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Volume 11
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10.22543/2392-7674.1540
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Article

Assessment of the Bioaccumulation of Nicotine and Cotinine by the Crustacean Daphnia magna

by
Ana Maria Vlasceanu
1,
Daniela Luiza Baconi
1,*,
Octavian Tudorel Olaru
1,
Daniela Grădinaru
1 and
Viorela Gabriela Nitescu
2
1
Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
2
Grigore Alexandrescu Emergency Clinical Hospital for Children, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2024, 11(2), 459-465; https://doi.org/10.22543/2392-7674.1540
Submission received: 5 May 2024 / Revised: 5 June 2024 / Accepted: 2 July 2024 / Published: 31 October 2024

Abstract

Objectives. This study aimed to investigate the toxicity of nicotine and its metabolite cotinine on crustacean D. magna, and evaluate the quantity of compounds accumulated by D. magna. Materials and Methods. The bioassays involved the exposure of D. magna to varying doses of nicotine and cotinine, for 24 h and 48 h. The amount of bioaccumulated nicotine and cotinine was determined by an HPLC-DAD method. Results. The study has revealed that nicotine is more toxic than cotinine on D. magna, as the medium lethal concentration (LC50) values were higher for nicotine compared to cotinine. After 24 h of exposure, D. magna accumulated comparable amounts of nicotine and cotinine. However, after 48 h of exposure, the crustacean accumulated significantly lower levels of nicotine, which is consistent with the higher toxicity of nicotine compared to cotinine. Conclusions. These findings demonstrated that nicotine triggers various alterations in aquatic organism, hence jeopardizing the equilibrium of the aquatic ecosystem within a little timeframe.
Keywords: nicotine; cotinine; Daphnia magna; bioaccumulation nicotine; cotinine; Daphnia magna; bioaccumulation

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MDPI and ACS Style

Vlasceanu, A.M.; Baconi, D.L.; Olaru, O.T.; Grădinaru, D.; Nitescu, V.G. Assessment of the Bioaccumulation of Nicotine and Cotinine by the Crustacean Daphnia magna. J. Mind Med. Sci. 2024, 11, 459-465. https://doi.org/10.22543/2392-7674.1540

AMA Style

Vlasceanu AM, Baconi DL, Olaru OT, Grădinaru D, Nitescu VG. Assessment of the Bioaccumulation of Nicotine and Cotinine by the Crustacean Daphnia magna. Journal of Mind and Medical Sciences. 2024; 11(2):459-465. https://doi.org/10.22543/2392-7674.1540

Chicago/Turabian Style

Vlasceanu, Ana Maria, Daniela Luiza Baconi, Octavian Tudorel Olaru, Daniela Grădinaru, and Viorela Gabriela Nitescu. 2024. "Assessment of the Bioaccumulation of Nicotine and Cotinine by the Crustacean Daphnia magna" Journal of Mind and Medical Sciences 11, no. 2: 459-465. https://doi.org/10.22543/2392-7674.1540

APA Style

Vlasceanu, A. M., Baconi, D. L., Olaru, O. T., Grădinaru, D., & Nitescu, V. G. (2024). Assessment of the Bioaccumulation of Nicotine and Cotinine by the Crustacean Daphnia magna. Journal of Mind and Medical Sciences, 11(2), 459-465. https://doi.org/10.22543/2392-7674.1540

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