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Antibiotics
Special Issues
Nanomaterials as Antimicrobial Agents for Biomedical Applications
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Nanomaterials as Antimicrobial Agents for Biomedical Applications

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 4864

Special Issue Editors

Dr. Gabriela Dorcioman

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Guest Editor
National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania
Interests: thin films/coatings; laser deposition methods; organic/inorganic compounds for biomedical application; oxides thin films; hard coatings
Special Issues, Collections and Topics in MDPI journals
Dr. Valentina Grumezescu

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Guest Editor
National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania
Interests: nanomaterials; polymer nanocomposites; 2D and 3D materials; biopolymers; drug delivery; organic/inorganic hybrids; sol–gel chemistry; polymers synthesis; 3D bioprinting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Amongst public health, policies to fight against the spreading of multidrug-resistant pathogens and prevent the microbial contamination of different surfaces represent high priorities.

In recent years, (nano)materials that exhibit intrinsic antimicrobial activity in addition to having additive or synergic effects with antibiotics or other antimicrobials have been increasingly investigated and applied in several important fields, such as biomedicine (medical devices, protection equipment, surgery tools, human implants, etc.), the food industry (packaging), and surface cleaning, to prevent bacterial attachment and biofilm development.

Due to the rapid progress in nanotechnologies and depending on an application’s nature, materials with an antimicrobial effect derived from a large diversity of combinations (organic–organic, inorganic–organic, etc.) can be processed by different synthesis methods as nanoparticulates or nanostructured coatings.

The aim of this Special Issue is to offer to specialized readers a collection of research studies with the newest and most interesting results regarding nanostructured coatings that exhibit antibacterial properties.

  • Antimicrobial resistance.
  • Microbial contamination.
  • Nanostructured coatings.
  • Biofilm inhibition.
  • Nanomaterials.

Dr. Gabriela Dorcioman
Dr. Valentina Grumezescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

