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New Synthesis Strategies of Nanoparticles and Applications in Drug Delivery

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (28 February 2020) | Viewed by 9224

Special Issue Editors


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Guest Editor
Department of Biomedical and Biotechnological Sciences BIOMETEC, University of Catania, Catania, Italy
Interests: antibacterial activity; antimycoplasma activity; antiviral activity; natural extract; essential oils; coronavirus; probiotics; drug delivery development
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy
Interests: drug delivery systems; solid lipid nanoparticles; drug carriers; antibiotics; antimicrobial activity; antiviral activity; prebiotics; probiotics; postbiotics; gut microbiota; gut-brain axis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

After two to three decades where various hypotheses and strategies were proposed and tested, most of which failed when facing industrial scale-up or real clinical usefulness, applications of technological approaches and platforms using nano-scaled systems (nanomedicine) are progressively assuming value in medicine as well as in clinical practice. We are now in a time where nanotechnology is mature enough to efficiently address its potentiality towards patients’ care, which is called “translational nanomedicine”. In this regard, proposals of new biomaterials and production methods from researchers are increasingly tailored to industrial feasibility and, above all, clinical needs. For many years, cancer therapy has been gaining interest in drug delivery research, and today, other fields have become more and more attractive for nanotechnological tools, such as protein and peptide delivery, antimicrobial delivery, vaccine delivery, gene therapy, rare diseases, and, even more recently, medical device industry.

This Special Issue is aimed at collecting relevant and high-level experimental studies on the new biomaterials and matrices that are able to produce nanosystems and nanodevices for the controlled release and targeting of drugs and other bioactive compounds. Moreover, particular attention will be devoted to “green nanomedicine”, as well as to bio-inspired, bioengineered, and biomimetic drug delivery carriers (such as virosomes, biohybrid drug delivery systems, bioengineered bacterial outer membrane vesicles, etc.). Finally, research incorporating preclinical or clinical results will certainly be of great interest.  

Assoc. Prof. Dr. Pio Maria Furneri
Dr. Virginia Fuochi
Prof. Rosario Pignatello
Guest Editors

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Keywords

  • drug targeting
  • antibacterial drugs
  • gene delivery
  • antiviral drugs
  • anticancer agents
  • nanomedicine
  • biomimetic drug delivery carriers
  • green nanomedicine
  • bioengineered bacterial outer membrane vesicles
  • virosomes

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Published Papers (1 paper)

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Review

25 pages, 1024 KiB  
Review
Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine
by Maryam Muhammad Mailafiya, Kabeer Abubakar, Abubakar Danmaigoro, Samaila Musa Chiroma, Ezamin Bin Abdul Rahim, Mohamad Aris Mohd Moklas and Zuki Abu Bakar Zakaria
Appl. Sci. 2019, 9(14), 2897; https://doi.org/10.3390/app9142897 - 19 Jul 2019
Cited by 49 | Viewed by 8708
Abstract
Cockle shell is an external covering of small, salt water edible clams (Anadara granosa) that dwells in coastal area. This abundant biomaterial is hard, cheap and readily available with high content of calcium carbonate in aragonite polymorphic form. At present, cockle [...] Read more.
Cockle shell is an external covering of small, salt water edible clams (Anadara granosa) that dwells in coastal area. This abundant biomaterial is hard, cheap and readily available with high content of calcium carbonate in aragonite polymorphic form. At present, cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NPs) with dual applications has remarkably drawn significant attention of researchers in nanotechnology as a nanocarrier for delivery of different categories of drugs and as bone scaffold due to its beneficial potentials such as biocompatibility, osteoconductivity, pH sensitivity, slow biodegradation, hydrophilic nature and a wide safety margin. In addition, CSCaCO3NP possesses structural porosity, a large surface area and functional group endings for electrostatic ion bonds with high loading capacity. Thus, it maintains great potential in the drug delivery system and a large number of biomedical utilisations. The pioneering researchers adopted a non-hazardous top-down method for the synthesis of CSCaCO3NP with subsequent improvements that led to the better spherical diameter size obtained recently which is suitable for drug delivery. The method is therefore a simple, low cost and environmentally friendly, which involves little procedural steps without stringent temperature management and expensive hazardous chemicals or any carbonation methods. This paper presents a review on a few different types of nanoparticles with emphasis on the versatile most recent advancements and achievements on the synthesis and developments of CSCaCO3NP aragonite with its applications as a nanocarrier for drug delivery in nanomedicine. Full article
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