Drugs from Arthropods: Leveraging Antimicrobial Peptides from Arthropods

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 4371

Special Issue Editor


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Guest Editor
1. Institute for Insect Biotechnology, Department of Applied Entomology, Justus Liebig University, Giessen, Germany
2. LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Frankfurt, Germany
Interests: antimicrobial peptides; natural compounds; arthropod immunity; tropical diseases; vector-borne diseases

Special Issue Information

Dear Colleague,

Life-threatening infectious diseases remain among the leading causes of death in the human population worldwide. Multiple outbreaks of epidemic infectious diseases have occurred in the last few decades, including those caused by viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence or re-emergence of such diseases has revealed the deficiency in the pipeline for the discovery and development of anti-infective drugs. One promising solution is the extensive collection of antimicrobial peptides (AMPs), which are valuable because they have evolved for millions of years in multicellular organisms that rely on innate immunity to control and prevent pathogen infection. Arthropods produce the broadest repertoire of AMPs, and their potent antimicrobial, antifungal, antiparasitic, antiviral, and even anticancer, activities in vitro and in vivo have promoted their development as therapeutics. The biotechnological application of arthropod AMPs requires the development of innovative approaches for production, testing and modification of these fascinating molecules.

In this Special Issue, we invite you to prepare and submit your manuscripts describing the chemistry of AMPs from arthropods, their biological activities and modes of action, AMP mimetics and related topics.

Dr. Miray Tonk
Guest Editor

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Keywords

  • antimicrobial peptides
  • host-defense peptides
  • antiinfective
  • antibacterial
  • antibiofilm
  • antifungal
  • antiviral
  • antiparasitic
  • anticancer
  • AMPs with synergistic activities

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Published Papers (1 paper)

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Research

28 pages, 12535 KiB  
Article
LyeTx I-b Peptide Attenuates Tumor Burden and Metastasis in a Mouse 4T1 Breast Cancer Model
by Mostafa A. L. Abdel-Salam, Bárbara Pinto, Geovanni Cassali, Lilian Bueno, Gabriela Pêgas, Fabrício Oliveira, Irismara Silva, André Klein, Elaine Maria de Souza-Fagundes, Maria Elena de Lima and Juliana Carvalho-Tavares
Antibiotics 2021, 10(9), 1136; https://doi.org/10.3390/antibiotics10091136 - 21 Sep 2021
Cited by 11 | Viewed by 3512
Abstract
Cationic anticancer peptides have exhibited potent anti-proliferative and anti-inflammatory effects in neoplastic illness conditions. LyeTx I-b is a synthetic peptide derived from Lycosa erythrognatha spider venom that previously showed antibiotic activity in vitro and in vivo. This study focused on the effects of [...] Read more.
Cationic anticancer peptides have exhibited potent anti-proliferative and anti-inflammatory effects in neoplastic illness conditions. LyeTx I-b is a synthetic peptide derived from Lycosa erythrognatha spider venom that previously showed antibiotic activity in vitro and in vivo. This study focused on the effects of LyeTxI-b on a 4T1 mouse mammary carcinoma model. Mice with a palpable tumor in the left flank were subcutaneously or intratumorally injected with LyeTx I-b (5 mg/kg), which significantly decreased the tumor volume and metastatic nodules. Histological analyses showed a large necrotic area in treated primary tumors compared to the control. LyeTxI-b reduced tumor growth and lung metastasis in the 4T1 mouse mammary carcinoma model with no signs of toxicity in healthy or cancerous mice. The mechanism of action of LyeTx I-b on the 4T1 mouse mammary carcinoma model was evaluated in vitro and is associated with induction of apoptosis and cell proliferation inhibition. Furthermore, LyeTx I-b seems to be an efficient regulator of the 4T1 tumor microenvironment by modulating several cytokines, such as TGF-β, TNF-α, IL-1β, IL-6, and IL-10, in primary tumor and lung, spleen, and brain. LyeTx I-b also plays a role in leukocytes rolling and adhesion into spinal cord microcirculation and in the number of circulating leukocytes. These data suggest a potent antineoplastic efficacy ofLyeTx I-b. Full article
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