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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

The Substrate of the Biopsychosocial Influences in the Carcinogenesis of the Digestive Tract

by
Georgică C. Târtea
1,2,*,
Cristina Florescu
1,2,
Daniel Pirici
1,3,
Daniel Caragea
1,4,
Elena A. Târtea
1,5 and
Cristin C. Vere
1,6
1
University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Cardiology, Romania
3
Department of Pathology, Romania
4
Department of Nephrology, Romania
5
Department of Neurology, Romania
6
Department of Gastroenterology and Hepatology, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2016, 3(2), 108-117; https://doi.org/10.22543/2392-7674.1043
Submission received: 31 July 2016 / Revised: 31 August 2016 / Accepted: 20 September 2016 / Published: 24 September 2016

Abstract

Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis. Both the evolution and the pathogenesis of digestive neoplasms remain incompletely elucidated. As a multifactorial disease, it can be approached by taking into account the biopsychosocial influences via enteric nervous system. Many peptides and non-peptides having a neurotransmitter role can be found in the enteric nervous system, which can influence the neoplastic process directly or indirectly by affecting some angiogenic, growth, and metastasis factors. However, neurotransmitters can also cause directly, through intercellular signalizing, the angiogenesis, the proliferation, and the digestive neoplasms’ metastasis. This new approach to neoplasms of the digestive tube assumes broader psychosocial factors can play an important role in the understanding the ethiopathogenie, the evolution of the disease, and determination of possible molecular targeted therapies; it also suggests that behavioral strategies may be important for maintaining a healthy state with respect to the digestive tract.
Keywords: enteric nervous system; neurotransmitters; carcinogenesis; biopsychosocial influences enteric nervous system; neurotransmitters; carcinogenesis; biopsychosocial influences

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MDPI and ACS Style

Târtea, G.C.; Florescu, C.; Pirici, D.; Caragea, D.; Târtea, E.A.; Vere, C.C. The Substrate of the Biopsychosocial Influences in the Carcinogenesis of the Digestive Tract. J. Mind Med. Sci. 2016, 3, 108-117. https://doi.org/10.22543/2392-7674.1043

AMA Style

Târtea GC, Florescu C, Pirici D, Caragea D, Târtea EA, Vere CC. The Substrate of the Biopsychosocial Influences in the Carcinogenesis of the Digestive Tract. Journal of Mind and Medical Sciences. 2016; 3(2):108-117. https://doi.org/10.22543/2392-7674.1043

Chicago/Turabian Style

Târtea, Georgică C., Cristina Florescu, Daniel Pirici, Daniel Caragea, Elena A. Târtea, and Cristin C. Vere. 2016. "The Substrate of the Biopsychosocial Influences in the Carcinogenesis of the Digestive Tract" Journal of Mind and Medical Sciences 3, no. 2: 108-117. https://doi.org/10.22543/2392-7674.1043

APA Style

Târtea, G. C., Florescu, C., Pirici, D., Caragea, D., Târtea, E. A., & Vere, C. C. (2016). The Substrate of the Biopsychosocial Influences in the Carcinogenesis of the Digestive Tract. Journal of Mind and Medical Sciences, 3(2), 108-117. https://doi.org/10.22543/2392-7674.1043

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