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Antibiotics
Special Issues
Antimicrobial and Antibiofilm Activity of Nanomaterials: From Bacteria to Yeast
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Antimicrobial and Antibiofilm Activity of Nanomaterials: From Bacteria to Yeast

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 6467

Special Issue Editors

Dr. Roberto Vazquez-Munoz

E-Mail Website
Guest Editor
University of Connecticut Health Center, Farmington, CT, USA
Interests: antimicrobial metallic nanoparticles; biofilms; microbiome; nanotoxicology
Dr. Lourdes Bazán-Díaz

E-Mail Website
Guest Editor
Materials Research Institute, National Autonomous University of Mexico, Mexico City, Mexico
Interests: nanoparticles; synthesis of nanoparticles

Special Issue Information

Dear Colleagues,

The recent surge of Multi-Drug Resistant diseases and the current COVID-19 pandemic have exposed our vulnerability to infectious diseases and the urgency of developing novel solutions. As of today, infections are among the leading causes of death in developed and developing countries. Bacteria and fungal infections negatively impact health, life quality, food production, and transportation. In particular, biofilm-forming microorganisms pose an additional risk in healthcare and food-processing settings. Antimicrobial nanomaterials are a promising approach to combat pathogens and disrupt bacterial and fungal biofilms. Current research highlights antimicrobial nanomaterials' use to detect, prevent, and combat pathogens and biofilms. In addition, some nanomaterials display synergistic effects when combined with antimicrobial drugs and disinfectants.

This Special Issue seeks manuscript submissions that expand our understanding of the impact of antimicrobial nanomaterials on microbial cell physiology and structure, biofilms, the microbiome, and antimicrobial drugs/antiseptics/disinfectants. Submissions that address the interactions between antimicrobial nanomaterials and microbial cells are particularly encouraged.

Dr. Roberto Vazquez-Munoz
Dr. Lourdes Bazán-Díaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial nanomaterials
  • antibiofilm
  • microbiome
  • drug resistance
  • nanotoxicity

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Published Papers (3 papers)

