Antibiotic Therapy Optimization in Special Populations
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5452
Special Issue Editors
Interests: clinical pharmacokinetics; pharmacodynamics; clinical pharmacometrics; critical care; sepsis; obesity; drug therapy optimization
Interests: obstetric clinical pharmacology; pharmacometrics; drug metabolism; pediatric pharmacology; pharmacokinetics; pharmacodynamics; physiologically based pharmacokinetic modeling, drug-drug interactions, personalized medicine
Special Issue Information
Dear Colleagues,
In the era of antibiotic resistance, with few novel antimicrobial agents in the clinical pipeline, the importance of appropriate antibiotic use cannot be emphasized enough. One of the contributing factors to inappropriate antibiotic use is inadequate consideration of patient characteristics to design an individualized dosing regimen. Failure of the “one size fits all” theory to achieve optimal clinical outcomes is now evident, and the practice of medicine is moving toward individualized precision medicine. The primary reason for the failure of the “one size fits all” theory is substantial pharmacokinetic and pharmacodynamic variability among various patient populations.
Individualized precision antibiotic therapy is critical to optimize treatment outcomes because sufficient antimicrobial concentrations are imperative to achieve maximal killing activity, but excessive concentrations should be avoided in order to minimize antibiotic-associated toxicities. However, the design of optimal individualized antibiotic therapy regimen is particularly complicating for the patient populations whose gradual or acute pathophysiologic alterations substantially impact antimicrobial pharmacokinetics and pharmacodynamics. These patient populations are collectively called special populations and include critically ill patients, elderly populations, obese individuals, pediatric populations, immunocompromised patients, pregnant individuals, and patients with impaired organ functions. In these special populations, antibiotic clearance and volume of distribution are substantially different compared to general populations, requiring alternative antimicrobial dosing regimen. Additionally, change in their disease course over time affects intra-individual pharmacokinetic variability, resulting in continuous dosage adjustment in these patient populations. With the advancement of data computation technology and elaborate understanding of pathophysiology, scientific data contributing to the design of optimal antibiotic therapy are exponentially increasing.
In this Special Issue, scientific advances in designing optimal antibiotic therapy considering various patient characteristics will be discussed focusing on the aforementioned special patient populations. The multidisciplinary efforts in the field of antibiotic pharmacotherapy such as clinical pharmacokinetics and pharmacodynamics will provide insight for clinician scientists and healthcare professionals regarding the optimal antimicrobial therapy for special patient populations.
We look forward to your contributions to this important area of clinical practice and research.
Dr. Eun Kyoung Chung
Prof. Dr. Sara K. Quinney
Guest Editors
Manuscript Submission Information
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Keywords
- clinical pharmacometrics
- PK/PD optimization of antibiotic therapy
- special populations
- critically ill patients
- elderly populations
- obesity
- immunocompromised patients
- pediatric populations
- pregnancy
- patients with impaired organ function
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