Mechanisms of Antimicrobial Peptides on Pathogens, 2nd Edition
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2280
Special Issue Editor
Interests: antimicrobial peptides; peptide synthesis; peptide drug formulation;combination antibiotic therapy; bacterial biofilm; microbial resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antimicrobial peptides (AMPs) are considered to be a promising alternative for conventional antimicrobials. They are widely distributed in nature as developmental components of the innate immunity of living organisms. The majority of AMPs are cationic, amphipathic molecules that exhibit a strong activity against a broad spectrum of pathogens, including multi-drug resistant strains. Their ability to eliminate and prevent biofilm structures has been proven in in vitro and in vivo studies.
The most common mode of action of AMPs is the disruption of cell membranes, which leads to microbial lysis. Due to their unique mechanisms of action based on interactions with the microbial cell membrane, AMPs can act on slow-growing or even non-growing bacteria and are active against biofilms. This mode also has a lower risk of acquired resistance or cross-resistance with other agents compared to other modes of action, which makes it an attractive template for the design of new antimicrobials for specific applications. Several mechanisms of membrane perturbation are discussed on a molecular level (e.g., toroidal pore formation, the carpet model, void formation, clustering of lipids, and membrane curvature). However, as of now, numerous AMPs with non-conventional modes of action have also been described. The determination and understanding of the modes of action of AMPs are crucial for the rational design of improved antimicrobial compounds.
The aim of this Special Issue is to extend the scientific knowledge of AMPs in order to examine their modes of action, understand possible mechanisms of microbial resistance, explore potential clinical applications, and present the latest achievements in this field of research.
Dr. Malgorzata Paduszynska
Guest Editor
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Keywords
- Antimicrobial peptides
- mechanisms of antimicrobial activities
- interactions with bacterial membrane
- microbial resistance
- inhibition of biofilm formation
- biofilm eradication
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