Antibiotics Use and Stewardship in Hospitals and Outpatient Care Facilities, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3097

Special Issue Editors


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Guest Editor
Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA
Interests: clinical trials; preclinical lab work including animal and invitro models; data collection and analysis; contributing to development; optimization and stewardship for antibacterial agents
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacology & Toxicology, Alalamein International University, Alexandria 51718, Egypt
Interests: metabolic dysfunction; low-grade inflammation; microbiota

Special Issue Information

Dear Colleagues,

The first edition of the Special Issue “Antibiotics Use and Stewardship in Hospitals and Outpatients Care Facilities” was published in 2023. It is a successful Special Issue with 19 papers and has encouraged us to open a second edition on the same topic.

As a continuation of the Special Issue published in 2023, the second edition will also explore the following fields:

  • Assessment of the prevalence and treatment outcomes of resistant phenotypes (ESBL, CRE, MRSA, and VRSA) in hospitalized patients;
  • Prevalence of concurrent infections, treatment outcome assessment, and ASP activities in special patient groups (immunocompromised patients; COVID-19 patients; pregnant women; neonates and pediatric patients; patients with genetic blood coagulopathy diseases (thalassemia, sickle cell, G6PD, etc.);
  • Impact of implementing rapid diagnostic tools for antimicrobial susceptibility testing;
  • Impact of implementing ASP strategies in outpatient and inpatient health facilities on infections, resistance patterns, healthcare costs, morbidity, and mortality rates;
  • Impact of the implementation of pre- and post-operative prophylaxis protocols;
  • Practices that improve antimicrobial stewardship and optimize outcomes;
  • Discovery of new antimicrobials or repurposing of existing antimicrobials.

Dr. Islam M. Ghazi
Prof. Dr. Ahmed El Yazbi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial stewardship
  • novel antibiotics
  • microbial resistance
  • optimizing treatment
  • pharmacokintics/pharmacodynamics

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Related Special Issue

Published Papers (2 papers)

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Research

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15 pages, 1304 KiB  
Article
Longitudinal Trends in In-Patient Antibiotic Consumption According to the WHO Access, Watch, Reserve (AWaRe) Antibiotic Groups and Cost: An Analysis of Data at a National Antimicrobial Consumption Network (NAC-NET) Site in North India over 7 Years (2017–2023)
by Niti Mittal, Ashish Tayal, Suneel Kumar, Reevanshi Dhawan, Nidhi Goel and Rakesh Mittal
Antibiotics 2024, 13(7), 673; https://doi.org/10.3390/antibiotics13070673 - 19 Jul 2024
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Abstract
(1) Background: Antibiotic surveillance data are crucial to map out strategies to promote their optimal use at hospital and community levels. We conducted a comprehensive analysis of longitudinal trends in antibiotic consumption over 7 years at a core “National Antimicrobial Consumption Network” site [...] Read more.
(1) Background: Antibiotic surveillance data are crucial to map out strategies to promote their optimal use at hospital and community levels. We conducted a comprehensive analysis of longitudinal trends in antibiotic consumption over 7 years at a core “National Antimicrobial Consumption Network” site in North India. (2) Methods: In-patient antibiotic consumption data (2017–2023) were obtained from the hospital’s central drug store and organised as follows: defined daily dose per 100 bed-days; antibiotic consumption as per the WHO access, watch and reserve classification; trends in overall and different antibiotic classes’ consumption; paediatric formulations of antibiotics; and hospital’s annual expenditure on antibiotics. (3) Results: During the 7-year study period, no significant trend could be observed in the overall antibiotic consumption (average annual percent change, AAPC: 9.22; 95% CI: −16.46, 34.9) and cost (AAPC: 13.55; −13.2, 40.3). There was a higher proportion of the consumption of antibiotics in the “reserve” group from 2021 onwards compared to previous years, but the overall trend over 7 years was not significant (AAPC: 319.75; −137.6, 777.1). Antibiotic combinations, classified under the WHO “not recommended” category, comprised a significant proportion of antibiotics consumed. A remarkably increased consumption of azithromycin and doxycycline was recorded during 2020 and 2021, coinciding with the COVID-19 pandemic. (4) Conclusions: Some recommendations to optimise antibiotic use are promoting the use of narrow spectrum “access” group agents; linking antimicrobial resistance and consumption data to formulate effective therapeutic and prophylactic antibiotic use guidelines; and the adoption of restrictive antibiotic policy. Full article
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8 pages, 533 KiB  
Brief Report
Impact of Education on Inappropriate Antibiotic Prescription for Respiratory Tract Infection Based on Physicians’ Justifications: A Web-Based Survey in Japan
by Ryohei Kudoh, Kosaku Komiya, Norihito Kaku, Yuichiro Shindo, Tatsuya Hayashi, Kei Kasahara, Tomohiro Oishi, Naruhiko Ishiwada, Makoto Ito, Hiroshi Yotsuyanagi, Naoki Hasegawa, Kazuhiro Tateda, Muneki Hotomi and Katsunori Yanagihara
Antibiotics 2024, 13(11), 1022; https://doi.org/10.3390/antibiotics13111022 - 30 Oct 2024
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Abstract
Background: Antibiotics are inappropriately prescribed for respiratory tract infections for various reasons. The differences of the effects of education based on these reasons has not been fully elucidated. This study assessed the impact of an educational film on antibiotic prescription patterns according [...] Read more.
Background: Antibiotics are inappropriately prescribed for respiratory tract infections for various reasons. The differences of the effects of education based on these reasons has not been fully elucidated. This study assessed the impact of an educational film on antibiotic prescription patterns according to physicians’ prescribing justifications. Methods: This was a secondary analysis of a nationwide web-based survey involving 1100 physicians. The physicians were required to view a short educational film and determine the need for prescribing antibiotics in simulated scenarios of different acute respiratory tract infectious diseases. The associations between the reasons for antibiotic prescription to patients not requiring antibiotics before viewing the educational film and the positive effects of the intervention were analyzed. Results: The educational intervention positively affected prescribing trends among physicians who prescribed antibiotics for “fever” in mild acute rhinosinusitis (prescription rates from 100% to 25.9%), “pus in the laryngopharynx” in mild acute pharyngitis (prescription rates from 100% to 29.6%), and “purulent sputum” in acute bronchitis without chronic lung disease (prescription rates from 100% to 29.9%) before viewing the film. In contrast, no benefits were observed when the justification was “patient’s desire for antibiotics” in mild acute pharyngitis (prescription rates from 100% to 48.5%) and acute bronchitis without chronic lung disease (prescription rates from 100% to 44.0%) or “parents’ desire for antibiotics” in narrowly defined common cold in children (prescription rates from 100% to 45.7%). Conclusions: although educational interventions might reduce inappropriate antibiotic prescription by providing accurate knowledge about respiratory tract infections, they appear ineffective for physicians who prescribe antibiotics based on patients’ or parents’ desires for antibiotic treatment. Full article
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