3D Bioprinting in Bioengineering

A topical collection in Bioengineering (ISSN 2306-5354). This collection belongs to the section "Nanobiotechnology and Biofabrication".

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Editor


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Collection Editor
Director, Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nuernberg (FAU), 91054 Erlangen, Germany
Interests: microsurgery; flap surgery; hand surgery; reconstructive surgery; tissue engineering; biofabrication
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Topical Collection Information

Dear Colleagues,

Recent advances and technical developments have increased the availability of 3D bio-printing among the scientific community, hence making it popular for numerous biomedical applications. While pre-bioprinting (essentially a 3D modelling step) may include scaffold generation with various resin or filament fibers, the usage of biological material, alone or in combination with cells, deserves the further development of appropriate functional bioinks. These combinations comprise a whole new field within bioengineering that aims to further develop and optimize the techniques of 3D bioprinting itself, as well as to generate and perfect bioinks based on specifically designed cell-laden hydrogels. The vision is to enable the simultaneous processing of biomaterials and cells to 3D-print structures of sufficient biochemical and structural complexity that resemble and/or feature tissue properties. Given its enormous possibilities, 3D bioprinting has the power to become a disruptive technique in biomedical engineering, and is thus attracting massive interest from researchers from different disciplines worldwide.

We cordially invite all colleagues and researchers in this fascinating field to contribute to the present Topical Collection, and we look forward to receiving your contributions.

Prof. Dr. Raymund E. Horch
Collection Editor

Manuscript Submission Information

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Keywords

  • biomimicry and printing of hierarchical or gradient structures for TE
  • features and properties of bioinks
  • biomaterials for 3D printing
  • translational bioengineering and applications
  • biomechatronics
  • biomimetics
  • biomedical imaging and medical information systems
  • biological implants and regenerative medicine
  • biomodeling and simulation
  • vascularization of bioprinted items
  • bioprinting and cancer research models
  • cell–cell interactions for bioprinting
  • 4D bioprinting
  • functional bioinks
  • new printing approaches
  • merging different printing approaches

Published Papers (1 paper)

2024

13 pages, 4165 KiB  
Article
Three-Dimensional Printed Customized Scaffolds Covered with Decellularized Bone Extracellular Matrix for Open-Wedge High-Tibial Osteotomy
by Geunseon Ahn, Jun-Young Kim, Jin-Hyung Shim, Sang-Hyun An, Junsik Kim, Changhwan Kim, In-Gyu Lee, Jung-Min Shin and Byunghoon Lee
Bioengineering 2024, 11(11), 1129; https://doi.org/10.3390/bioengineering11111129 - 8 Nov 2024
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Abstract
Void fillers are required for osseous gaps generated after orthopedic procedures as medial open-wedge high-tibial osteotomy (MOWHTO) to provide sufficient structural support and a rapid osteosynthesis. We developed a novel three-dimensional (3D) printing-based platform technology using the customized 3D scaffolds covered with polycaprolactone [...] Read more.
Void fillers are required for osseous gaps generated after orthopedic procedures as medial open-wedge high-tibial osteotomy (MOWHTO) to provide sufficient structural support and a rapid osteosynthesis. We developed a novel three-dimensional (3D) printing-based platform technology using the customized 3D scaffolds covered with polycaprolactone (PCL)/β-tri-calcium phosphates (β-TCP)/bone decellularized extracellular matrix (dECM) for use as bone substitute scaffold, which can be effectively exploited to estimate the calculated correction angle with preoperative simulations. PCL/β-TCP/bone dECM scaffolds demonstrated significantly higher cell contain levels in cell seeding efficiency, excellent proliferation capacity, and promotion of early osteogenic differentiation compared with PCL/β-TCP scaffolds. The scaffolds promoted bone mineralization at the early time points of an in vivo study (8 weeks) and exhibited biodegradable properties (38% for 16 weeks). The correction angle measured after osteotomy using 3D printed scaffolds was estimated with high accuracy with low errors (10.3° ± 0.9°) and was not significantly different even in the presence of lateral cortical hinge fractures. The customized 3D scaffold enriched with PCL/β-TCP/bone dECM yielded excellent cell seeding efficiency, proliferation capacity, early osteogenic differentiation, and bone mineralization outcomes. It is expected to solve the disadvantages related to bone union in MOWHTO and to replace autografts in the future. Full article
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