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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

Nanoparticles in the Treatment of Chronic Lung Diseases

by
Teodora G. Alexescu
1,*,
Simina Tarmure
1,
Vasile Negrean
1,
Maria Cosnarovici
2,
Victoria M. Ruta
3,
Ionela Popovici
1,
Ioana Para
1,
Mirela G. Perne
1,
Olga H. Orasan
1 and
Doina A. Todea
3
1
4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania
2
Institute of Oncology Prof. Dr. Ion Chiricuta, Cluj Napoca, Romania
3
Department of Pneumology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj- Napoca, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2019, 6(2), 224-231; https://doi.org/10.22543/7674.62.P224231
Submission received: 14 June 2019 / Revised: 21 August 2019 / Accepted: 21 August 2019 / Published: 9 October 2019

Highlights

  • In chronic lung diseases, nano-carrier systems provide the advantage of sustained drug release in lung tissue, resulting in reduced dosing frequency and improved patient compliance.
  • Further studies are required in order to better understand the potential long-term risk of excipient toxicity and nanoscale carriers.

Abstract

Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents. Nanoparticles can be defined as complex drug carrier systems which incorporate and protect a certain drug or particle. Nanoparticles can be administered via different routes, such as intravenous injection, oral administration, or pulmonary inhalation. Even though the use of nano-carriers via pulmonary inhalation is heavily debated, this system represents an attractive alternative to the intravenous or oral routes, due to the unique anatomical and physiological features of the lungs and the minimal interactions between the targeted site and other organs. Some of the widely used nano-carriers for the treatment of chronic pulmonary diseases, via pulmonary route, are as follows: polymeric nanoparticles, liposomal nano-carriers, solid lipid nanoparticles, and submicron emulsions. Nano-carrier systems provide the advantage of sustained-drug release in the lung tissue resulting in reduced dosing frequency and improved patient compliance. Further studies focusing on understanding the mechanisms of action of nanoparticles and improving their chemical structure are required in order to better understand the potential long-term risk of excipient toxicity and nanoscale carriers.
Keywords: nanoparticles; chronic lung diseases; therapy; sustained drug release; patient compliance nanoparticles; chronic lung diseases; therapy; sustained drug release; patient compliance

Share and Cite

MDPI and ACS Style

Alexescu, T.G.; Tarmure, S.; Negrean, V.; Cosnarovici, M.; Ruta, V.M.; Popovici, I.; Para, I.; Perne, M.G.; Orasan, O.H.; Todea, D.A. Nanoparticles in the Treatment of Chronic Lung Diseases. J. Mind Med. Sci. 2019, 6, 224-231. https://doi.org/10.22543/7674.62.P224231

AMA Style

Alexescu TG, Tarmure S, Negrean V, Cosnarovici M, Ruta VM, Popovici I, Para I, Perne MG, Orasan OH, Todea DA. Nanoparticles in the Treatment of Chronic Lung Diseases. Journal of Mind and Medical Sciences. 2019; 6(2):224-231. https://doi.org/10.22543/7674.62.P224231

Chicago/Turabian Style

Alexescu, Teodora G., Simina Tarmure, Vasile Negrean, Maria Cosnarovici, Victoria M. Ruta, Ionela Popovici, Ioana Para, Mirela G. Perne, Olga H. Orasan, and Doina A. Todea. 2019. "Nanoparticles in the Treatment of Chronic Lung Diseases" Journal of Mind and Medical Sciences 6, no. 2: 224-231. https://doi.org/10.22543/7674.62.P224231

APA Style

Alexescu, T. G., Tarmure, S., Negrean, V., Cosnarovici, M., Ruta, V. M., Popovici, I., Para, I., Perne, M. G., Orasan, O. H., & Todea, D. A. (2019). Nanoparticles in the Treatment of Chronic Lung Diseases. Journal of Mind and Medical Sciences, 6(2), 224-231. https://doi.org/10.22543/7674.62.P224231

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