Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.3
2.5
Journals
Applied Sciences
Special Issues
Pharmaceutical Development and Drug Delivery
applsci-logo
Submit to Applied Sciences Review for Applied Sciences Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Pharmaceutical Development and Drug Delivery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 2228

Special Issue Editor

Prof. Dr. Gioconda Millotti

E-Mail Website
Guest Editor
Faculty of Natural Sciences, Juraj Dobrila University of Pula, Pula, Croatia
Interests: drug delivery; marine resources for biomedicine and drug delivery

Special Issue Information

Dear Colleagues,

We invite you to submit your research works for an upcoming Special Issue on “Pharmaceutical Development and Drug Delivery” in Applied Sciences.

As new medicines are being discovered, often through recombinant techniques or possessing of a peptidic nature, there is an urgent need to develop suitable delivery systems for these drugs. On the other hand, many drugs already on the market are not optimized for delivery; some are only administered intravenously because other routes would degrade the drug. This route is the least preferred by patients, as it causes pain and often requires a visit to a medical center, whereas oral drug delivery offers a more practical and appropriate method of delivery. Additionally, some drugs with enormous clinical potential suffer from low water solubility or poor permeability, necessitating a revision of their delivery systems to enhance their effectiveness. The development of prolonged drug delivery systems, which allow for once-daily administration, with the drug being released consistently over a long period, can significantly improve therapy. Advanced drug delivery systems ensure that medications reach their target sites efficiently, improving their efficacy and reducing side effects. They enable personalized treatments tailored to individual patients, increasing success rates and reducing adverse reactions. Drug delivery and pharmaceutical development focus on developing treatments for rare and chronic conditions, significantly improving patients' quality of life. Therefore, drug delivery and pharmaceutical development are crucial for advancing healthcare, ensuring effective and safe treatments, and addressing global health challenges.

This Special Issue aims to promote research in drug delivery and pharmaceutical development, focusing on the creation of novel delivery systems or the improvement of delivery methods for challenging drugs. We welcome both theoretical and experimental studies, as well as comprehensive reviews and survey papers.

Prof. Dr. Gioconda Millotti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutical development
  • enhanced drug delivery
  • advanced treatments
  • personalized medicine
  • addressing unmet medical treatments

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

24 pages, 2721 KiB  
Article
Simultaneous HPLC of Metformin, Glipizide and Gliclazide, and Metformin Uptake and Protection of HEI-OC1 from Hyperglycaemia
by Ahmed Gedawy, Hani Al-Salami and Crispin R. Dass
Appl. Sci. 2024, 14(22), 10469; https://doi.org/10.3390/app142210469 - 14 Nov 2024
Viewed by 974
Abstract
The antidiabetic drugs metformin, glipizide and gliclazide have been used for many years to control blood glucose levels. In recent years, they have gained importance in non-diabetic pharmacological purposes including cancer and hearing loss treatment. Co-administration of these therapeutics represents a challenge to [...] Read more.
The antidiabetic drugs metformin, glipizide and gliclazide have been used for many years to control blood glucose levels. In recent years, they have gained importance in non-diabetic pharmacological purposes including cancer and hearing loss treatment. Co-administration of these therapeutics represents a challenge to some clinicians seeking an efficient, sensitive and rapid analytical method to use in the pharmacokinetic studies and the therapeutic monitoring of these agents. This research outlines the development and validation of a new precise, robust, sensitive, selective and rapid ion-pairing reversed-phase HPLC method for the simultaneous determination of a ternary mixture of metformin, glipizide and gliclazide in the same isocratic chromatographic run within 5 min. The limits of detection were 59.22 ng/mL for metformin, 169.48 ng/mL for glipizide and 151.29 ng/mL for gliclazide. The method was applied in quantifying metformin uptake by the auditory cell line HEI-OC1, to gain an insight into the kinetics of this biguanide in the organ of Corti. Metformin exhibited a concentration-dependent uptake by HEI-OC1 cells up to 5 mM, after which, saturation of the uptake was noticed. When HEI-OC1 cells were subjected to diabetes-simulated conditions, metformin was able to mitigate the hyperglycaemic stress and revealed a protective role in this cell line. Full article
(This article belongs to the Special Issue Pharmaceutical Development and Drug Delivery)
►▼ Show Figures

Figure 1

18 pages, 4562 KiB  
Article
Immobilization of Levocetirizine on Mesoporous Silica for Antiallergenic Gel Formulation
by Klára Szentmihályi, Szilvia Klébert, Krisztina Móricz, Antal Balázs Szenes-Nagy, Zoltán May, Eszter Bódis, Miklós Mohai, László Trif, Mirella Mirankó, Tivadar Feczkó and Zoltán Károly
Appl. Sci. 2024, 14(20), 9605; https://doi.org/10.3390/app14209605 - 21 Oct 2024
Viewed by 874
Abstract
Levocetirizine dihydrochloride is an effective antiallergenic drug applied mostly orally; however, developing a topical formulation for localized treatment could be beneficial. To achieve this, a modified formulation technique is necessary to enhance bioavailability efficiency and minimize possible side effects. Therefore, levocetirizine particles were [...] Read more.
Levocetirizine dihydrochloride is an effective antiallergenic drug applied mostly orally; however, developing a topical formulation for localized treatment could be beneficial. To achieve this, a modified formulation technique is necessary to enhance bioavailability efficiency and minimize possible side effects. Therefore, levocetirizine particles were prepared by immobilization on mesoporous silica material. Both the dihydrochloride form and its free base of levocetirizine were fixed on a silica-type Syloid support. Immobilization of the active ingredient levocetirizine in a free base form on a Syloid support by mixing in a dichloromethane solution provides better surface coverage (65.5%) than immobilization in the dihydrochloride form in water or methanol (24.5% for both). The successful binding of levocetirizine was confirmed by X-ray photoelectron spectroscopy and infrared measurements. The active ingredient in the form of hydrochloride is more likely to be in the pores, while the free base is bound to the surface in larger quantities. The time-dependent levocetirizine release showed that the liberation of the active ingredient from the Syloid is slower than the dissolution of the starting active ingredient itself, so it may be suitable for exerting a more reliable and prolonged local effect. A gel containing a Syloid-fixed levocetirizine free base was tested in vivo in a croton oil-induced ear edema mouse model. When compared to a reference gel, the half-dose formulation containing levocetirizine free base demonstrated a similar efficacy to Fenistil gel, indicating that the new formulation may offer superior effectiveness at lower doses. Full article
(This article belongs to the Special Issue Pharmaceutical Development and Drug Delivery)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop