3D Bioprinting for Tissue Engineering and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (18 June 2021) | Viewed by 14717

Special Issue Editor


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Guest Editor
Institute of Biomedical Engineering, Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal; Principal Investigator at Research Center of Sainte-Justine University Hospital Center; TransMedTech Research Chair in 3D Bioprinting and Regenerative Medicine, Montreal, QC, Canada
Interests: tissue and organ printing; tissue engineering; regenerative medicine; biomaterials; organ-on-a-chip; translation; regulation and standardization

Special Issue Information

Dear Colleagues,

The emergence of 3D bioprinting technology in tissue engineering and regenerative medicine has shown great promise in recent years that represents a significant advancement in reverse engineering artificial tissues and organs. This state-of-the-art technology involves the layer-by-layer positioning of living human cells and growth factors with biomaterials (i.e., bioinks) for fabricating complex functional tissues and organs. This versatile technology has already shown enormous progress for the generation and transplantation of miniaturized tissues and creating 3D in vitro models for drug discovery and screening applications. However, there are still many technical and translational challenges that need to be addressed. These include the development of biocompatible bioinks, the vascularization of tissues, and the resolution of 3D bioprinters, among others. This Special Issue will cover recent and innovative advances in the 3D bioprinting of tissues and organs, including methodologies, bioink development, applications, technical and translational challenges, regulatory pathways and standardization, and future developments.

Assist. Prof. Houman Savoji
Guest Editor

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Keywords

  • 3D bioprinting 
  • Tissue and organ printing
  • Tissue engineering
  • Regenerative medicine
  • Bioinks
  • Stem cells
  • Vascularization
  • Structure–function 
  • Translation
  • Regulation and standardization

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Published Papers (1 paper)

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Review

19 pages, 938 KiB  
Review
Natural Biomaterials and Their Use as Bioinks for Printing Tissues
by Claire Benwood, Josie Chrenek, Rebecca L. Kirsch, Nadia Z. Masri, Hannah Richards, Kyra Teetzen and Stephanie M. Willerth
Bioengineering 2021, 8(2), 27; https://doi.org/10.3390/bioengineering8020027 - 20 Feb 2021
Cited by 135 | Viewed by 13365
Abstract
The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natural bioinks. This paper reviews natural bioinks and [...] Read more.
The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natural bioinks. This paper reviews natural bioinks and their properties and functions in hard and soft tissue engineering applications. It discusses agarose, alginate, cellulose, chitosan, collagen, decellularized extracellular matrix, dextran, fibrin, gelatin, gellan gum, hyaluronic acid, Matrigel, and silk. Multi-component bioinks are considered as a way to address the shortfalls of individual biomaterials. The mechanical, rheological, and cross-linking properties along with the cytocompatibility, cell viability, and printability of the bioinks are detailed as well. Future avenues for research into natural bioinks are then presented. Full article
(This article belongs to the Special Issue 3D Bioprinting for Tissue Engineering and Regenerative Medicine)
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