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Applied Sciences
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Recent Advances and Perspectives in Engineering Plant-Derived Metabolism
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Recent Advances and Perspectives in Engineering Plant-Derived Metabolism

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 3291

Special Issue Editors

Dr. Teresa Docimo

E-Mail Website
Guest Editor
Institute of Biosciences and Bioresources, IBBR-CNR, Via Universita' 133, 80055 Portici, Naples, Italy
Interests: plant specialized metabolites biosynthetic pathways, their regulation and evolution
Special Issues, Collections and Topics in MDPI journals
Dr. Vincenzo D’Amelia

E-Mail Website
Guest Editor
Institute of Biosciences and Bioresources, IBBR-CNR, Via Universita' 133, 80055 Portici, Naples, Italy
Interests: wild and cultivated solanaceae; plant derived drugs; genetic; genomic; plant specialized metabolites; metabolic engineering; plant breeding; plant functional biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plant plasticity is a plant's ability to adapt to and cope with a changing environment. This capability is mostly due to the biosynthesis of an incredible array of structurally complex, bioactive natural compounds that guarantee growth and survival. These molecules are also a source of food and feed, commodity products, and pharmaceuticals, therefore also facilitating human survival and wellbeing. Understanding the biosynthesis, regulation, and evolution of these biomolecules in plants is of great importance for increasing crop yield and quality, and enhancing the application of plant-derived compounds in several fields. This Special Issue aims to publish contributions on plant metabolism discovery, plant and microorganism engineering, and novel applications of plant compounds. All types of articles are welcome; we encourage the submission of original research reports, reviews, minireviews, and perspectives focusing on the following specific topics:

  • The biosynthesis of plant biomolecules in a changing environment.
  • The discovery of new specialized metabolites, the comprehension of their functions in plants, and their applications in human/animal health as well as novel uses in industry.
  • The biosynthesis and production of phytochemicals as a source of food/feed and for industrial uses.
  • New technologies for the prediction, elucidation, and engineering of plant metabolic pathways.
  • Novel approaches in synthetic biology for understanding and improving plant metabolism and physiology as well as powerful tools for the production and engineering of plant-derived metabolites.

Dr. Teresa Docimo
Dr. Vincenzo D’Amelia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic engineering
  • plant biotechnology
  • specialized metabolites
  • biosynthetic pathways
  • phytochemicals
  • human and animal health
  • novel commodities

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Published Papers (2 papers)

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Review

18 pages, 2091 KiB  
Review
The Spread of Invasive and Poisonous Plants: A Lesson from Alkaloids
by Rosa D’Alessandro, Rita Celano, Anna Lisa Piccinelli, Vincenzo D’Amelia and Teresa Docimo
Appl. Sci. 2024, 14(17), 8058; https://doi.org/10.3390/app14178058 - 9 Sep 2024
Viewed by 822
Abstract
Invasive plant species pose a significant threat to global biodiversity and ecosystems. Climate changes favor the spread of non-native plants, whether voluntary or accidentally introduced into a new environment, as these plants possess a greater ability to adapt to changing environments. The spreading [...] Read more.
Invasive plant species pose a significant threat to global biodiversity and ecosystems. Climate changes favor the spread of non-native plants, whether voluntary or accidentally introduced into a new environment, as these plants possess a greater ability to adapt to changing environments. The spreading of these alien species has a negative impact also on agro-ecosystems, on agricultural yields, and on the nutritional quality of food crops. The high metabolic plasticity of these plants helps them to adapt to new ecosystems, enabling them to succeed in competing with crops. In particular, many alien plants are producers of alkaloids. These molecules represent the main chemical defense to biotic stressors and also the major risk for human health. In this review, we focused on invasive plants producing tropane alkaloids (TAs) and pyrrolizidine alkaloids (PAs). We explored the potential role of these molecules in the fitness of invasive plants in the context of climate change and reviewed the knowledge regarding their biosynthesis steps and examined the mechanism of toxicity when accidentally ingested. Finally, we summarized the most efficient analytical and molecular methods to detect either alkaloid contamination or the presence of invasive plant contaminants, which are the source of these molecules, in food crops. Possible solutions and precautions to ensure food safety have been also proposed. Full article
(This article belongs to the Special Issue Recent Advances and Perspectives in Engineering Plant-Derived Metabolism)
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17 pages, 4233 KiB  
Review
Overcoming Metabolic Constraints in the MEP-Pathway Enrich Salvia sclarea Hairy Roots in Therapeutic Abietane Diterpenes
by Mariaevelina Alfieri, Alfredo Ambrosone, Mariacarmela Vaccaro, Nunziatina De Tommasi and Antonietta Leone
Appl. Sci. 2022, 12(14), 7116; https://doi.org/10.3390/app12147116 - 14 Jul 2022
Cited by 4 | Viewed by 1779
Abstract
Abietane diterpenoids (e.g., carnosic acid, aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol) synthesized in the roots of several Salvia species have proved to have promising biological activities, but their use on a large scale is limited by the very low content extracted from in vivo [...] Read more.
Abietane diterpenoids (e.g., carnosic acid, aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol) synthesized in the roots of several Salvia species have proved to have promising biological activities, but their use on a large scale is limited by the very low content extracted from in vivo roots. In this review, we summarized our efforts and the achieved results aimed at optimizing the synthesis of these diterpenes in Salvia sclarea hairy roots by either elicitation or by modifying the expression of genes encoding enzymes of the MEP-pathway, the biosynthetic route from which they derive. Stable S. sclarea hairy roots (HRs) were treated with methyl jasmonate or coronatine, or genetically engineered, by tuning the expression of genes controlling enzymatic rate-limiting steps (DXS, DXR, GGPPS, CPPS alone or in combination), by silencing of the Ent-CPPS gene, encoding an enzyme acting at gibberellin lateral competitive route or by coordinate up-regulation of biosynthetic genes mediated by transcription factors (WRKY and MYC2). Altogether, these different approaches successfully increased the amount of abietane diterpenes in S. sclarea HRs from to 2 to 30 times over the content found in the control HR line. Full article
(This article belongs to the Special Issue Recent Advances and Perspectives in Engineering Plant-Derived Metabolism)
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