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Antibiotics
Special Issues
The Appropriateness of Antibiotic Prescribing in Hospitals and Ambulatory Care
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The Appropriateness of Antibiotic Prescribing in Hospitals and Ambulatory Care

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 571

Special Issue Editors

Dr. Francesco Ferrara

E-Mail Website
Guest Editor
Pharmaceutical Department, Asl Napoli 3 Sud, Dell’amicizia Street 72, 80035 Nola, Italy
Interests: pharmacology; antimicrobic resistance; governance; appropriateness; infectivology
Special Issues, Collections and Topics in MDPI journals
Dr. Roberto Langella

E-Mail Website
Guest Editor
Italian Society of Hospital Pharmacy (SIFO), SIFO Secretariat of the Lombardy Region, Via Carlo Farini 81, 20159 Milan, Italy
Interests: clinical pharmacy; antimicrobic resistance; governance; appropriateness; pharmacoeconomy
Dr. Andrea Zovi

E-Mail Website
Guest Editor
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, 62032 Camerino, Italy
Interests: pharmaceutical; food; governance; appropriateness; nutrition

Special Issue Information

Dear Colleagues,

We thought of this Special Issue entitled “The Appropriateness of Antibiotic Prescribing in Hospitals and Ambulatory Care” because we strongly believe that in the next few years the proper use of antimicrobial drugs will be crucial not only for a proper pharmaceutical governance but also to limit the phenomenon of antimicrobial resistance (AMR). Based on the increasing incidence of bacterial resistance, also towards newer anti-infectives, the World Health Organization (WHO) estimated that by 2050 we will face an increase in deaths due to AMR with no viable therapeutic alternatives left. National antimicrobial resistance programs seem to be limiting the AMR phenomenon but are failing to stop the huge consumption of anti-infective drugs, consumption that is often inappropriate and the cause of resistance. The risk of having superbugs is enormous, and in this Special Issue, we want to gather all scientific contributions that aim to highlight proper clinical practice, to raise everyone’s awareness toward extreme therapeutic appropriateness, and to make sure that we increasingly encourage a proactive cooperation between physicians, pharmacists, and all healthcare professionals for the good of the world population.

Dr. Francesco Ferrara
Dr. Roberto Langella
Dr. Andrea Zovi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacology
  • antimicrobic resistance
  • governance
  • appropriateness
  • infectivology

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Published Papers (1 paper)

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Review

14 pages, 894 KiB  
Review
Optimizing Antibiotic Use: Addressing Resistance Through Effective Strategies and Health Policies
by Maurizio Capuozzo, Andrea Zovi, Roberto Langella, Alessandro Ottaiano, Marco Cascella, Manlio Scognamiglio and Francesco Ferrara
Antibiotics 2024, 13(12), 1112; https://doi.org/10.3390/antibiotics13121112 - 21 Nov 2024
Viewed by 400
Abstract
Background: Antimicrobial resistance (AMR) has emerged as a significant challenge to public health, posing a considerable threat to effective disease management on a global scale. The increasing incidence of infections caused by resistant bacteria has led to heightened morbidity and mortality rates, particularly [...] Read more.
Background: Antimicrobial resistance (AMR) has emerged as a significant challenge to public health, posing a considerable threat to effective disease management on a global scale. The increasing incidence of infections caused by resistant bacteria has led to heightened morbidity and mortality rates, particularly among vulnerable populations. Main text: This review analyzes current strategies and health policies adopted in the European Union (EU) and Italy to manage AMR, presenting an in-depth examination of approaches for containment and mitigation. Factors such as excessive prescriptions, self-medication, and the misuse of antibiotics in livestock contribute to the selection and spread of resistant strains. Furthermore, this review provides a detailed overview of resistance mechanisms, including enzymatic inactivation, reduced permeability, efflux pump activity, and target site protection, with specific examples provided. The review underscores the urgent need to develop new antibiotics and implement diagnostic testing to ensure targeted prescriptions and effectively combat resistant infections. Current estimates indicate that AMR-related infections cause over 60,000 deaths annually in Europe and the United States, with projections suggesting a potential rise to 10 million deaths per year by 2050 if current trends are not reversed. The review also examines existing public health policies in Europe and Italy, focusing on national and regional strategies to combat AMR. These include promoting responsible antibiotic use, improving surveillance systems, and encouraging research and development of new therapeutic options. Conclusions: Finally, the review presents short- and long-term perspectives from the authors, suggesting actionable steps for policymakers and healthcare providers. Ultimately, a coordinated and multidisciplinary approach involving healthcare professionals, policymakers, and the public is essential to mitigate the impact of AMR and ensure the effectiveness of antibiotics for future generations. Full article
(This article belongs to the Special Issue The Appropriateness of Antibiotic Prescribing in Hospitals and Ambulatory Care)
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