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Plastic and Reconstructive Surgery in Personalized Medicine: 2nd Edition
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Plastic and Reconstructive Surgery in Personalized Medicine: 2nd Edition

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 10 July 2025 | Viewed by 5037

Special Issue Editors

Prof. Dr. Raymund E. Horch

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Guest Editor
Director, Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nuernberg (FAU), 91054 Erlangen, Germany
Interests: microsurgery; flap surgery; hand surgery; reconstructive surgery; tissue engineering; biofabrication
Special Issues, Collections and Topics in MDPI journals
Dr. Aijia Cai

E-Mail Website
Guest Editor
Department of Plastic and Hand Surgery, Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany
Interests: microsurgery; flap surgery; hand surgery; reconstructive surgery; tissue engineering; biofabrication
Prof. Dr. Andreas Arkudas

E-Mail Website
Guest Editor
Department of Plastic and Hand Surgery, Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany
Interests: microsurgery; flap surgery; hand surgery; reconstructive surgery; tissue engineering; biofabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The tremendous success of the Special Issue “Plastic and Reconstructive Surgery in Personalized Medicine” and multiple requests to continue this series revealed to us the need for further research in this new field of reconstructive surgery and inspired us to continue the series.

The personalization of medicine has now become a necessity in many fields of diagnostics and therapy. Therefore, it is obvious that surgical modalities also need to become increasingly customized to individual patient’s needs and to optimal individualized forms of care. Despite the broad spectrum of indications and the ever-growing reconstructive possibilities, it is key to modern developments that all the various reconstructive techniques, including split-skin transplantation and local and free flaps, need to be personalized in every case.

By means of microsurgery and perforator flaps, every reconstructive concern ought to be addressed today via individually personalized custom-tailored techniques. Flaps can comprise different tissues and can be designed using novel imaging technologies in order to enhance the safety of the procedures and to retain the form and function of the reconstructed area in accordance with the donor site morbidity. The advent of biotechnology with tissue engineering and biofabrication has fostered the development of innovative technologies in plastic and reconstructive surgery, and may well become another tool with which to personalize reconstructive approaches.

This Special Issue of the Journal of Personalized Medicine Part II focuses on the following topics:

  • Individualized microsurgery and reconstructive surgery;
  • Perioperative flap imaging;
  • Customized perforator flaps;
  • Monitoring flap perfusion;
  • Tailored tissue engineering for reconstruction;
  • Biofabrication applications in personalized plastic and reconstructive surgery.

Please submit your article with your latest achievements in these fields to the journal. We look forward to receiving your contributions to this journal.

Prof. Dr. Raymund E. Horch
Dr. Aijia Cai
Prof. Dr. Andreas Arkudas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microsurgery
  • reconstruction
  • flap imaging
  • perforator flaps
  • diagnsotic tools
  • perioeprative imaging biofabrication in plastic surgery

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Published Papers (3 papers)

