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Antibiotics
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Research Advances in Antimicrobial Stewardship, Residues and Resistance in Veterinary...
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Research Advances in Antimicrobial Stewardship, Residues and Resistance in Veterinary and Environmental Science

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 927

Special Issue Editors

Dr. Justine S. Gibson

E-Mail Website
Guest Editor
Queensland Alliance for One Health Sciences, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia
Interests: veterinary infectious diseases; antimicrobial resistance; antimicrobial stewardship; infection control; zoonotic diseases
Dr. Ricardo J. Soares Magalhães

E-Mail Website
Guest Editor
Queensland Alliance for One Health Sciences, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia
Interests: veterinary public health; zoonotic diseases epidemiology; animal biosecurity; one health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) threatens human, animal, and environmental health, underscoring the need for advancing antimicrobial stewardship (AMS) in the veterinary sciences. This Special Issue highlights cutting-edge research that addresses this global challenge from a veterinary science perspective, considering critical facets of AMR, including antimicrobial residues (ARs) and AMS’ effect on animal health.

Contributions to this Special Issue may explore at-risk epidemiological groups, novel diagnostic tools, innovative therapeutic approaches, and integrated management strategies for reducing antimicrobial use while maintaining animal welfare and productivity. Studies could also focus on the environmental and public health dimensions of ARs in agricultural systems, presenting data-driven approaches to mitigate their impacts on human health and ecosystems.

Insights from studies on interdisciplinary and transectoral collaborations should demonstrate how coordinated efforts across veterinary, medical, and environmental sectors can strengthen stewardship practices to achieve a One Health outcome. This Special Issue also features case studies showcasing the successful implementation of antimicrobial stewardship programs in diverse veterinary and environmental contexts, as well as policy-focused analyses offering frameworks for sustainable, cross-sectoral AMR and AR mitigation strategies.

By bridging research, practice and policy, this Special Issue provides a comprehensive collection of studies showcasing the latest methodological advancements, operational challenges, and policy opportunities for combating AMR and ARs. Studies included in this Special Issue will serve as an important resource for veterinarians, researchers, policymakers, and environmental industry stakeholders committed to safeguarding the efficacy of antimicrobials for animal patients and the community.

Dr. Justine S. Gibson
Dr. Ricardo Magalhães
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance (AMR)
  • antimicrobial stewardship (AMS)
  • antimicrobial residues (ARs)
  • diagnostic tools and therapeutics
  • epidemiology
  • sustainable AMR mitigation
  • one health
  • veterinary sciences

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Published Papers (1 paper)

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18 pages, 3033 KiB  
Article
The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal
by Erda E. Rame Hau, Minu Sharma, Bal K. Sharma Khanal, Peter D. Sly, Deirdre Mikkelsen, Nicholas Clark and Ricardo J. Soares Magalhães
Antibiotics 2025, 14(1), 98; https://doi.org/10.3390/antibiotics14010098 - 16 Jan 2025
Viewed by 808
Abstract
Background/Objectives: The presence of antibiotic residues (ARs) in animal products such as milk can be an important driver of antimicrobial resistance in commensal and pathogenic bacteria. Previous studies on ARs in Nepal have demonstrated the presence of ARs in milk samples but without [...] Read more.
Background/Objectives: The presence of antibiotic residues (ARs) in animal products such as milk can be an important driver of antimicrobial resistance in commensal and pathogenic bacteria. Previous studies on ARs in Nepal have demonstrated the presence of ARs in milk samples but without further characterization of the samples for risk factor analysis. This study aimed to quantify the prevalence and risk factors for the presence of ARs in 140 peri-urban dairy farms in Kathmandu, Nepal, included in a cross-sectional survey in 2019 to estimate farm-level AR prevalence. Results: Our results reveal the presence of ARs of sulfamethazine (61%), sulfamethoxazole (53%), ciprofloxacin (46%), and enrofloxacin (42%). Furthermore, of those samples positive for sulfamethazine, sulfamethoxazole, and ciprofloxacin, 81%, 42%, and 42%, respectively, exceeded the maximum residue limit (MRL). While samples taken from farms where staff administered antibiotics were less likely to have single drug residues and multidrug residues (two, three, and four drugs), farms with more workers were more likely to have single residues. Moreover, samples from farms with a higher number of calves and milking cows were more likely to contain single and multiple residues exceeding the MRL, while milk from farms with higher numbers of dry cows and farmers reported by a visiting chemist were less likely to have multidrug residues exceeding the MRL. Methods: High-performance liquid chromatography was conducted on bulk milk samples from farms for an AR analysis, revealing positive results. Additionally, a structured questionnaire and direct farmer interviews were used to collect data on farm biosecurity and farming practices, animal health and hygiene, antibiotic usage (AMU), and attitudes and practices towards antibiotic stewardship. Conclusions: Ultimately, this study provides evidence on the role of modifiable ARs risk factors in the peri-urban milk industry of Kathmandu, which can serve as a foundation for developing improved antimicrobial stewardship guidelines and designing intervention measures to reduce the public health risk posed by ARs in milk sold in Kathmandu, Nepal. Full article
(This article belongs to the Special Issue Research Advances in Antimicrobial Stewardship, Residues and Resistance in Veterinary and Environmental Science)
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