New Sight of Biomaterials and Tissue Regeneration in Medicine Research: Updates and Future Direction

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 5255

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UCLA School of Dentistry,10833 Le Conte Ave.Box 951668, Los Angeles, CA 90095-1668, USA
Interests: biomaterials; microbiology; nano-materials; nanotechnologies; regeneration medicine; stem cell; tissue engineering
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Special Issue Information

Dear Colleagues, 

The journal Bioengineering would like to compile a collection of papers to report on advancements in the field of biomaterials and tissue regeneration.

A biomaterial is a substance that has been engineered to interact with biological systems for a medical purpose. Tissue regeneration includes regeneration of epithelial tissue, regeneration of fibrous tissue, regeneration of cartilage tissue and bone tissue, regeneration of blood vessels, regeneration of muscle tissue, and regeneration of nerve tissue. The main goal of tissue regeneration is to restore the morphological and functional features of tissue after an injury. As a hot topic in clinical research, tissue regeneration is expected to be used in the treatment of many damaging diseases in tissues. The aim of this Special Issue, entitled “New sight of biomaterials and tissue regeneration in medicine research: Updates and future directions”, is to make relevant work known to our colleagues in the field. To achieve this, the Special Issue, edited by Prof. Dr. Zhong Zheng, invites scientists to submit research articles, review articles, and short communications focused on this topic.

We look forward to your valuable contributions to make this Special Issue a reference resource for future researchers in the field of biomaterials and tissue regeneration.

Dr. Zhong Zheng
Guest Editor

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Published Papers (1 paper)

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Review

12 pages, 1051 KiB  
Review
Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool
by Amrendra Chaudhary, Poonam Kataria, Neha Surela and Jyoti Das
Bioengineering 2022, 9(6), 263; https://doi.org/10.3390/bioengineering9060263 - 20 Jun 2022
Cited by 6 | Viewed by 4762
Abstract
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy. Cerebral malaria is associated with multiple organ dysfunctions. The adhesion and accumulation of [...] Read more.
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy. Cerebral malaria is associated with multiple organ dysfunctions. The adhesion and accumulation of infected RBCs, platelets, and leucocytes (macrophages, CD4+ and CD8+ T cells, and monocytes) in the brain microvessels play an essential role in disease progression. Micro-vascular hindrance by coagulation and endothelial dysfunction contributes to neurological damage and the severity of the disease. Recent studies in human cerebral malaria and the murine model of cerebral malaria indicate that different pathogens as well as host-derived factors are involved in brain microvessel adhesion and coagulation that induces changes in vascular permeability and impairment of the blood-brain barrier. Efforts to alleviate blood-brain barrier dysfunction and de-sequestering of RBCs could serve as adjunct therapies. In this review, we briefly summarize the current understanding of the pathogenesis of cerebral malaria, the role of some factors (NK cells, platelet, ANG-2/ANG-1 ratio, and PfEMP1) in disease progression and various functions of Mesenchymal stem cells. This review also highlighted the implications of MSCs as a regenerative medicine. Full article
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