Organs on a Chips
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 729
Special Issue Editors
Interests: MEMS/NEMS fabrication; lab on a chip; bio-micro fluidics; biosensors; liquid cell electron microscopy
Interests: organ on a chip; microfluidic systems; biosensors; CTCs/CTM diagnosis; single cell analysis
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Special Issue Information
Dear Colleagues,
We invite you to contribute to a Special Issue of the journal Applied Sciences, “Organs on a Chips”, which aims to present the microfluidic cell culture device that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ. It constitutes the subject matter of significant biomedical engineering, more precisely in bio-MEMS.
An organ-on-a-chip is a microfluidic cell culture device created with micro-fabrication process technology that contains continuously perfused chambers inhabited by living cells arranged to regenerate into tissue and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interface, physicochemical microenvironments and vascularization of the body. These devices produce the tissue and organ level functionality, which is not possible with conventional 2D or 3D culture systems. They also enable high-resolution, real-time imaging and in vitro analysis of biochemical, genetic, and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology, drug screening and disease etiology. In the context of drug discovery and pharmacokinetics, organ-on-a-chip is having upper hand and great potential against costlier, time taking conventional techniques. Other aspects and applications of organs on a chips, besides the example listed above, are also very welcome.
Dr. Pijus Kundu
Prof. Fan-Gang Tseng
Guest Editors
Manuscript Submission Information
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Keywords
- BioNEMS
- Nano/Micro fluidics
- Drug screening
- Tissue engineering
- Molecular detection
- Cancer markers
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