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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

The Postfinasteride Syndrome; An Overview

by
David L. Rowland
1,
Ion G. Motofei
2,*,
Florian Popa
2,
Vlad D. Constantin
2,
Adriana Vasilache
3,
Ioana Păunică
4,
Cristian Bălălău
2,
Georgeta P. Păunică
2,
Petrisor Banu
2 and
Stana Păunică
3
1
Department of Psychology, Valparaiso University, Valparaiso, IN 46383, USA
2
Department of Surgery and Urology, Carol Davila University, 050474 Bucharest, Romania
3
Department of Periodontology, Carol Davila University, 050474 Bucharest, Romania
4
Faculty of General Medicine, Carol Davila University, 050474 Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2016, 3(2), 99-107; https://doi.org/10.22543/2392-7674.1051
Submission received: 31 July 2016 / Revised: 31 August 2016 / Accepted: 20 September 2016 / Published: 24 September 2016

Abstract

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.” Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse effects after treatment cessation. Moreover, we argue that finasteride adverse effects occurring during finasteride administration should be delineated from postfinasteride side effects (encountered after treatment cessation), suggesting the need to be addressed separately within a therapeutic perspective. Until a tailored therapeutic approach of postfinasteride syndrome becomes available, we have noted that hand preference and sexual orientation seem to be useful as possible predicting factors for finasteride side effects and postfinasteride syndrome. Finally, even though finasteride administration is considered relatively safe, literature data urges prudence. Specifically, recent studies report that some subjects receiving finasteride develop severe depressive episodes including suicidal thoughts, in part due to persistent sexual side effects.
Keywords: finasteride; adverse effects; post-finasteride syndrome; mental disorders; sexual dysfunctions finasteride; adverse effects; post-finasteride syndrome; mental disorders; sexual dysfunctions

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MDPI and ACS Style

Rowland, D.L.; Motofei, I.G.; Popa, F.; Constantin, V.D.; Vasilache, A.; Păunică, I.; Bălălău, C.; Păunică, G.P.; Banu, P.; Păunică, S. The Postfinasteride Syndrome; An Overview. J. Mind Med. Sci. 2016, 3, 99-107. https://doi.org/10.22543/2392-7674.1051

AMA Style

Rowland DL, Motofei IG, Popa F, Constantin VD, Vasilache A, Păunică I, Bălălău C, Păunică GP, Banu P, Păunică S. The Postfinasteride Syndrome; An Overview. Journal of Mind and Medical Sciences. 2016; 3(2):99-107. https://doi.org/10.22543/2392-7674.1051

Chicago/Turabian Style

Rowland, David L., Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, and Stana Păunică. 2016. "The Postfinasteride Syndrome; An Overview" Journal of Mind and Medical Sciences 3, no. 2: 99-107. https://doi.org/10.22543/2392-7674.1051

APA Style

Rowland, D. L., Motofei, I. G., Popa, F., Constantin, V. D., Vasilache, A., Păunică, I., Bălălău, C., Păunică, G. P., Banu, P., & Păunică, S. (2016). The Postfinasteride Syndrome; An Overview. Journal of Mind and Medical Sciences, 3(2), 99-107. https://doi.org/10.22543/2392-7674.1051

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