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Recent Advances in Nanocarrier-Based Drug Delivery Systems

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2707

Special Issue Editor


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Guest Editor
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia
Interests: nanocarrier based drug delivery; solubility; bioavailability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The research scientists in pharmaceutical industries and research institutions are continuously developing improved drug formulations which could increase the therapeutic benefits and tolerability for the patient. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damage to the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site.

This Special Issue focuses on the recent development of a number of nanocarriers, including nanoparticles, nanoemulsion, liposomes, micelles, dendrimers, meso-porous silica, gold nanoparticles, super-paramagnetic iron-oxide nanoparticles, carbon nanotubes, and quantum dots. These nanocarrier drug delivery systems have the potential to significantly increase the therapeutic efficacy of drugs/molecules while minimizing their toxicity and adverse effects. Furthermore, these systems can be utilized as more intricate systems, alter multiple pathways, or circumvent drug resistance or multidrug resistance mechanisms in various diseases.

Dr. Md. Khalid Anwer
Guest Editor

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Keywords

  • nanotechnology, nanocarrier
  • drug delivery, drug targeting

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Published Papers (1 paper)

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Research

15 pages, 3209 KiB  
Article
Development and Characterization of Ibrutinib-Loaded Ethylcellulose-Based Nanosponges: Cytotoxicity Assay against MCF-7 Cell Lines
by Farhat Fatima and Md. Khalid Anwer
Appl. Sci. 2023, 13(8), 4984; https://doi.org/10.3390/app13084984 - 15 Apr 2023
Cited by 2 | Viewed by 2368
Abstract
Ibrutinib (ITB) is a specific and novel irreversible inhibitor of Bruton’s tyrosine kinase enzyme, for which reason it exhibits potential chemotherapeutic effects against a few types of B-cell cancers. The objective of this study was to design and characterize the targeted anti-cancer moiety [...] Read more.
Ibrutinib (ITB) is a specific and novel irreversible inhibitor of Bruton’s tyrosine kinase enzyme, for which reason it exhibits potential chemotherapeutic effects against a few types of B-cell cancers. The objective of this study was to design and characterize the targeted anti-cancer moiety of ITB encapsulated in polymeric nanosponges (IBNS 1-5). The IBNSs were fabricated using the ultrasonication-assisted solvent evaporation technique. They were optimized for robust nanocarriers by varying the ratio of ethylcellulose (50–200 mg), using a constant amount 50 mg of polyvinyl alcohol ((PVA) stabilizer), and drug ITB. Optimized INBS4 containing 50 mg of ITB, PVA, and 162.5 mg of EC was prepared and was studied for anti-cancer potential. Particle analysis and EE and DL calculation of optimized IBNS4 were 640.9 nm, 0.35, −30.2 mV in size, PDI, and ζp, respectively. Physicochemical characterization (FTIR and DSC) studies of IBNS4 showed that the drug was compatible with excipients, and was encapsulated properly within the core of nanosponges. In vitro drug release studies revealed that IBNS4 followed the Higuchi matrix model with anomalous non-Fickian release kinetics. The in vitro diffusion study of I-NS4 exhibited sustained release for 24 h. Enhanced cytotoxicity effects against the MCF-7 observed with the developed NSs (IBNS4) showed 1.96 times more cytotoxic potential compared to the pure drug (ITB). Full article
(This article belongs to the Special Issue Recent Advances in Nanocarrier-Based Drug Delivery Systems)
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