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Antibiotics
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Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant,...
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Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant, and Treatment, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 January 2025 | Viewed by 2393

Special Issue Editors

Dr. Anusak Kerdsin

E-Mail Website
Guest Editor
Faculty of Public Health, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon, Thailand
Interests: Streptococcus suis; antimicrobial-resistant bacteria; bacterial zoonosis
Special Issues, Collections and Topics in MDPI journals
Dr. Jinquan Li

E-Mail Website
Guest Editor
Key Laboratory of Environment Correlative Dietology, Interdisciplinary Sciences Institute, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China
Interests: phage; lysin; antimicrobial-resistant bacteria
Special Issues, Collections and Topics in MDPI journals
Dr. Jonathan Frye

E-Mail Website
Guest Editor
Poultry Microbiological Safety and Processing Research Unit, USDA ARS Russell Research Center (RRC), Athens, GA, USA
Interests: antimicrobial resistance; Salmonella; plasmids; genomics; zoonotic
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The overuse and inappropriate use of antibiotics in medicine, agriculture, fishery, and food animal production is an under-appreciated problem. This problem is considered to have potential public health implications. The agricultural, food animal, and aquatic environments have been regarded as vital reservoirs and sources of antibiotic residues, antibiotic-resistant bacteria, and resistance genes. Antibiotic residues have been reported to have a negative impact on public health and food safety with regard to drug toxicity, immunopathological diseases, carcinogenicity, allergic reactions, etc., whereas antibiotic resistant bacteria lead to treatment failure in humans and animals, increasing the number of infections worldwide, and spreading throughout the globe.

The first edition of the Special Issue “Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant, and Treatment” (https://www.mdpi.com/journal/antibiotics/special_issues/insights_antibiotics) was published in 2023.

It is a successful collection with 15 excellent papers and has encouraged us to open a second edition covering the same topic. As a continuation of the first Special Issue, this Special Issue focuses on antibiotic-resistant bacteria including antimicrobial-resistant genes, genetic or genomic insights, epidemiology, and their characteristics, from medicine, agriculture, fishery, and food animal products. It includes applications and consequences of antibiotics, related bioactive agents, or natural compounds to treat bacterial infection/contamination in medicine, agriculture, fishery, and food animal production, as well as new methods for assaying antibiotic-resistant bacteria or antibiotic residues in medicine, agriculture, or the environment. Qualitative and quantitative studies exploring the determinants of antimicrobial use in agriculture, fishery, and food animal production are also accepted. In addition, original research, reviews, perspectives, or commentary opinions are welcome.

Dr. Anusak Kerdsin
Dr. Jinquan Li
Dr. Jonathan Frye
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics
  • antibiotic residues
  • antibiotic-resistant bacteria
  • medicine
  • agriculture
  • fishery
  • food animal

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Related Special Issue

Published Papers (2 papers)