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Research

14 pages, 3099 KiB  
Article
Antimicrobial Activity of Green Synthesized Silver and Copper Oxide Nanoparticles against the Foodborne Pathogen Campylobacter jejuni
by Daniel Rivera-Mendoza, Beatriz Quiñones, Alejandro Huerta-Saquero and Ernestina Castro-Longoria
Antibiotics 2024, 13(7), 650; https://doi.org/10.3390/antibiotics13070650 - 14 Jul 2024
Cited by 2 | Viewed by 1318
Abstract
Campylobacter jejuni is a major cause of global foodborne illnesses. To develop alternative antimicrobial strategies against C. jejuni, this study designed and optimized the green synthesis of metallic nanoparticles (NPs) with intracellular components of the medicinal fungus Ganoderma sessile to provide the [...] Read more.
Campylobacter jejuni is a major cause of global foodborne illnesses. To develop alternative antimicrobial strategies against C. jejuni, this study designed and optimized the green synthesis of metallic nanoparticles (NPs) with intracellular components of the medicinal fungus Ganoderma sessile to provide the needed reducing and stabilizing agents. NPs were characterized by transmission electron microscopy and dynamic light scattering, and the quasi-spherical NPs had sizes of 2.9 ± 0.9 nm for the copper oxide NPs and 14.7 ± 0.6 nm for the silver NPs. Surface charge assessment revealed zeta potentials of −21.0 ± 6.5 mV and −24.4 ± 7.9 mV for the copper oxide and silver NPs, respectively. The growth inhibition of C. jejuni by the NPs occurred through attachment to the outer cell membrane and subsequent intracellular internalization and resulted in minimum inhibitory concentrations of the silver NPs at 6 µg/mL and copper oxide NPs at 10 µg/mL. On the other hand, a differential ROS production caused by silver and copper NPs was observed. In summary, this research presents the first demonstration of using green synthesis with the medicinal fungus G. sessile to produce metallic NPs that effectively inhibit C. jejuni growth, providing a sustainable and effective approach to the traditional use of antimicrobials. Full article
(This article belongs to the Special Issue Antimicrobial and Antibiofilm Activity of Nanomaterials: From Bacteria to Yeast)
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21 pages, 11068 KiB  
Article
Magnetite-Based Nanostructured Coatings Functionalized with Nigella sativa and Dicloxacillin for Improved Wound Dressings
by Gabriela Dorcioman, Ariana Hudiță, Bianca Gălățeanu, Doina Craciun, Ionel Mercioniu, Ovidiu Cristian Oprea, Irina Neguț, Valentina Grumezescu, Alexandru Mihai Grumezescu, Lia Mara Dițu and Alina Maria Holban
Antibiotics 2023, 12(1), 59; https://doi.org/10.3390/antibiotics12010059 - 29 Dec 2022
Viewed by 2290
Abstract
In this study, we report the performance improvement of wound dressings by covering them with magnetite-based nanostructured coatings. The magnetite nanoparticles (Fe3O4 NPs) were functionalized with Nigella sativa (N. sativa) powder/essential oil and dicloxacillin and were synthesized as [...] Read more.
In this study, we report the performance improvement of wound dressings by covering them with magnetite-based nanostructured coatings. The magnetite nanoparticles (Fe3O4 NPs) were functionalized with Nigella sativa (N. sativa) powder/essential oil and dicloxacillin and were synthesized as coatings by matrix assisted pulsed laser evaporation (MAPLE). The expected effects of this combination of materials are: (i) to reduce microbial contamination, and (ii) to promote rapid wound healing. The crystalline nature of core/shell Fe3O4 NPs and coatings was determined by X-ray diffraction (XRD). Differential Scanning Calorimetry (DSC) and Thermo Gravimetric Analysis (TGA) have been coupled to investigate the stability and thermal degradation of core/shell nanoparticle components. The coatings’ morphology was examined by scanning electron microscopy (SEM). The distribution of chemical elements and functional groups in the resulting coatings was evidenced by Fourier transform infrared (FTIR) spectrometry. In order to simulate the interaction between wound dressings and epithelial tissues and to evaluate the drug release in time, the samples were immersed in simulated body fluid (SBF) and investigated after different durations of time. The antimicrobial effect was evaluated in planktonic (free-floating) and attached (biofilms) bacteria models. The biocompatibility and regenerative properties of the nanostructured coatings were evaluated in vitro, at cellular, biochemical, and the molecular level. The obtained results show that magnetite-based nanostructured coatings functionalized with N. sativa and dicloxacillin are biocompatible and show an enhanced antimicrobial effect against Gram positive and Gram negative opportunistic bacteria. Full article
(This article belongs to the Special Issue Antimicrobial and Antibiofilm Activity of Nanomaterials: From Bacteria to Yeast)
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17 pages, 2847 KiB  
Article
Metabolomic Profiling of the Responses of Planktonic and Biofilm Vibrio cholerae to Silver Nanoparticles
by Anaid Meza-Villezcas, Rommel A. Carballo-Castañeda, Aldo Moreno-Ulloa and Alejandro Huerta-Saquero
Antibiotics 2022, 11(11), 1534; https://doi.org/10.3390/antibiotics11111534 - 2 Nov 2022
Cited by 1 | Viewed by 2002
Abstract
Vibrio cholerae causes cholera and can switch between planktonic and biofilm lifeforms, where biofilm formation enhances transmission, virulence, and antibiotic resistance. Due to antibiotic microbial resistance, new antimicrobials including silver nanoparticles (AgNPs) are being studied. Nevertheless, little is known about the metabolic changes [...] Read more.
Vibrio cholerae causes cholera and can switch between planktonic and biofilm lifeforms, where biofilm formation enhances transmission, virulence, and antibiotic resistance. Due to antibiotic microbial resistance, new antimicrobials including silver nanoparticles (AgNPs) are being studied. Nevertheless, little is known about the metabolic changes exerted by AgNPs on both microbial lifeforms. Our objective was to evaluate the changes in the metabolomic profile of V. cholerae planktonic and biofilm cells in response to sublethal concentrations of AgNPs using MS2 untargeted metabolomics and chemoinformatics. A total of 690 metabolites were quantified among all groups. More metabolites were significantly modulated in planktonic cells (n = 71) compared to biofilm (n = 37) by the treatment. The chemical class profiles were distinct for both planktonic and biofilm, suggesting a phenotype-dependent metabolic response to the nanoparticles. Chemical enrichment analysis showed altered abundances of oxidized fatty acids (FA), saturated FA, phosphatidic acids, and saturated stearic acid in planktonic cells treated with AgNPs, which hints at a turnover of the membrane. In contrast, no chemical classes were enriched in the biofilm. In conclusion, this study suggests that the response of V. cholerae to silver nanoparticles is phenotype-dependent and that planktonic cells experience a lipid remodeling process, possibly related to an adaptive mechanism involving the cell membrane. Full article
(This article belongs to the Special Issue Antimicrobial and Antibiofilm Activity of Nanomaterials: From Bacteria to Yeast)
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