Biomaterials and Technology for Skin Wound Healing

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2002

Special Issue Editor


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Guest Editor
Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Aachen, Germany
Interests: tissue engineering of vascularized tissue replacement; lymphangiogenesis and bioartificial vascularized lymphoid tissue equivalents in the arteriovenous loop model; limb reconstruction, lymphedema, lipedema, enzymatic debridement, and skin substitutes for mixed-grade burns

Special Issue Information

Dear Colleagues,

We are planning a Special Issue entitled “Biomaterials and Technology for Skin Wound Healing”.  

Thermal injuries constitute one the most common causes of trauma and are associated with significant physical and psychological consequences in both children and adults alike. In addition, the high case load and complexity of thermal injuries result in a significant burden on our respective health care systems. The high demands for specialized quality of care emphasize the need for selective and individualized treatment algorithms in these patients.

Over the last few years, the development of enzymatic debridement and novel skin substitute materials has evolved the treatment of burn injuries. Multiple synthetic wound dressings have been established in surgical therapy thanks to their properties of infection prevention and pain reduction, as well as fewer wound dressing changes. Decellularized fish skin has been shown to have supportive properties in the wound healing of chronic wounds and appears promising for the treatment of deep partial-thickness burn wounds. As such advances in synthetic- and biomaterials allow the implementation of more personalized treatment concepts, they further the advances in the adequate treatment of burn trauma.

This Special Issue therefore seeks a more detailed understanding of biomaterials and technology for the skin wound healing of burns and chronic wounds.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Advanced experimental techniques for wound-healing-supporting biomaterials;
  • Experimental investigations into the interrelationship between the biomaterial behaviors of tissue;
  • Molecular and cellular biomechanics of biomaterials and technology for wound healing;
  • Tissue engineering of skin substitutes;
  • Applications of novel skin substitute materials in different clinical settings;
  • Validation and comparison of synthetic wound dressings or decellularized skin substitutes.

Dr. Anja Miriam Boos
Guest Editor

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Keywords

  • synthetic wound dressings
  • decellularized skin substitutes
  • personalized therapy concepts
  • wound healing
  • burns

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Published Papers (2 papers)

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Research

28 pages, 21118 KiB  
Article
Galectin-3/Gelatin Electrospun Scaffolds Modulate Collagen Synthesis in Skin Healing but Do Not Improve Wound Closure Kinetics
by Karrington A. McLeod, Madeleine Di Gregorio, Dylan Tinney, Justin Carmichael, David Zuanazzi, Walter L. Siqueira, Amin Rizkalla and Douglas W. Hamilton
Bioengineering 2024, 11(10), 960; https://doi.org/10.3390/bioengineering11100960 - 25 Sep 2024
Viewed by 847
Abstract
Chronic wounds remain trapped in a pro-inflammatory state, with strategies targeted at inducing re-epithelialization and the proliferative phase of healing desirable. As a member of the lectin family, galectin-3 is implicated in the regulation of macrophage phenotype and epithelial migration. We investigated if [...] Read more.
Chronic wounds remain trapped in a pro-inflammatory state, with strategies targeted at inducing re-epithelialization and the proliferative phase of healing desirable. As a member of the lectin family, galectin-3 is implicated in the regulation of macrophage phenotype and epithelial migration. We investigated if local delivery of galectin-3 enhanced skin healing in a full-thickness excisional C57BL/6 mouse model. An electrospun gelatin scaffold loaded with galectin-3 was developed and compared to topical delivery of galectin-3. Electrospun gelatin/galectin-3 scaffolds had an average fiber diameter of 200 nm, with 83% scaffold porosity approximately and an average pore diameter of 1.15 μm. The developed scaffolds supported dermal fibroblast adhesion, matrix deposition, and proliferation in vitro. In vivo treatment of 6 mm full-thickness excisional wounds with gelatin/galectin-3 scaffolds did not influence wound closure, re-epithelialization, or macrophage phenotypes, but increased collagen synthesis. In comparison, topical delivery of galectin-3 [6.7 µg/mL] significantly increased arginase-I cell density at day 7 versus untreated and gelatin/galectin-3 scaffolds (p < 0.05). A preliminary assessment of increasing the concentration of topical galectin-3 demonstrated that at day 7, galectin-3 [12.5 µg/mL] significantly increased both epithelial migration and collagen content in a concentration-dependent manner. In conclusion, local delivery of galectin 3 shows potential efficacy in modulating skin healing in a concentration-dependent manner. Full article
(This article belongs to the Special Issue Biomaterials and Technology for Skin Wound Healing)
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19 pages, 9202 KiB  
Article
The Potential of Composite Cements for Wound Healing in Rats
by Alina Ioana Ardelean, Sorin Marian Marza, Madalina Florina Dragomir, Andrada Negoescu, Codruta Sarosi, Cristiana Stefania Novac, Cosmin Pestean, Marioara Moldovan and Liviu Oana
Bioengineering 2024, 11(8), 837; https://doi.org/10.3390/bioengineering11080837 - 16 Aug 2024
Cited by 1 | Viewed by 886
Abstract
Recent developments in biomaterials have resulted in the creation of cement composites with potential wound treatment properties, even though they are currently mainly employed for bone regeneration. Their ability to improve skin restoration after surgery is worth noting. The main purpose of this [...] Read more.
Recent developments in biomaterials have resulted in the creation of cement composites with potential wound treatment properties, even though they are currently mainly employed for bone regeneration. Their ability to improve skin restoration after surgery is worth noting. The main purpose of this research is to evaluate the ability of composite cement to promote wound healing in a rat experimental model. Full-thickness 5 mm skin defects were created, and the biomaterials were applied as wound dressings. The hybrid light-cured cement composites possess an organic matrix (Bis-GMA, TEGDMA, UDMA, and HEMA) and an inorganic phase (bioglasses, silica, and hydroxyapatite). The organic phase also contains γ-methacryloxypropyl-trimethoxysilane, which is produced by distributing bioactive silanized inorganic filler particles. The repair of the defect is assessed using a selection of macroscopic and microscopic protocols, including wound closure rate, histopathological analysis, cytotoxicity, and biocompatibility. Both composites exerted a favorable influence on cells, although the C1 product demonstrated a more extensive healing mechanism. Histological examination of the kidney and liver tissues revealed no evidence of toxicity. There were no notable negative outcomes in the treated groups, demonstrating the biocompatibility and efficacy of these bioproducts. By day 15, the skin of both groups had healed completely. This research introduces a pioneering strategy by utilizing composite cements, traditionally used in dentistry, in the context of skin wound healing. Full article
(This article belongs to the Special Issue Biomaterials and Technology for Skin Wound Healing)
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