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Research

11 pages, 2448 KiB  
Article
Validation of Recombinase Polymerase Amplification with In-House Lateral Flow Assay for mcr-1 Gene Detection of Colistin Resistant Escherichia coli Isolates
by Naeem Ullah, Nutchaba Suchanta, Umaporn Pimpitak, Pitak Santanirand, Nutthee Am-In and Nuntaree Chaichanawongsaroj
Antibiotics 2024, 13(10), 984; https://doi.org/10.3390/antibiotics13100984 - 17 Oct 2024
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Abstract
Background/Objectives: The emergence of the mobilized colistin resistance 1 (mcr-1) gene, which causes colistin resistance, is a serious concern in animal husbandry, particularly in pigs. Although antibiotic regulations in many countries have prohibited the use of colistin in livestock, the persistence [...] Read more.
Background/Objectives: The emergence of the mobilized colistin resistance 1 (mcr-1) gene, which causes colistin resistance, is a serious concern in animal husbandry, particularly in pigs. Although antibiotic regulations in many countries have prohibited the use of colistin in livestock, the persistence and dissemination of this plasmid-mediated gene require effective and rapid monitoring. Therefore, a rapid, sensitive, and specific method combining recombinase polymerase amplification (RPA) with an in-house lateral flow assay (LFA) for the mcr-1 gene detection was developed. Methods: The colistin agar test and broth microdilution were employed to screen 152 E. coli isolates from pig fecal samples of five antibiotic-used farms. The established RPA-in-house LFA was validated with PCR for mcr-1 gene detection. Results: The RPA-in-house LFA was completed within 35 min (20 min of amplification and 5–15 min on LFA detection) at 37 °C. The sensitivity, specificity, and accuracy were entirely 100% in concordance with PCR results. No cross-reactivity was detected with seven common pathogenic bacteria or other mcr gene variants. Conclusions: Therefore, the in-house RPA-LFA serves as a point-of-care testing tool that is rapid, simple, and portable, facilitating effective surveillance of colistin resistance in both veterinary and clinical settings, thereby enhancing health outcomes. Full article
(This article belongs to the Special Issue Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant, and Treatment, 2nd Edition)
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15 pages, 2082 KiB  
Article
Phenotypic and Genotypic Profiles of Extended-Spectrum Beta-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae in Northeastern Thailand
by Sumontha Chaisaeng, Nattamol Phetburom, Pachara Kasemsiri, Nuntiput Putthanachote, Naowarut Wangnadee, Parichart Boueroy, Anusak Kerdsin and Peechanika Chopjitt
Antibiotics 2024, 13(10), 917; https://doi.org/10.3390/antibiotics13100917 - 25 Sep 2024
Cited by 1 | Viewed by 1118
Abstract
The global emergence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae presents a significant public health threat and complicates antibiotic treatment for infections. This study aimed to determine the prevalence of ESBL-producing K. pneumoniae in a clinical setting, analyze their antimicrobial susceptibility profiles, and characterize [...] Read more.
The global emergence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae presents a significant public health threat and complicates antibiotic treatment for infections. This study aimed to determine the prevalence of ESBL-producing K. pneumoniae in a clinical setting, analyze their antimicrobial susceptibility profiles, and characterize both phenotypic and genetic determinants. A total of 507 non-duplicate clinical isolates of Enterobacterales were collected between 2019 and 2020, and third-generation cephalosporin resistance was screened by disk diffusion. Identification of K. pneumoniae was confirmed using biochemical tests and PCR with species-specific primers. Antimicrobial susceptibility testing was conducted using disk diffusion, and phenotypic ESBL production was confirmed using the combined disk method. Multiplex PCR detected ESBL genes (blaTEM, blaSHV, and blaCTX-M) and identified blaCTX-M groups. The genetic relatedness of ESBL-producing strains was assessed using the ERIC-PCR approach. Fitty-four isolates were confirmed as ESBL producers, all classified as multidrug-resistant (MDR). All ESBL-producing K. pneumoniae isolates exhibited resistance to ampicillin and cefotaxime, with high resistance rates for ciprofloxacin (98.2%), azithromycin (94.4%), piperacillin–tazobactam (88.9%), and trimethoprim (83.3%). Genotypic analysis revealed blaCTX-M was present in 94.4% of isolates, blaSHV in 87%, and blaTEM in 55.5%. The blaCTX-M-1 group was the most prevalent, accounting for 96.1% of isolates. Co-harboring of blaCTX-M, blaSHV, and blaTEM occurred in 42.6% of isolates, with co-carrying of blaCTX-M, and blaSHV was observed in 23/54 isolates. The ERIC-PCR analysis revealed 15 distinct types, indicating high genetic diversity. These findings highlight the urgent need for ongoing monitoring to control the spread of ESBL among K. pneumoniae and emphasize the importance of early detection and appropriate antibiotic selection for effectively treating infection caused by these pathogens. Full article
(This article belongs to the Special Issue Insights into Antibiotics in Human, Animal, and Agriculture: Resistance, Determinant, and Treatment, 2nd Edition)
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