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Optical Biosensors and Applications
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Optical Biosensors and Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (16 May 2020) | Viewed by 8036

Special Issue Editors

Prof. Dr. Miguel Holgado

E-Mail Website
Guest Editor
Group leader of the Optics, Photonics and Biophotonics group in the Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, 28223 Madrid, Spain
Interests: point of care systems based on optical detection; optoelectronics and biophotonics; optical readout systems; simulation and design of photonic structures as optical transducers
Special Issues, Collections and Topics in MDPI journals
Dr. Ana L. Hernández

E-Mail Website
Guest Editor
Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, 28223 Madrid, Spain
Interests: optical biosensors; optical readout systems; immunoassay development; organic surface modification for biofunctionalization of transducers; in-situ detection

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the use of optical biosensors in a wide range of applications and fields. Authors should demonstrate an advance in the field of optical biosensors, for example by providing new optical detection strategies as well as originality in the design and fabrication of novel optical transducers. In addition, submissions emphasizing their ease of use, their operational simplicity (in this sense contributions focused on label-free detection will be appreciated are but not required), their suitability for in-situ detection, their cheaper production (mass production) and multiplexing capacity are especially welcome. We encourage showing features and improvements addressed to boosting the commercialization of optical biosensors in different sectors of the market in upcoming years. 

Prof. Dr. Miguel Holgado
Dr. Ana L. Hernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical transducer
  • label-free
  • in-situ detection
  • multiplexing
  • point of care
  • optical readout system
  • photonic design
  • photonic structures
  • optical biological detection

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Published Papers (2 papers)

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Research

9 pages, 1149 KiB  
Article
Opto-Electronic Refractometric Sensor Based on Surface Plasmon Resonances and the Bolometric Effect
by Mahmoud H. Elshorbagy, Alexander Cuadrado, José Antonio Gómez-Pedrero and Javier Alda
Appl. Sci. 2020, 10(4), 1211; https://doi.org/10.3390/app10041211 - 11 Feb 2020
Cited by 5 | Viewed by 2335
Abstract
The bolometric effect allows us to electrically monitor spectral characteristics of plasmonic sensors; it provides a lower cost and simpler sample characterization compared with angular and spectral signal retrieval techniques. In our device, a monochromatic light source illuminates a spectrally selective plasmonic nanostructure. [...] Read more.
The bolometric effect allows us to electrically monitor spectral characteristics of plasmonic sensors; it provides a lower cost and simpler sample characterization compared with angular and spectral signal retrieval techniques. In our device, a monochromatic light source illuminates a spectrally selective plasmonic nanostructure. This arrangement is formed by a dielectric low-order diffraction grating that combines two materials with a high-contrast in the index of refraction. Light interacts with this structure and reaches a thin metallic layer, that is also exposed to the analyte. The narrow absorption generated by surface plasmon resonances hybridized with low-order grating modes, heats the metal layer where plasmons are excited. The temperature change caused by this absorption modifies the resistance of a metallic layer through the bolometric effect. Therefore, a refractometric change in the analyte varies the electric resistivity under resonant excitation. We monitor the change in resistance by an external electric circuit. This optoelectronic feature must be included in the definition of the sensitivity and figure of merit (FOM) parameters. Besides the competitive value of the FOM (around 400 RIU − 1 , where RIU means refractive index unit), the proposed system is fully based on opto-electronic measurements. The device is modeled, simulated and analyzed considering fabrication and experimental constrains. The proposed refractometer behaves linearly within a range centered around the index of refraction of aqueous media, n ≃ 1.33 , and can be applied to the sensing for research in bio-physics, biology, and environmental sciences. Full article
(This article belongs to the Special Issue Optical Biosensors and Applications)
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13 pages, 5798 KiB  
Article
A Low-Cost and Portable Smart Instrumentation for Detecting Colorectal Cancer Cells
by Mohammad Wajih Alam, Khan A. Wahid, Md. Fahmid Islam, Wendy Bernhard, Clarence R. Geyer and Franco J. Vizeacoumar
Appl. Sci. 2019, 9(17), 3510; https://doi.org/10.3390/app9173510 - 26 Aug 2019
Cited by 7 | Viewed by 5228
Abstract
Fluorescence imaging is a well-known method for monitoring fluorescence emitted from the subject of interest and provides important insights about cell dynamics and molecules in mammalian cells. Currently, many solutions exist for measuring fluorescence, but the application methods are complex and the costs [...] Read more.
Fluorescence imaging is a well-known method for monitoring fluorescence emitted from the subject of interest and provides important insights about cell dynamics and molecules in mammalian cells. Currently, many solutions exist for measuring fluorescence, but the application methods are complex and the costs are high. This paper describes the design and development of a low-cost, smart and portable fluorimeter for the detection of colorectal cancer cell expressing IRFP702. A flashlight is used as a light source, which emits light in the visible range and acts as an excitation source, while a photodiode is used as a detector. It also uses a longpass filter to only allow the wavelength of interest to pass from the cultured cell. It eliminates the need of both the dichroic mirror and excitation filter, which makes the developed device low cost, compact and portable as well as lightweight. The custom-built sample chamber is black in color to minimize interference and is printed with a 3D printer to accommodate the detector circuitry. An established colorectal cancer cell line (human colorectal carcinoma (HCT116)) was cultured in the laboratory environment. A near-infrared fluorescent protein IRFP702 was expressed in the colorectal cancer cells that were used to test the proof-of-concept. The fluorescent cancer cells were first tested with a commercial imaging system (Odyssey® CLx) and then with the developed prototype to validate the result in a preclinical setting. The developed fluorimeter is versatile as it can also be used to detect multiple types of cancer cells by simply replacing the filters based on the fluorophore. Full article
(This article belongs to the Special Issue Optical Biosensors and Applications)
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