21 pages, 11964 KiB  
Article
Novel Antimicrobial Agents Based on Zinc-Doped Hydroxyapatite Loaded with Tetracycline
by Simona Liliana Iconaru, Daniela Predoi, Carmen Steluta Ciobanu, Catalin Constantin Negrila, Roxana Trusca, Steinar Raaen, Krzysztof Rokosz, Liliana Ghegoiu, Monica Luminita Badea and Carmen Cimpeanu
Antibiotics 2024, 13(9), 803; https://doi.org/10.3390/antibiotics13090803 - 25 Aug 2024
Viewed by 983
Abstract
In this paper, we present for the first time the development of zinc-doped hydroxyapatite enriched with tetracycline (ZnHApTe) powders and provide a comprehensive evaluation of their physico-chemical and biological properties. Various techniques such as X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron [...] Read more.
In this paper, we present for the first time the development of zinc-doped hydroxyapatite enriched with tetracycline (ZnHApTe) powders and provide a comprehensive evaluation of their physico-chemical and biological properties. Various techniques such as X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) were used for the sample’s complex evaluation. Moreover, the biocompatibility of zinc-doped hydroxyapatite (ZnHAp) and ZnHApTe nanoparticles was evaluated with the aid of human fetal osteoblastic cells (hFOB 1.19 cell line). The results of the biological assays suggested that these nanoparticles hold great promise as potential candidates for the future development of novel biocompatible and antimicrobial agents for biomedical applications. The antimicrobial properties of the ZnHAp and ZnHApTe nanoparticles were assessed using the standard reference microbial strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. The results of the in vitro antimicrobial assay demonstrated that both tested materials exhibited good antimicrobial activity. Additionally, these data also indicated that the antimicrobial effects of the ZnHAp nanoparticles were intensified by the presence of tetracycline (Te). Furthermore, the results also suggested that the antimicrobial activity of the samples increased with the incubation time. Full article
(This article belongs to the Special Issue Nanomaterials as Antimicrobial Agents for Biomedical Applications)
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20 pages, 6296 KiB  
Article
New Fe3O4-Based Coatings with Enhanced Anti-Biofilm Activity for Medical Devices
by Ioana Adelina Pirușcă, Paul Cătălin Balaure, Valentina Grumezescu, Stefan-Andrei Irimiciuc, Ovidiu-Cristian Oprea, Alexandra Cătălina Bîrcă, Bogdan Vasile, Alina Maria Holban, Ionela C. Voinea, Miruna S. Stan, Roxana Trușcă, Alexandru Mihai Grumezescu and George-Alexandru Croitoru
Antibiotics 2024, 13(7), 631; https://doi.org/10.3390/antibiotics13070631 - 7 Jul 2024
Viewed by 1504
Abstract
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause of morbidity and mortality. Herein, we present the fabrication, characterization, and in vitro evaluation of biocompatibility and anti-biofilm properties of [...] Read more.
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause of morbidity and mortality. Herein, we present the fabrication, characterization, and in vitro evaluation of biocompatibility and anti-biofilm properties of new coatings based on Fe3O4 nanoparticles (NPs) loaded with usnic acid (UA) and ceftriaxone (CEF). Sodium lauryl sulfate (SLS) was employed as a stabilizer and modulator of the polarity, dispersibility, shape, and anti-biofilm properties of the magnetite nanoparticles. The resulting Fe3O4 functionalized NPs, namely Fe3O4@SLS, Fe3O4@SLS/UA, and Fe3O4@SLS/CEF, respectively, were prepared by co-precipitation method and fully characterized by XRD, TEM, SAED, SEM, FTIR, and TGA. They were further used to produce nanostructured coatings by matrix-assisted pulsed laser evaporation (MAPLE) technique. The biocompatibility of the coatings was assessed by measuring the cell viability, lactate dehydrogenase release, and nitric oxide level in the culture medium and by evaluating the actin cytoskeleton morphology of murine pre-osteoblasts. All prepared nanostructured coatings exhibited good biocompatibility. Biofilm growth inhibition ability was tested at 24 h and 48 h against Staphylococcus aureus and Pseudomonas aeruginosa as representative models for Gram-positive and Gram-negative bacteria. The coatings demonstrated good biocompatibility, promoting osteoblast adhesion, migration, and growth without significant impact on cell viability or morphology, highlighting their potential for developing safe and effective antibacterial surfaces. Full article
(This article belongs to the Special Issue Nanomaterials as Antimicrobial Agents for Biomedical Applications)
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18 pages, 3512 KiB  
Article
A High-Performance Antibacterial Nanostructured ZnO Microfluidic Device for Controlled Bacterial Lysis and DNA Release
by Yvonni Xesfyngi, Maria Georgoutsou-Spyridonos, Abinash Tripathy, Athanasios Milionis, Dimos Poulikakos, Dimitrios C. Mastellos and Angeliki Tserepi
Antibiotics 2023, 12(8), 1276; https://doi.org/10.3390/antibiotics12081276 - 2 Aug 2023
Viewed by 1511
Abstract
In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which functions due to the action of its [...] Read more.
In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which functions due to the action of its nanostructured ZnO surfaces in contact with the working fluid. To shed light on the mechanism responsible for lysis, E. coli bacteria were incubated in zinc and nanostructured ZnO substrates, as well as the here-investigated ZnO-based microfluidic devices. The unprecedented killing efficiency of E. coli in nanostructured ZnO microchannels, effective after a 15 min incubation, paves the way for the implementation of such microfluidic chips in the disinfection of bacteria-containing solutions. In addition, the DNA release was confirmed by off-chip PCR and UV absorption measurements. The results indicate that the present nanostructured ZnO-based microfluidic chip can, under light, achieve partial inactivation of the released bacterial DNA via reactive oxygen species-mediated oxidative damage. The present device concept can find broader applications in cases where the presence of DNA in a sample is not desirable. Furthermore, the present microchannel device enables, in the dark, efficient release of bacterial DNA for downstream genomic DNA analysis. The demonstrated potential of this antibacterial device for tailored dual functionality in light/dark conditions is the main novel contribution of the present work. Full article
(This article belongs to the Special Issue Nanomaterials as Antimicrobial Agents for Biomedical Applications)
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