Insecticide Resistance Development and the Underlying Mechanisms

A special issue of Agronomy (ISSN 2073-4395). This special issue belongs to the section "Pest and Disease Management".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 2365

Special Issue Editors


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Guest Editor
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Interests: insecticide resistance evolution; Cytochrome P450; gene regulation; rice plant hoppers; pest management
Special Issues, Collections and Topics in MDPI journals
Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Science, Beijing 100193, China
Interests: insecticide resistance; Cytochrome P450; insect; whitefly; gene regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The evolution of insecticide resistance represents a global constraint to agricultural production. Understanding the molecular basis of insecticide resistance and designing efficient insecticide resistance management strategies (IRM) are of paramount importance. It is recognized that insect resistance to insecticides is developed principally through two mechanisms, either the target insensitivity mechanism caused by gene mutations or the metabolic resistance mechanism through changes in the quantity and quality of detoxification enzyme genes. The metabolic resistance mechanism is responsible for the development of cross-resistance to a wide range of insecticides. In addition, multiple resistance mechanisms are commonly observed in resistant insects; however, their relative contribution to the phenotype remains elusive and their interactive effects on insecticide resistance development are under studied. Moreover, the impact of ecological factors, such as climate warming, plant viruses or insect bacterial symbiosis, on insecticide resistance evolution is less understood. Here, we are gathering both original research and review papers on the following research topics:

  • Resistance development and basic nature of insecticide resistance;
  • Candidate genes and genome alterations associated with the phenotype identified by high-throughput comparative transcriptomic, proteomic and/or genomic approaches;
  • Mutations in coding gene(s) or cis and/or trans mutations involved in resistance;
  • Functional validation of the candidate genes or mutations by in vitro and in vivo methods;
  • Interactive effects of two or multiple mechanisms on insecticide resistance development;
  • Fitness cost of insecticide resistance and suggestions on resistance management strategies;
  • The impact of ecological factors, such as climate warming, plant viruses or insect bacterial symbiosis, on insecticide resistance development;
  • Design of molecular diagnostics to monitor insecticide resistance in the field;
  • Products or methods of pest management and resistance management.

Dr. Youhui Gong
Dr. Xin Yang
Guest Editor

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Keywords

  • insecticide resistance development and evolution
  • resistance mechanism
  • target insensitivity mechanism
  • metabolic resistance mechanism
  • detoxification enzyme genes
  • overexpression
  • gene mutation
  • phenotype
  • resistance contribution
  • ecological factors

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Published Papers (1 paper)

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Research

19 pages, 1603 KiB  
Article
Multiple Insecticide Resistance and Associated Metabolic-Based Mechanisms in a Myzus Persicae (Sulzer) Population
by Jinfeng Hu, Feng Chen, Jun Wang, Wenhua Rao, Lei Lin and Guocheng Fan
Agronomy 2023, 13(9), 2276; https://doi.org/10.3390/agronomy13092276 - 29 Aug 2023
Cited by 4 | Viewed by 2009
Abstract
The green peach aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae), is an economically devastating crop pest worldwide. The M. persicae (SEF-R) population of a cabbage field in China was tested for susceptibilities to 13 insecticides. Compared with the susceptible population (FFJ-S), extremely high and [...] Read more.
The green peach aphid, Myzus persicae (Sulzer) (Hemiptera: Aphididae), is an economically devastating crop pest worldwide. The M. persicae (SEF-R) population of a cabbage field in China was tested for susceptibilities to 13 insecticides. Compared with the susceptible population (FFJ-S), extremely high and high resistance to beta-cypermethrin (324-fold) and imidacloprid (106.9-fold) was detected in SEF-R. More importantly, this is the first report of resistance in the field M. persicae population to sulfoxaflor (32.4-fold), flupyradifurone (9.5-fold), pymetrozine (34.8-fold), spirotetramat (8.1-fold), flonicamid (5.8-fold), and broflanilide (15.8-fold) in China when compared with FFJ-S. The resistance factor decayed to a low level to sulfoxaflor and pymetrozine after 15 generations without any selection pressure. The resistance-related mutations (R81T and kdr) detected in SEF indicated target-site resistance to neonicotinoids and pyrethroids, respectively. Biochemical assays revealed the involvement of monooxygenase, carboxylesterase, superoxide dismutase, and peroxidase in a multi-insecticide resistance mechanism. The overexpression of P450s, esterases, and a UDP-glycosyltransferase might be responsible for the multi-insecticide resistance in SEF-R. The knockdown of CYP6CY3 in SEF-R increased its susceptibility to imidacloprid, thiacloprid, and thiamethoxam, which verified that P450s play vital roles in neonicotinoid metabolism. Our findings provide guidance for the rational use of insecticides to delay resistance development in GPA. Full article
(This article belongs to the Special Issue Insecticide Resistance Development and the Underlying Mechanisms)
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