Neural Stem Cells for Modeling Neurological Diseases
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 287
Special Issue Editors
Interests: genetic control of neural crest formation, delamination and migration; live cell imaging of neural crest migratory behavior; molecular mechanisms of melanoma metastasis and drug resistance; modelling neurological diseases by cellular reprogramming
Interests: cell biology and biochemistry; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neural stem cells (NSCs) hold immense potential for advancing our understanding and treatment of neurological diseases. Their ability to self-renew, differentiate into various neural cell types, and recapitulate disease-specific phenotypes makes invaluable tools for use in disease modeling. This multidisciplinary frontier involves utilizing NSCs obtained from diverse sources, including embryonic stem cells, induced pluripotent stem cells, and adult neural tissues, to replicate the complexity of neurological disorders in vitro. By manipulating NSCs, researchers can generate three-dimensional organoids or two-dimensional culture systems that mimic the characteristics of neurodegenerative diseases, neurodevelopmental disorders, and other conditions affecting the nervous system. These NSC-based models enable the investigation of disease mechanisms, drug screening, and the development of personalized therapies. Furthermore, NSCs can be genetically modified to express disease-specific mutations, providing a powerful platform for understanding the molecular and cellular basis of various neurological conditions. This Special Issue illuminates recent advancements in NSCs utilization to model neurological diseases, highlighting their potential to unravel disease pathogenesis and facilitate the development of new therapeutic strategies.
Dr. Martin Cheung
Dr. Huseyin Sumer
Guest Editors
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Keywords
- neural stem cells
- neurological diseases
- disease modeling
- neurodegenerative disorders
- neurodevelopmental disorders
- in vitro models
- organoids
- drug screening
- personalized therapies
- disease mechanisms
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