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12 pages, 1916 KiB  
Article
Single-Stage Peninsular-Shaped Lateral Tongue Flap for Personalized Reconstruction of Various Small- to Moderate-Sized Intraoral Defects: A Retrospective Case Series with Tongue Function Evaluation Using the Functional Intraoral Glasgow Scale
by Wonseok Cho, Eun-A Jang and Kyu-Nam Kim
J. Pers. Med. 2023, 13(12), 1637; https://doi.org/10.3390/jpm13121637 - 24 Nov 2023
Viewed by 1422
Abstract
Herein, we present our experience using a single-stage peninsular-shaped lateral tongue flap (pLTF) to cover various intraoral defects and confirm the versatile utility and effective application of pLTF in intraoral defect reconstruction. This study included eight cases (six males and two females; average [...] Read more.
Herein, we present our experience using a single-stage peninsular-shaped lateral tongue flap (pLTF) to cover various intraoral defects and confirm the versatile utility and effective application of pLTF in intraoral defect reconstruction. This study included eight cases (six males and two females; average age 60.3 ± 16.9 years) of intraoral defect reconstruction performed by a single surgeon between August 2020 and May 2023 using the single-stage pLTF technique. Electronic medical records and photographs of the patients were collected and analyzed. The functional intraoral Glasgow scale (FIGS) was used to evaluate preoperative and postoperative tongue function. Defect sizes ranged from 3 cm × 3 cm to 4 cm × 6 cm. Notably, all defects were successfully covered with pLTFs, and the flap sizes ranged between 3 cm × 4.5 cm and 4.5 cm × 7.5 cm. The flaps completely survived without any postoperative complications. At follow-up (average, 9.87 ± 2.74 months), no patient had tumor recurrence or significant tongue functional deficits. The mean preoperative and postoperative FIGS were 14.75 ± 0.46 and 14.00 ± 0.92, respectively (p = 0.059). Thus, the single-stage pLTF technique is a good reconstructive modality for various small to moderate intraoral defect coverage in selected cases for personalized intraoral reconstruction. Full article
(This article belongs to the Special Issue Plastic and Reconstructive Surgery in Personalized Medicine: 2nd Edition)
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14 pages, 6950 KiB  
Article
The Influence of Different Irradiation Regimens on Inflammation and Vascularization in a Random-Pattern Flap Model
by Wibke Müller-Seubert, Patrick Ostermaier, Raymund E. Horch, Luitpold Distel, Benjamin Frey, Ramona Erber and Andreas Arkudas
J. Pers. Med. 2023, 13(10), 1514; https://doi.org/10.3390/jpm13101514 - 21 Oct 2023
Cited by 1 | Viewed by 1248
Abstract
Background: Irradiation plays an important role in the oncological treatment of various tumor entities. The aim of the study was to investigate the influence of different irradiation regimens on random-pattern flaps at the molecular and histopathological levels. Methods: Twenty-five rats underwent harvesting of [...] Read more.
Background: Irradiation plays an important role in the oncological treatment of various tumor entities. The aim of the study was to investigate the influence of different irradiation regimens on random-pattern flaps at the molecular and histopathological levels. Methods: Twenty-five rats underwent harvesting of bilateral random-pattern fasciocutaneous flaps. The right flaps received irradiation, while the left flaps served as non-irradiated intraindividual controls. Five rats served as a non-irradiated control group. Four different irradiation regimens with give rats each were tested: 20 Gy postoperatively, 3 × 12 Gy postoperatively, 20 Gy preoperatively, and 3 × 12 Gy preoperatively. Two weeks after surgery, HE staining and immunohistochemical staining for CD68 and ERG, as well as PCR analysis to detect Interleukin 6, HIF-1α, and VEGF, were performed. Results: A postoperative cumulative higher dose of irradiation appeared to result in an increase in necrosis, especially in the superficial layers of the flap compared to preoperative or single-stage irradiation. In addition, we observed increased expression of VEGF and HIF-1α in all irradiation groups. Conclusion: Even though no statistically significant differences were found between the different groups, there was a tendency for fractional postoperative irradiation with a higher total dose to have a more harmful effect compared to preoperative or single-dose irradiation. Full article
(This article belongs to the Special Issue Plastic and Reconstructive Surgery in Personalized Medicine: 2nd Edition)
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12 pages, 2496 KiB  
Article
Interdisciplinary Treatment of Malignant Chest Wall Tumors
by Koblandy Khamitov, Wojciech Dudek, Andreas Arkudas, Mohamed Haj Khalaf, Chirag Parjiea, Mostafa Higaze, Raymund E. Horch and Horia Sirbu
J. Pers. Med. 2023, 13(9), 1405; https://doi.org/10.3390/jpm13091405 - 20 Sep 2023
Viewed by 1833
Abstract
Background: Chest wall resections for malignant chest wall tumors (MCWTs), particularly those with full-thickness chest wall involvement requiring reconstruction, present a therapeutic challenge for thoracic and plastic reconstructive surgeons. The purpose of this study was to review our experience with chest wall resection [...] Read more.
Background: Chest wall resections for malignant chest wall tumors (MCWTs), particularly those with full-thickness chest wall involvement requiring reconstruction, present a therapeutic challenge for thoracic and plastic reconstructive surgeons. The purpose of this study was to review our experience with chest wall resection for primary and metastatic MCWTs, with a focus on perioperative outcomes and postoperative overall survival (OS). Methods: All patients who underwent surgical resection for primary and secondary MCWTs at our single institution between 2000 and 2019 were retrospectively analyzed. Results: A total of 42 patients (25 male, median age 60 years) operated upon with curative (n = 37, 88.1%) or palliative (n = 5, 11.9%) intent were reviewed. Some 33 (78%) MCWTs were of secondary origin. Chest wall reconstruction was required in 40 (95%) cases. A total of 13 (31%) patients had postoperative complications and one (2.3%) died perioperatively. The 5-year postoperative overall survival rate was 51.9%. The postoperative 5-year survival rate of 42.6% in patients with secondary MCWTs was significantly lower compared to the figure of 87.5% in patients with primary MCWTs. Conclusions: In well-selected patients, chest wall resections for primary and secondary MCWTs are feasible and associated with good perioperative outcomes. For secondary MCWTs, surgery can also be performed with palliative intent. Full article
(This article belongs to the Special Issue Plastic and Reconstructive Surgery in Personalized Medicine: 2nd Edition)
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