergency County Hospital, Constanta, Romania
5
Department of Rheumatology, Dr. Alexandru Gafencu Military Emergency Hospital Constanta, Constanta, Romania
6
Department of Diabetes, Nutrition and Metabolic Disorders, Carol Davila University of Medicine and Farmacy, Bucharest, Romania
7
Department of Urology, St. Ap. Andrei Emergency County Hospital, Constanta, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2024, 11(2), 363-373; https://doi.org/10.22543/2392-7674.1550
Submission received: 8 May 2024 / Revised: 8 June 2024 / Accepted: 3 August 2024 / Published: 31 October 2024

Abstract

Managing anticoagulation therapy in individuals with atrial fibrillation who also have liver disease is highly challenging due to altered blood clotting processes and the risk of bleeding due to liver dysfunction. The literature highlights the complex nature of anticoagulant therapy in these patients, emphasizing the need for personalized treatment methods that take into account both thrombosis and bleeding risks. Research has shown a higher occurrence of atrial fibrillation in people with cirrhosis, highlighting the need to find the best anticoagulation methods based on the severity of liver disease and patient-specific factors. The debate over the safety and effectiveness of direct oral anticoagulants compared to traditional drugs like warfarin in cirrhotic patients with atrial fibrillation is still ongoing. Collaborative initiatives between experts in hepatology and cardiology are needed to address the complicated interplay between liver disease and atrial fibrillation, promoting interdisciplinary care models that enhance patient safety and treatment effectiveness. By prioritizing a patient-centered approach guided by extensive research, future directions in the hemostatic management of cirrhotic patients with atrial fibrillation may improve clinical decision-making and therapeutic outcomes.
Keywords: liver disease; atrial fibrillation; vitamin K antagonist; direct-acting oral anticoagulants liver disease; atrial fibrillation; vitamin K antagonist; direct-acting oral anticoagulants

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MDPI and ACS Style

Nicoara, A.D.; Suceveanu, A.I.; Iordache, I.E.; Andronache, I.T.; Nelson Twakor, A.; Sunda, A.G.; Nichita, I.C.; Pantea Stoian, A.; Voinea, F.; Suceveanu, A.P. Challenges of Anticoagulant Treatment in Atrial Fibrillation with Liver Disease. J. Mind Med. Sci. 2024, 11, 363-373. https://doi.org/10.22543/2392-7674.1550

AMA Style

Nicoara AD, Suceveanu AI, Iordache IE, Andronache IT, Nelson Twakor A, Sunda AG, Nichita IC, Pantea Stoian A, Voinea F, Suceveanu AP. Challenges of Anticoagulant Treatment in Atrial Fibrillation with Liver Disease. Journal of Mind and Medical Sciences. 2024; 11(2):363-373. https://doi.org/10.22543/2392-7674.1550

Chicago/Turabian Style

Nicoara, Alina Doina, Andra Iulia Suceveanu, Ionut Eduard Iordache, Iulia Tania Andronache, Andreea Nelson Twakor, Andreea Georgiana Sunda, Ioan Cristian Nichita, Anca Pantea Stoian, Felix Voinea, and Adrian Paul Suceveanu. 2024. "Challenges of Anticoagulant Treatment in Atrial Fibrillation with Liver Disease" Journal of Mind and Medical Sciences 11, no. 2: 363-373. https://doi.org/10.22543/2392-7674.1550

APA Style

Nicoara, A. D., Suceveanu, A. I., Iordache, I. E., Andronache, I. T., Nelson Twakor, A., Sunda, A. G., Nichita, I. C., Pantea Stoian, A., Voinea, F., & Suceveanu, A. P. (2024). Challenges of Anticoagulant Treatment in Atrial Fibrillation with Liver Disease. Journal of Mind and Medical Sciences, 11(2), 363-373. https://doi.org/10.22543/2392-7674.1550

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