Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 1336

Special Issue Editors


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Guest Editor
Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Hamburg, Germany
Interests: arthroplasty; revision arthroplasty; periprosthetic joint infection
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Adana City Training and Research Hospital, Department of Orthopedic and Traumatology, Adana, Turkey
Interests: arthroplasty; revision arthroplasty; periprosthetic joint infection

Special Issue Information

Dear Colleagues,

We are thrilled to announce our Special Issue focusing on "Prevention, Diagnostic and Antimicrobial Treatment of Periprosthetic Joint Infection—Proven Meets Innovative, Complementary Approaches". Periprosthetic joint infection (PJI) remains a significant challenge in orthopedic surgery, necessitating comprehensive strategies for prevention, reliable diagnostic methods and effective antimicrobial treatments. Our aim in this collection is to bring together current research findings on proven and novel approaches to the prevention, diagnosis and treatment of PJIs and to combine them with expert knowledge on various aspects of PJI management.

This Special Issue serves as an essential resource for orthopedic surgeons, infectious disease specialists, microbiologists, and healthcare professionals committed to addressing the complexities of periprosthetic joint infections and enhancing patient care.

Prof. Dr. Mustafa Citak
Dr. Jochen Salber
Dr. Osman Çiloğlu
Guest Editors

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Keywords

  • periprosthetic joint infection
  • antimicrobial treatments
  • orthopedics
  • joint arthroplasty

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Published Papers (1 paper)

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Review

10 pages, 256 KiB  
Review
The Role of Rifampin in Prosthetic Joint Infections: Efficacy, Challenges, and Clinical Evidence
by Jakrapun Pupaibool
Antibiotics 2024, 13(12), 1223; https://doi.org/10.3390/antibiotics13121223 - 17 Dec 2024
Viewed by 1011
Abstract
Rifampin is a crucial antibiotic in the management of prosthetic joint infections (PJI), particularly due to its effectiveness against staphylococcal bacteria and its ability to penetrate and disrupt biofilms. This review evaluates rifampin’s role by examining its mechanism of action, clinical efficacy, and [...] Read more.
Rifampin is a crucial antibiotic in the management of prosthetic joint infections (PJI), particularly due to its effectiveness against staphylococcal bacteria and its ability to penetrate and disrupt biofilms. This review evaluates rifampin’s role by examining its mechanism of action, clinical efficacy, and integration into treatment regimens based on recent evidence and guidelines. Rifampin’s synergistic effects with other antibiotics, such as β-lactams and vancomycin, enhance bacterial eradication, and some evidence shows that it improves patient outcomes. However, evidence supporting its use is limited by the scarcity of robust human clinical trials, and challenges such as potential drug interactions and resistance development necessitate careful management. Ongoing research is needed to refine its use and address existing limitations in clinical practice. Full article
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