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Applied Sciences
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3D Printing in Bio-Medical Applications
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3D Printing in Bio-Medical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (20 August 2022) | Viewed by 17675

Special Issue Editor

Dr. Nima E. Gorji

E-Mail Website
Guest Editor
School of Manufacturing, Tech. University Dublin, D15YV78 Dublin, Ireland
Interests: solar cells; photovoltaics; nano-fabrication; optoelectronics; solid-state electronics; semiconductor physics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

3D printing additive manufacturing has now attracted the attention of biomedical engineers. There are a variety of applications for additive manufacturing technology available to surgeons at this moment. This Special Issue aims to understand the basic concept of 3D bioprinting as a tool for producing a 3D structure combining living cells and biomaterials and controlling cell proliferation, attachment, and migration within 3D structures. We also consider tissue engineering developed on a widespread basis in the fields of regeneration, restoration, or replacement of defective or injured functional living organs and tissues. We accept manuscripts on 3D printing of scaled models for preoperative planning based prosthetics or custom implants and biocompatible scaffolds. We will also consider manuscripts on 3D printing application to improve surgical and medical education, by using simulation models and using its potential to replicate complex anatomy by employing distinct materials that mimic the characteristics of the native tissue in an effort to increase patient safety through repetition of common procedures.

Prof. Dr. Nima E. Gorji
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • additive manufacturing
  • tissue engineering
  • bioprinting
  • biomedical devices
  • regenerative medicine
  • biocompatible 3D printing
  • implants

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Published Papers (5 papers)

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Research

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17 pages, 23407 KiB  
Article
Modeling and Simulation Process via Incremental Methods of a Production-Aimed Upper Limb Prosthesis
by Christopher René Torres-SanMiguel
Appl. Sci. 2022, 12(6), 2788; https://doi.org/10.3390/app12062788 - 9 Mar 2022
Cited by 3 | Viewed by 2680
Abstract
This research presents a numerical analysis used for designing an upper limb prosthesis with seven degrees of freedom (DOF). The process was undertaken to carry out the manufacture. The detailed methodology exposes a static structural analysis with the materials for manufacturing a prototype, [...] Read more.
This research presents a numerical analysis used for designing an upper limb prosthesis with seven degrees of freedom (DOF). The process was undertaken to carry out the manufacture. The detailed methodology exposes a static structural analysis with the materials for manufacturing a prototype, the components responsible for the movement of the prosthesis subject to maximum loads during simplified routines were optimized. The results show the classification of the pieces manufactured by an additive method and those made by material removal. Full article
(This article belongs to the Special Issue 3D Printing in Bio-Medical Applications)
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20 pages, 3436 KiB  
Article
Optimized Cell Mixing Facilitates the Reproducible Bioprinting of Constructs with High Cell Viability
by Axel Pössl, David Hartzke, Peggy Schlupp and Frank E. Runkel
Appl. Sci. 2022, 12(1), 326; https://doi.org/10.3390/app12010326 - 30 Dec 2021
Cited by 2 | Viewed by 2390
Abstract
Bioprinting with cell-laden hydrogels (bioink) requires the careful mixing of cells with the hydrogel carrier to ensure that the bioink is homogeneous and functional, and the printing results are reproducible. Bioink preparation is therefore a critical process step that must accommodate the specific [...] Read more.
Bioprinting with cell-laden hydrogels (bioink) requires the careful mixing of cells with the hydrogel carrier to ensure that the bioink is homogeneous and functional, and the printing results are reproducible. Bioink preparation is therefore a critical process step that must accommodate the specific rheological properties of different bioinks. Here, we developed a reproducible method for the optimized mixing of cells and hydrogel carriers that can be integrated into current bioprinting processes. First, we tested and optimized different mixing devices for their effect on bioink homogeneity and rheological properties, resulting in a low-shear process for the preparation of homogenous bioinks. Based on these findings, we evaluated the impact of different cell densities on the rheological profile of bioinks according to shear and temperature, and estimated the impact of shear stress intensity and duration on 1.1B4 cells. Finally, we integrated the optimized mixing method into a current printing process and monitored the printed construct for 14 days to confirm cell viability. We found that the cell viability in the printed cell-laden constructs remained in excess of 91% after 14 days. Full article
(This article belongs to the Special Issue 3D Printing in Bio-Medical Applications)
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Graphical abstract

