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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

Insights Into the Pathogenesis of Nicotine Addiction. Could a Salivary Biosensor Be Useful in Nicotine Replacement Therapy (NRT)?

by
Anida-Maria Băbțan
1,
Nausica B. Petrescu
1,
Anca Ionel
1,
Bianca A. Boșca
2,*,
Willi A. Uriciuc
1,
Claudia N. Feurdean
1,
Codruța I. Mirică
1,
Roxana Bordea
1,
Viorel Miclăuș
3,
Flavia Ruxanda
3,
Adina D. Todea
4,
Teodora G. Alexescu
5,
Radu S. Câmpian
1,† and
Aranka Ilea
1,†
1
Oral Health and Dental Office Management, Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Haţieganu University of Medicine and Pharmacy, Pasteur Street, No 5, 400012 Cluj-Napoca, Romania
2
Department of Histology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Pasteur Street, No 5, 400012 Cluj-Napoca, Romania
3
Department of Cell Biology, Histology, Embryology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Pasteur Street, No 5, 400012 Cluj-Napoca, Romania
4
Department of Pneumophtisiology, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Pasteur Street, No 5, 400012 Cluj-Napoca, Romania
5
Department of Internal Medicine, Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Pasteur Street, No 5, 400012 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Mind Med. Sci. 2019, 6(2), 196-209; https://doi.org/10.22543/7674.62.P196209
Submission received: 11 April 2019 / Revised: 27 July 2019 / Accepted: 27 July 2019 / Published: 9 October 2019

Highlights

  • Smoking addiction has strong pharmacological, psycho-social, and media support.
  • The development of a double-effect salivary biosensor could represent a useful approach in nicotine addiction therapy.

Abstract

Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large number of smoking-related pathologies. The present review offers insights into nicotine addiction physiopathology, as well as social and medical implications, with emphasis on its correlation with Advanced Glycation End Products (AGEs). Therapeutic strategies and new approaches to nicotine assessment and cessation treatment are discussed, noting that such strategies could take into account the possibility of slow and gradual nicotine release from a device attached to a prosthetic piece, based on salivary nicotine-concentration feedback. This approach could offer real-time and home-based self-therapy monitoring by the physician and the patient for follow-up and improve long-term cessation treatment success- Graphical abstract.
Keywords: pathogenesis; nicotine addiction; salivary biosensor; Nicotine Replacement Therapy; NRT pathogenesis; nicotine addiction; salivary biosensor; Nicotine Replacement Therapy; NRT

Share and Cite

MDPI and ACS Style

Băbțan, A.-M.; Petrescu, N.B.; Ionel, A.; Boșca, B.A.; Uriciuc, W.A.; Feurdean, C.N.; Mirică, C.I.; Bordea, R.; Miclăuș, V.; Ruxanda, F.; et al. Insights Into the Pathogenesis of Nicotine Addiction. Could a Salivary Biosensor Be Useful in Nicotine Replacement Therapy (NRT)? J. Mind Med. Sci. 2019, 6, 196-209. https://doi.org/10.22543/7674.62.P196209

AMA Style

Băbțan A-M, Petrescu NB, Ionel A, Boșca BA, Uriciuc WA, Feurdean CN, Mirică CI, Bordea R, Miclăuș V, Ruxanda F, et al. Insights Into the Pathogenesis of Nicotine Addiction. Could a Salivary Biosensor Be Useful in Nicotine Replacement Therapy (NRT)? Journal of Mind and Medical Sciences. 2019; 6(2):196-209. https://doi.org/10.22543/7674.62.P196209

Chicago/Turabian Style

Băbțan, Anida-Maria, Nausica B. Petrescu, Anca Ionel, Bianca A. Boșca, Willi A. Uriciuc, Claudia N. Feurdean, Codruța I. Mirică, Roxana Bordea, Viorel Miclăuș, Flavia Ruxanda, and et al. 2019. "Insights Into the Pathogenesis of Nicotine Addiction. Could a Salivary Biosensor Be Useful in Nicotine Replacement Therapy (NRT)?" Journal of Mind and Medical Sciences 6, no. 2: 196-209. https://doi.org/10.22543/7674.62.P196209

APA Style

Băbțan, A.-M., Petrescu, N. B., Ionel, A., Boșca, B. A., Uriciuc, W. A., Feurdean, C. N., Mirică, C. I., Bordea, R., Miclăuș, V., Ruxanda, F., Todea, A. D., Alexescu, T. G., Câmpian, R. S., & Ilea, A. (2019). Insights Into the Pathogenesis of Nicotine Addiction. Could a Salivary Biosensor Be Useful in Nicotine Replacement Therapy (NRT)? Journal of Mind and Medical Sciences, 6(2), 196-209. https://doi.org/10.22543/7674.62.P196209

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