Next Article in Journal
Evaluation of Short-Term Complications in Laparoscopic Peritoneal Dialysis Catheter Placement—A Single Tertiary Center Experience
Previous Article in Journal
Challenges in Diagnosing Nasopharyngeal Tumors
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JMMS
Volume 11
Issue 2
10.22543/2392-7674.1544
jmms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Biological Effect of Modern Bioactive Materials Used in Direct and Indirect Capping; In Vitro Study

by
Irina Maria Gheorghiu
1,†,
Alexandru Andrei Iliescu
2,*,
George Alexandru Denis Popescu
3,
Stana Paunica
4,† and
Anca Silvia Dumitriu
4
1
Department of Restorative Odontotherapy, Carol Davila University of Medicine, Faculty of Stomatology, Bucharest, Romania
2
Department of Oral Rehabilitation, Craiova University of Dental Medicine, Craiova, Romania
3
Doctoral School, Carol Davila University of Medicine, Bucharest, Romania
4
Department of Periodontology, Faculty of Stomatology, Carol Davila University of Medicine, Bucharest, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Mind Med. Sci. 2024, 11(2), 444-451; https://doi.org/10.22543/2392-7674.1544
Submission received: 12 March 2024 / Revised: 12 April 2024 / Accepted: 5 July 2024 / Published: 31 October 2024

Abstract

Objective. In this study, the biological effect of MTA Repair HP (Mineral Trioxide Aggregate Repair High Plasticity) and Biodentine have been tested on a stabilized fibroblast cell line NCTC clone 929. Materials and Methods. We assessed quantitative and qualitative parameters related to cytotoxic effect of the investigated products. The experimental period was 96 hours. Statistical analysis was performed with Kruskal-Wallis and Wilcoxon tests. Results. The detached cells test showed no statistically significant difference on cell culture for Biodentine and MTA Repair HP, while for the cellular density assay we found the same biological effect on the tested fibroblasts in the first 24 and 48 h, but a significant different cellular response for the investigated pulp capping materials for the next 48 h of the experiment. Conclusions. The results demonstrated that the materials presented a very low level of cytotoxicity. Biodentine showed in all parameters better biological effects than MTA Repair HP, expressed by lower and limited cellular damage and a higher cell density.
Keywords: pulp; capping materials; fibroblasts; cell culture; cytotoxicity; restorative dentistry; bioactive products pulp; capping materials; fibroblasts; cell culture; cytotoxicity; restorative dentistry; bioactive products

Share and Cite

MDPI and ACS Style

Gheorghiu, I.M.; Iliescu, A.A.; Popescu, G.A.D.; Paunica, S.; Dumitriu, A.S. Biological Effect of Modern Bioactive Materials Used in Direct and Indirect Capping; In Vitro Study. J. Mind Med. Sci. 2024, 11, 444-451. https://doi.org/10.22543/2392-7674.1544

AMA Style

Gheorghiu IM, Iliescu AA, Popescu GAD, Paunica S, Dumitriu AS. Biological Effect of Modern Bioactive Materials Used in Direct and Indirect Capping; In Vitro Study. Journal of Mind and Medical Sciences. 2024; 11(2):444-451. https://doi.org/10.22543/2392-7674.1544

Chicago/Turabian Style

Gheorghiu, Irina Maria, Alexandru Andrei Iliescu, George Alexandru Denis Popescu, Stana Paunica, and Anca Silvia Dumitriu. 2024. "Biological Effect of Modern Bioactive Materials Used in Direct and Indirect Capping; In Vitro Study" Journal of Mind and Medical Sciences 11, no. 2: 444-451. https://doi.org/10.22543/2392-7674.1544

APA Style

Gheorghiu, I. M., Iliescu, A. A., Popescu, G. A. D., Paunica, S., & Dumitriu, A. S. (2024). Biological Effect of Modern Bioactive Materials Used in Direct and Indirect Capping; In Vitro Study. Journal of Mind and Medical Sciences, 11(2), 444-451. https://doi.org/10.22543/2392-7674.1544

Article Metrics

Back to TopTop