9 pages, 3021 KiB  
Article
Strength Evaluation and Modification of a 3D Printed Anterior Ankle Foot Orthoses
by Yi-Chen Lin, Li-Ying Huang and Chen-Sheng Chen
Appl. Sci. 2020, 10(20), 7289; https://doi.org/10.3390/app10207289 - 18 Oct 2020
Cited by 7 | Viewed by 3602
Abstract
Ankle foot orthosis (AFO) is widely used to prevent foot drop and improve walking ability for individuals with cerebral palsy and stroke. However, traditional anterior AFO (TAAFO) could only last within months because the bilateral neck of TAAFO was easy to break. Currently, [...] Read more.
Ankle foot orthosis (AFO) is widely used to prevent foot drop and improve walking ability for individuals with cerebral palsy and stroke. However, traditional anterior AFO (TAAFO) could only last within months because the bilateral neck of TAAFO was easy to break. Currently, a 3D-printing technique is used to develop assistive devices for rehabilitation. The study aimed to implement the finite element (FE) method to revise the 3D printed AAFO (3DP-AAFO) and evaluate its strength. A 3.2 mm-thickness for the TAAFOs and 3DP-AAFOs were fabricated, respectively. The stiffness of TAAFO and 3DP-AAFO were tested by a material machine and compared to the FE model. In the FE analysis, the thickness of AAFO model was increased at the neck to enhance its strength. A plantarflexion and dorsiflexion moment were respectively subjected to 3DP-AAFO models to undergo stress analysis. Under the mechanical test, the 3DP-AAFO (K = 1.09 Nm/degree) was 7.8 times stiffer than the traditional AAFO (K = 0.14 Nm/degree). The FE results showed that thickening the 3DP-AAFO on the neck up to 4.7 mm could moderate stress concentration and increase the stiffness of the 3DP-AAFO. Therefore, the study concluded that the 3DP-AAFO was stiffer than the traditional AAFO. Increasing the appropriate thickness around neck of 3DP-AAFO could avoid neck fracture as much as possible. Full article
(This article belongs to the Special Issue 3D Printing in Bio-Medical Applications)
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Review

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45 pages, 3369 KiB  
Review
Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review
by Egemen Umur, Emirhan Bayrak, Fahriye Arslan, Safiye Betül Bulut, Engin Baysoy, Gizem Kaleli-Can and Bugra Ayan
Appl. Sci. 2023, 13(18), 10269; https://doi.org/10.3390/app131810269 - 13 Sep 2023
Cited by 10 | Viewed by 4756
Abstract
The vulnerability of skin wounds has made efficient wound dressing a challenging issue for decades, seeking to mimic the natural microenvironment of cells to facilitate cell binding, augmentation, and metamorphosis. Many three-dimensional (3D) bioprinted hydrogel-based configurations have been developed using high-tech devices to [...] Read more.
The vulnerability of skin wounds has made efficient wound dressing a challenging issue for decades, seeking to mimic the natural microenvironment of cells to facilitate cell binding, augmentation, and metamorphosis. Many three-dimensional (3D) bioprinted hydrogel-based configurations have been developed using high-tech devices to overcome the limitations of traditional dressing materials. Based on a material perspective, this review examines current state-of-the-art 3D bioprinting for hydrogel-based dressings, including both their advantages and limitations. Accordingly, their potential applications in terms of their performance in vitro and in vivo, as well as their adaptability to clinical settings, were investigated. Moreover, different configurations of 3D bioprinters are discussed. Finally, a roadmap for advancing wound dressings fabricated with 3D bioprinting is presented. Full article
(This article belongs to the Special Issue 3D Printing in Bio-Medical Applications)
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Other

Jump to: Research, Review

13 pages, 748 KiB  
Perspective
Three-Dimensional-Bioprinted Liver Chips and Challenges
by Sajjad Rahmani Dabbagh, Berin Ozdalgic, Nur Mustafaoglu and Savas Tasoglu
Appl. Sci. 2022, 12(10), 5029; https://doi.org/10.3390/app12105029 - 16 May 2022
Cited by 14 | Viewed by 3253
Abstract
Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries. Integrating 3D bioprinting with [...] Read more.
Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries. Integrating 3D bioprinting with microfluidic chips to fabricate organ-on-chip platforms for 3D liver cell cultures with continuous perfusion can offer a more physiologically relevant liver-mimetic platform for screening drugs and studying liver function. The development of organ-on-chip platforms may ultimately contribute to personalized medicine as well as body-on-chip technology that can test drug responses and organ–organ interactions on a single or linked chip model. Full article
(This article belongs to the Special Issue 3D Printing in Bio-Medical Applications)
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