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New Functional Food Ingredients to Improve Health

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 6235

Special Issue Editors


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Guest Editor
Food Processing Research Group, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
Interests: biotechnology; functional foods; drug delivery; bioactive peptides; probiotics; obesity

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Guest Editor
Food Processing Research Group, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
Interests: functional foods; bioactives; active and smart food packaging; oleogels; by-products valorization; food nanostructures; food texture; probiotics; gut-on-chip microfluidics; cell-based meat
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Food Processing Research Group, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
Interests: 3D food printing; active and smart food packaging; microbial enzymes; bioactives; functional foods; microalgae; food nanostructures; cell-based meat; enzyme technology; protein purification

Special Issue Information

Dear Colleagues,

Food is no longer “just food”. Consumers increasingly demand foods which reduce or prevent food-related diseases, and one can now find anti-cholesterol, anti-hypertensive, and probiotic-containing foods and beverages already in the market. Further, functional foods improving physical, mental, or emotional wellbeing are foreseen by consumers and scientists, since the interplay between the diet and the microbiota–gut–brain axis is known to have a pivotal role in the metabolic, immune, and nervous systems.

The recovery of natural compounds bearing promising bioactivities is still the focus of many research efforts, including their purification from food wastes and by-products, and the prospect of new bioactivities from natural sources such as plants, animals, microorganisms and algae, among others. The implementation of these bioactives into functional foods/nutraceuticals is still limited by two major challenges: (i) stabilization of the bioactives and (ii) controlled release at the target site. The encapsulation of these bioactives can protect them from the food matrix and harsh gastrointestinal conditions, while also providing a selective release at different sites of the gastrointestinal tract by selecting adequate encapsulating materials.

The development of new functional food ingredients demands a comprehensive study of their production and characterization, their stabilization using food-grade polymers, and the testing of their functionality and bioaccesibility/bioavailability using in vitro tools or organ-on-a-chip technologies.


Dr. Isabel Rodríguez Amado
Prof. Dr. Lorenzo M. Pastrana
Dr. Pablo Fuciños
Guest Editors

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Keywords

  • bioactive compounds
  • antioxidant
  • antidiabetic
  • probiotics
  • satiety
  • gut-brain axis
  • encapsulation
  • bioavailability
  • in vitro testing
  • stability

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Published Papers (2 papers)

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Research

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13 pages, 5811 KiB  
Article
Anti-Inflammatory Properties of MSF, a Lactiplantibacillus plantarum K8 Lysate Fermented with Filipendula glaberrima Extract
by Kyeong-Hun Choi, Jonghyo Hong, Ki-Young Kim, Hangeun Kim, Sanghyun Lee, Yunji Lee and Dae-Kyun Chung
Appl. Sci. 2022, 12(5), 2602; https://doi.org/10.3390/app12052602 - 2 Mar 2022
Cited by 3 | Viewed by 2706
Abstract
Inflammation plays an important role in the pathogenesis of metabolic syndrome, which increases the risk of heart disease, stroke, type 2 diabetes, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), and obesity. Here, we produced potent anti-inflammatory probiotic lysates, termed MSF (miracle synergistic material made [...] Read more.
Inflammation plays an important role in the pathogenesis of metabolic syndrome, which increases the risk of heart disease, stroke, type 2 diabetes, atherosclerosis, non-alcoholic fatty liver disease (NAFLD), and obesity. Here, we produced potent anti-inflammatory probiotic lysates, termed MSF (miracle synergistic material made using Filipendula glaberrima), using fermentation with F. glaberrima extracts. MSF inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production through down-regulation of c-Jun N-terminal kinase (JNK) signaling. MSF-induced tolerance for TNF-α was mediated by induction of TNF alpha-induced protein 3 (TNFAIP3 or A20). On the other hand, MSF showed a synergistic effect on interleukin (IL)-1β production in LPS-stimulated human monocytic leukemia cell line (THP-1 cells). This synergistic effect of the combination of MSF and LPS might be mediated by nuclear factor kappa B (NF-kB) signaling. The inhibitory effect of TNF-α and synergistic effect of IL-1β due to combining MSF and LPS were significantly higher than those of a combination of L. plantarum K8 lysates and LPS. The MSF and LPS combination showed reduced mouse mortality compared to a combination of L. plantarum K8 lysates and LPS, which correlated with decreased levels of cytokines, hepatic alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in the blood and liver. These results show that probiotic lysates fermented with natural extracts such as F. glaberrima have higher anti-inflammatory efficacy than conventional probiotic lysates or natural extracts. Full article
(This article belongs to the Special Issue New Functional Food Ingredients to Improve Health)
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Review

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26 pages, 1139 KiB  
Review
Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes
by Marisol Dias, Marina Romaní-Pérez, Aloia Romaní, Aimara de la Cruz, Lorenzo Pastrana, Pablo Fuciños and Isabel R. Amado
Appl. Sci. 2022, 12(18), 9271; https://doi.org/10.3390/app12189271 - 15 Sep 2022
Cited by 4 | Viewed by 2663
Abstract
Background: Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. Materials and methods: We have performed a literature review on the [...] Read more.
Background: Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. Materials and methods: We have performed a literature review on the main topics related to the application of phenolic compounds as functional food ingredients. This includes extraction and purification from vegetable sources and agro-industrial by-products, encapsulation to improve their solubility and bioavailability, and preclinical and clinical evidence linking these compounds with anti-diabetic activity. Objectives: (1) provide an understanding of the role of phenolic compounds on diabetes; (2) identify green technologies for phenolic compounds extraction from agri-food by-products following a biorefinery scheme; (3) underline the relevance of encapsulation techniques using nanotechnology to improve their bioavailability; (4) discuss the therapeutic efficacy of polyphenols. Results: This review compiles recent relevant research on phenolic compounds extraction from renewable resources, their purification from agri-food by-products, and encapsulation strategies using eco-friendly processes. It also highlights the preclinical and clinical evidence on phenolic compounds’ antidiabetic activity, giving insight into their mechanisms of action. Conclusions: This review explores the latest advances in polyphenols and how their benefits in glucose homeostasis can be applied toward improving the health of patients with diabetes and related conditions. Full article
(This article belongs to the Special Issue New Functional Food Ingredients to Improve Health)
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