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Novel Nanomaterials and Sensing Platforms for Detection and Diagnosis of Coronaviruses

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 7027

Special Issue Editor

Prof. Dr. Manh-Huong Phan

E-Mail Website
Guest Editor
Department of Physics, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
Interests: nanomaterials; nanomagnetism; nanospintronics; nanobiosensors; biomedical applications of functional magnetic nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Corona virus 2019 (COVID-19) has killed more than two million people around the world, a number which continues to increase daily. This outbreak represents an unprecedented global public health challenge. To diagnose COVID-19 and limit its spreading, as well as to help doctors in clinical decision-making, an increasingly large number of medical devices and biosensors ultilizing functional nanomaterials and nanotechnology have recently been developed.

This Special Issue aims to feature the most significant advances in technological developments addressing COVID-19’s severe problems and associated viruses’. Original research papers and topical review articles are welcome. Short communications or perspective articles are also considered. It is anticipated that the Special Issue will stimulate further research in this rapidly expanding research field.

Prof. Manh-Huong Phan

Guest Editor


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Keywords

Areas of interest may include (but not limited to) the following: 

  • Biosensors
  • Respiratory monitors
  • Medical devices
  • Nanomaterials
  • Breathing
  • Respiratory diseases
  • Lung diseases 
  • Maskcovering effects

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Published Papers (3 papers)

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Research

9 pages, 1959 KiB  
Communication
A Disposable Soft Magnetic Ribbon Impedance-Based Sensor for Corrosion Monitoring
by Izabella Berman, Jagannath Devkota, Kee Young Hwang and Manh-Huong Phan
Appl. Sci. 2023, 13(10), 6011; https://doi.org/10.3390/app13106011 - 13 May 2023
Cited by 1 | Viewed by 1196
Abstract
We present a new approach for the real-time monitoring of chemical corrosion based on radio-frequency (RF) impedance technology and soft ferromagnetic ribbons. The impedance (Z) of a commercial METGLAS® 2714A ribbon was measured in real time for 5 μL of [...] Read more.
We present a new approach for the real-time monitoring of chemical corrosion based on radio-frequency (RF) impedance technology and soft ferromagnetic ribbons. The impedance (Z) of a commercial METGLAS® 2714A ribbon was measured in real time for 5 μL of drop-casted HNO3 of various concentrations. Variations in the concentration of the drop-casted acid were assessed by considering the difference in Z (η) with and without the acid treatment. We found a large and linear increase in η (from ~5 to ~35 mΩ) and a large linear decrease in measurement time (from ~240 to 70 s) with increases in acid concentration (from 0.9 to 7.4 Molar), which is promising for the development of disposable chemical sensors for the strength estimation of corrosive chemicals and for the monitoring of time-dependent chemical corrosion processes. Since the ribbon used is commercially available at a low cost and as the measurement system is quick and low power-consuming, the proposed sensor can be used as an easy, quick, and low-cost chemical probe in industry and for environmental hazard management purposes. Full article
(This article belongs to the Special Issue Novel Nanomaterials and Sensing Platforms for Detection and Diagnosis of Coronaviruses)
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15 pages, 1902 KiB  
Article
A Simple Approach for Counting CD4+ T Cells Based on a Combination of Magnetic Activated Cell Sorting and Automated Cell Counting Methods
by Ngoc Duc Vo, Anh Thi Van Nguyen, Hoi Thi Le, Nam Hoang Nguyen and Huong Thi Thu Pham
Appl. Sci. 2021, 11(21), 9786; https://doi.org/10.3390/app11219786 - 20 Oct 2021
Cited by 1 | Viewed by 2419
Abstract
Frequent tests for CD4+ T cell counting are important for the treatment of patients with immune deficiency; however, the routinely used fluorescence-activated cell-sorting (FACS) gold standard is costly and the equipment is only available in central hospitals. In this study, we developed [...] Read more.
Frequent tests for CD4+ T cell counting are important for the treatment of patients with immune deficiency; however, the routinely used fluorescence-activated cell-sorting (FACS) gold standard is costly and the equipment is only available in central hospitals. In this study, we developed an alternative simple approach (shortly named as the MACS-Countess system) for CD4+ T cell counting by coupling magnetic activated cell sorting (MACS) to separate CD4+ T cells from blood, followed by counting the separated cells using CountessTM, an automated cell-counting system. Using the cell counting protocol, 25 µL anti-CD4 conjugated magnetic nanoparticles (NP-CD4, BD Bioscience) were optimized for separating CD4+ T cells from 50 µL of blood in PBS using a DynamagTM-2 magnet, followed by the introduction of 10 µL separated cells into a CountessTM chamber slide for automated counting of CD4+ T cells. To evaluate the reliability of the developed method, 48 blood samples with CD4+ T cell concentrations ranging from 105 to 980 cells/µL were analyzed using both MACS-Countess and FACS. Compared with FACS, MACS-Countess had a mean bias of 3.5% with a limit of agreement (LoA) ranging from −36.4% to 43.3%, which is close to the reliability of the commercial product, PIMA analyzer (Alere), reported previously (mean bias 0.2%; LoA ranging from −42% to 42%, FACS as reference). Further, the MACS-Countess system requires very simple instruments, including only a magnet and an automated cell counter, which are affordable for almost every lab located in a limited resource region. Full article
(This article belongs to the Special Issue Novel Nanomaterials and Sensing Platforms for Detection and Diagnosis of Coronaviruses)
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10 pages, 1859 KiB  
Article
A Novel Magnetic Respiratory Sensor for Human Healthcare
by Kee Young Hwang, Valery Ortiz Jimenez, Baleeswaraiah Muchharla, Tatiana Eggers, Anh-Tuan Le, Vu Dinh Lam and Manh-Huong Phan
Appl. Sci. 2021, 11(8), 3585; https://doi.org/10.3390/app11083585 - 16 Apr 2021
Cited by 4 | Viewed by 2718
Abstract
Breathing is vital to life. Therefore, the real-time monitoring of a patient′s breathing pattern is crucial to respiratory rehabilitation therapies, such as magnetic resonance exams for respiratory-triggered imaging, chronic pulmonary disease treatment, and synchronized functional electrical stimulation. While numerous respiratory devices have been [...] Read more.
Breathing is vital to life. Therefore, the real-time monitoring of a patient′s breathing pattern is crucial to respiratory rehabilitation therapies, such as magnetic resonance exams for respiratory-triggered imaging, chronic pulmonary disease treatment, and synchronized functional electrical stimulation. While numerous respiratory devices have been developed, they are often in direct contact with a patient, which can yield limited data. In this study, we developed a novel, non-invasive, and contactless magnetic sensing platform that can precisely monitor a patient′s breathing, movement, or sleep patterns, thus providing efficient monitoring at a clinic or home. A magneto-LC resonance (MLCR) sensor converts the magnetic oscillations generated by a patient′s breathing into an impedance spectrum, which allows for a deep analysis of one′s breath variation to identify respiratory-related diseases like COVID-19. Owing to its ultrahigh sensitivity, the MLCR sensor yields a distinct breathing pattern for each patient tested. It also provides an accurate measure of the strength of a patient′s breath at multiple stages as well as anomalous variations in respiratory rate and amplitude. The sensor can thus be applied to detect symptoms of COVID-19 in a patient, due to shortness of breath or difficulty breathing, as well as track the disease′s progress in real time. Full article
(This article belongs to the Special Issue Novel Nanomaterials and Sensing Platforms for Detection and Diagnosis of Coronaviruses)
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