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Applied Sciences
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Current Topics in the Diagnostic Approach to Skin Diseases
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Current Topics in the Diagnostic Approach to Skin Diseases

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 9123

Special Issue Editors

Dr. Giuseppe Broggi

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia” Anatomic Pathology, University of Catania, 95123 Catania, Italy
Interests: neuropathology; surgical pathology; uveal melanoma; immunohistochemistry; dermatopathology; oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Rosario Caltabiano

E-Mail Website
Guest Editor
Department of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
Interests: immunohistochemistry; dermatopathology; neuropathology; uveal melanoma; head and neck pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dermatological research has always been focused on the identification of novel diagnostic tools capable of enhancing the diagnostic sensibility and accuracy of both neoplastic and inflammatory skin disease. In this regard, the introduction of dermoscopy has undoubtedly represented a “turning point” in dermatological diagnostic practice, allowing a rapid and non-invasive diagnosis of most cutaneous diseases. In spite of being aware that histologic examination still remains the “diagnostic gold standard” for skin tumors and inflammatory diseases, in the last decade, some novel diagnostic techniques have been introduced in dermatological practice, including in vivo reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT); these diagnostic tools allow a vertical and horizontal visualization of the skin with a resolution almost comparable to that of histopathology, improving the clinical diagnosis of most skin diseases.

This Special Issue is devoted to collecting original articles in which new relevant findings in both non-neoplastic and neoplastic skin diaseases are provided using the abovementioned diagnostic tools. Reviews and papers in which a correlation between dermoscopy/RCM/LC-OCT features and histopathology is provided are particulalry welcome. A limited number of relevant case reports will be also accepted.

Dr. Giuseppe Broggi
Prof. Dr. Rosario Caltabiano
Guest Editors

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Published Papers (4 papers)

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Editorial

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4 pages, 578 KiB  
Editorial
Current Topics in the Diagnostic Approach to Skin Diseases
by Giuseppe Broggi and Rosario Caltabiano
Appl. Sci. 2022, 12(15), 7576; https://doi.org/10.3390/app12157576 - 27 Jul 2022
Cited by 1 | Viewed by 1378
Abstract
The introduction of novel, non-invasive techniques capable of improving the diagnostic accuracy and sensibility of both inflammatory and neoplastic cutaneous diseases has always been one of the most practical objectives of dermatological research [...] Full article
(This article belongs to the Special Issue Current Topics in the Diagnostic Approach to Skin Diseases)
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Review

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7 pages, 5540 KiB  
Review
Horizontal Histopathology Correlation with In Vivo Reflectance Confocal Microscopy in Inflammatory Skin Diseases: A Review
by Giuseppe Broggi, Anna Elisa Verzì, Francesco Lacarrubba, Giuseppe Micali and Rosario Caltabiano
Appl. Sci. 2022, 12(4), 1930; https://doi.org/10.3390/app12041930 - 12 Feb 2022
Cited by 2 | Viewed by 2112
Abstract
Horizontal histopathological sections (HHSs) have been reported to show a strong correlation with images obtained via in vivo reflectance confocal microscopy (RCM), as both reflect the same horizontal plane of the skin. Although vertical histopathology remains the diagnostic gold standard for most neoplastic [...] Read more.
Horizontal histopathological sections (HHSs) have been reported to show a strong correlation with images obtained via in vivo reflectance confocal microscopy (RCM), as both reflect the same horizontal plane of the skin. Although vertical histopathology remains the diagnostic gold standard for most neoplastic and inflammatory skin diseases, HHSs represent a useful tool to validate the RCM features of some inflammatory disorders, including psoriasis, discoid lupus erythematosus, and eczema. The aim of the present review is to summarize the state of the art on the existing correlations between HHS and RCM in this field and to emphasize that RCM may represent a useful diagnostic tool to discriminate between diseases with similar clinical presentations. Full article
(This article belongs to the Special Issue Current Topics in the Diagnostic Approach to Skin Diseases)
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Other

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8 pages, 2720 KiB  
Case Report
Melanoma Metastases Arising at Unexpected Sites: Gallbladder and Uterus
by Giuseppe Broggi, Jessica Farina, Andrea Palicelli, Magda Zanelli, Gaetano Zizza, Francesca Sorci, Riccardo Morici and Rosario Caltabiano
Appl. Sci. 2023, 13(4), 2201; https://doi.org/10.3390/app13042201 - 8 Feb 2023
Cited by 1 | Viewed by 2280
Abstract
Although malignant melanoma (MM) most frequently tends to metastasize to the regional lymph nodes, liver, lung and brain, several unusual sites of metastasis have been described in the literature. Among these, the metastatic involvement of gallbladder or uterus represents an exceptional event, usually [...] Read more.
Although malignant melanoma (MM) most frequently tends to metastasize to the regional lymph nodes, liver, lung and brain, several unusual sites of metastasis have been described in the literature. Among these, the metastatic involvement of gallbladder or uterus represents an exceptional event, usually associated with diffuse metastatic disease or observed as an autopsy finding. In this paper, we present two unusual cases of isolated MM metastasis to these anatomic sites, arising in a 71-year-old man and a 54-year-old woman, for whom no information on previous malignancies was known at the time of the histological examination. The clinico-pathologic features are described, emphasizing that MM metastasis must be included in the differential diagnosis when dealing with patients with a previous diagnosis of MM and onset of a novel mass/lesion even at unusual sites. Full article
(This article belongs to the Special Issue Current Topics in the Diagnostic Approach to Skin Diseases)
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6 pages, 2211 KiB  
Case Report
Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis
by Jessica Farina, Giuseppe Broggi and Rosario Caltabiano
Appl. Sci. 2022, 12(6), 2977; https://doi.org/10.3390/app12062977 - 15 Mar 2022
Viewed by 2527
Abstract
The ossifying variant and the granular cell variant are rare subtypes of cutaneous fibrous histiocytoma (CFH), characterized by islands of mature metaplastic bone tissue rimmed by multinucleated osteoclast-like giant cells and by large-sized cells with granular cytoplasm and mildly hyperchromatic nuclei with inconspicuous [...] Read more.
The ossifying variant and the granular cell variant are rare subtypes of cutaneous fibrous histiocytoma (CFH), characterized by islands of mature metaplastic bone tissue rimmed by multinucleated osteoclast-like giant cells and by large-sized cells with granular cytoplasm and mildly hyperchromatic nuclei with inconspicuous nucleoli, respectively. We herein present two cases of these unusual CFH variants in a 37-year-old woman and in a 38-year-old man, respectively. The main differential diagnoses, including both benign and malignant lesions, are also discussed. Full article
(This article belongs to the Special Issue Current Topics in the Diagnostic Approach to Skin Diseases)
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