Antitubercular Drugs: Synthesis, Mechanism and Application
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 9296
Special Issue Editors
Interests: tuberculosis drug discovery; antitubercular drug modes of action; biosynthesis of mycobacterial cell walls; structure, localization, and biological activities of actinobacterial glycolipids and glycans
Interests: biogenesis of mycobacterial cell envelope; functional characterization of mycobacterial genes; biochemical validation of drug targets; enzymatic assay development; screening of inhibitors; rational drug design
Special Issue Information
Dear Colleagues,
Tuberculosis, caused by Mycobacterium tuberculosis, remains a major public health problem worldwide and is responsible for nearly 1.5 million deaths annually. The increase of tuberculosis cases in recent years is related to an emergence of multidrug-resistant and extensive drug-resistant strains of M. tuberculosis and the AIDS pandemic. Although tuberculosis is a curable disease, its treatment requires multidrug and lengthy therapy associated with severe adverse effects, often leading to poor patient adherence. In the last two decades, great progress in tuberculosis drug discovery has been made while searching for the most suitable approach to lead generation. Although there are currently several drug candidates in the late stages of development and new drugs have been recently introduced into the antitubercular drug regimen, more compounds presenting a better efficacy, less-toxicity, and targeting different subpopulations of M. tuberculosis, which, simultaneously, are not affected by the existing resistance mechanisms, are certainly urgently needed. This is approached by both the discovery of new molecular scaffolds and reposing the old antitubercular drugs.
In this Special Issue, we invite submissions exploring tuberculosis drug discovery including, but not limited to, the synthesis, mode of action, and determining the efficacy of compounds. Reviews and original research papers are welcome.
Dr. Anna Grzegorzewicz
Dr. Zuzana Palčeková
Dr. Prithwiraj De
Guest Editors
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Keywords
- tuberculosis
- tuberculosis drug discovery
- drug synthesis
- hit and lead generation
- compounds screening
- minimal inhibitory concentration
- pharmacokinetic properties
- drug target
- mode of action
- intrinsic and acquired resistance
- persisters
- antitubercular drug regimen
- drug development pipeline
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