Redox Biology of Glyoxalases and Advanced Glycation End Products in Health and Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 74
Special Issue Editors
Interests: glyoxalases; methylglyoxal; advanced glycation end products; oxidative stress; antioxidants; oncology; rare diseases; toxicology; apoptosis; epithelial-to-mesenchymal transition; epigenetics; epidemiology
Special Issues, Collections and Topics in MDPI journals
Interests: vaccines; microbiota; cystic fibrosis; inflammation; oxidative stress; glyoxalases; immunomodulation
Special Issue Information
Dear Colleagues,
Glyoxalases are enzymes that play a major role in the detoxification of reactive carbonyl compounds, primarily methylglyoxal (MGO), a potent glycating agent generated from different metabolic pathways, especially glycolysis. Glyoxalases comprise glyoxalase 1 (Glo1) and glyoxalase 2 (Glo2) enzymes. Glo1 catalyzes the conversion of MGO to S-D-lactoylglutathione using glutathione (GSH) as a cofactor. Glo2 hydrolyzes this product to regenerate GSH and form lactic acid. As a powerful glycating agent, MGO forms a heterogeneous family of advanced glycation end products (AGEs) that, both in normal and pathologic processes, induce different biological responses, including oxidative stress and inflammation, often associated with aging, diabetes, cancer, neurodegenerative, cardio- and cerebrovascular diseases, and rare diseases. However, there is also evidence suggesting that certain MGO-derived AGEs possess antioxidant properties. These seemingly distinct functions suggest that MGO-derived AGEs, and by extension glyoxalases, could have varying or even contradictory biological effects within cells, often depending on the specific context. On the other hand, new redox-dependent mechanisms are emerging within the intricate network that regulates glyoxalases and MGO-derived AGEs.
For this Special Issue, we invite researchers to submit original research or review articles exploring the relationship between Glo1, Glo2, MGO-derived AGEs, and redox biology in the context of various fields of applied biology, including cell and molecular biology, health sciences, plant sciences, toxicology, and microbiology. Submissions are also encouraged that address the discovery of novel non-enzymatic roles for glyoxalases, and the development of safe, effective, and innovative preventive or therapeutic strategies, including nutraceutical approaches to regulating the redox-dependent modulation of glyoxalases and/or MGO-derived AGEs, with potential implications for preventing cell and tissue dysfunction.
We hope this Special Issue will serve as a platform for sharing and disseminating the latest discoveries on the fascinating and rapidly evolving field of redox biology in relation to these eclectic enzymes.
We look forward to receiving your contributions.
Prof. Dr. Cinzia Antognelli
Dr. Marilena Pariano
Prof. Vincenzo Nicola Talesa
Guest Editors
Manuscript Submission Information
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Keywords
- glyoxalases
- methylglyoxal
- advanced glycation end products
- aging
- diseases
- antioxidants
- apoptosis
- cell proliferation
- nutraceuticals
- oxidative stress
- inflammation
- apoptosis
- EMT
- cell proliferation
- signal transduction
- biological mechanisms
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