Advances in Improving Drug Dissolution, Solubility, and Bioavailability
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 6598
Special Issue Editor
Interests: pharmacy; physical pharmacy; physical chemistry; biomaterials; environmental chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, many studies have focused on how to improve drug delivery and bioavailability. The increased interest in this field is associated with the development of various disciplines such as nanotechnology, crystal engineering, materials engineering, polymer science, and even 3D printing technology. Poor bioavailability of pharmaceuticals is often related to their low solubility or low dissolution rate. Overcoming this problem requires the introduction of significant structural changes in pharmaceutically active ingredients, such as amorphization or the addition of excipients acting as solubilizers (multicomponent crystals, pharmaceutical eutectics, etc.). Another important problem affecting poor drug bioavailability is their low cell membrane permeability. In this case, various types of drug carriers can be helpful, including those prepared using nanotechnological techniques. In addition, in many cases it is necessary to achieve controlled drug release, which involves reaching its optimal bioavailability. It is worth noting that theoretical methods such as QSPR, molecular dynamics, and quantum-chemical computations have been successfully used to improve drug delivery. Many research projects in this field consist in virtual screenings such as in silico modeling of co-crystallization and of interactions in multicomponent systems.
The purpose of the Special Issue “Advances in Improving Drug Dissolution, Solubility, and Bioavailability” is to present the latest research on the improvement of drug bioavailability, including all dosage forms and the results of modifying important drug physicochemical properties such as solubility, dissolution rate, and cell membrane permeability.
Dr. Maciej Przybyłek
Guest Editor
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Keywords
- Bioavailability
- Drug Delivery
- Solubility
- Dissolution Rate
- Permeability
- ADME
- Pharmacokinetics
- Biopharmaceutics Classification System
- Cocrystals
- Pharmaceutical Eutectics
- Amorphous Drugs
- Co-Amorphous Drug Formulations
- Nutraceuticals
- Nanomaterials
- Cyclodextrins
- Macromolecular Carriers
- Micronization
- Liquid Dosage Forms
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