Monoclonal Antibody-Based Agents in Cancer Treatment: From Laboratory to the Clinic
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (15 December 2014) | Viewed by 11283
Special Issue Editor
Interests: therapeutic and diagnostic antibodies; cancer therapy; discovery of therapeutic targets
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the past 28 years, several monoclonal antibody-based drugs have been approved for the treatment of a wide range of human diseases and, in particular, human cancers. At present, 16 antibodies of murine, chimeric, humanised, and fully human formats have been approved for the treatment of cancer patients in the USA and European Union. In 2011, the top three best-selling cancer drugs were monoclonal antibodies, namely anti-CD20 rituximab, anti-VEGF bevacizumab, and anti-HER-2 trastuzumab with sales of $3 billion, $2.66 billion and $1.66 billion, respectively. In addition, hundreds of antibody-based products are currently at different stages of preclinical development or clinical trials.
This Special Issue of therapeutic antibodies will highlight these advances, some of the challenges (e.g., resistance to antibody therapy, the high cost of therapeutic antibodies), as well as future opportunities for more effective and routine usage of antibody-based products in the treatment of cancer patients. It will contain the latest original data and reviews of approved therapeutic antibodies, and other promising antibody-based products which are at different stages of clinical trials or preclinical development. The therapeutic potential of other antibody formats in cancer (e.g., shark antibodies, IgE antibodies, antibody fragments, conjugated-antibodies), and the usage of alternative strategies for the production of less expensive therapeutic antibodies, will also be covered in this issue.
Prof. Dr. Helmout Modjtahedi
Guest Editor
Manuscript Submission Information
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Keywords
- therapeutic antibodies
- naked antibodies
- fragmented therapeutic antibodies
- conjugated antibodies
- antibody in discovery of novel antigens
- IgE antibodies
- shark Antibodies
- antibodies in transgenic plants
- antibodies in transgenic animals
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