Matrix Metalloproteinases in Tissue Remodeling in Normal and Pathological Conditions
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 2695
Special Issue Editor
Interests: influence of selected xenobiotics and plant-origin compounds on the metabolism and functioning of the human body at the cellular level with the use of molecular biology methodology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Matrix metalloproteinases (MMPs) are a very important group of enzymes involved in the reconstruction of connective tissue, especially in the processes of protein degradation, including collagen. The family of metalloproteinases is divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type metalloproteinases, and other unclassified metalloproteinases. The activity of these enzymes is regulated at several levels. These include the stage of gene transcription, proteolytic activation of the zymogen, inhibition of enzymatic activity, degradation of metalloproteinases, and mRNA stability. Tissue inhibitors of metalloproteinases, TIMPs are endogenous inhibitors of metalloproteinases. Both MMP and TIMP play an important role in the organism under normal conditions and in pathological states. It is particularly important that they play an important role in all stages of cancer development: from initiation through development, metastasis to angiogenesis and apoptosis. As a result of matrix degradation, peptide growth factors are released. Metalloproteinases can also affect cell mobility by degrading E-cadherins and by regulating signals sent by integrins. The role of MMPs in supporting the development of cancer, and in particular in the formation of metastasis, is to facilitate the epithelial to mesenchymal transition and passage through the blood vessels. In the process of angiogenesis, they release angiogenic factors and degrade the ECM. On the other hand, MMPs can inhibit the growth of tumors. Therefore, both MMP and TIMP are intensively researched as potential anticancer drugs. The aim of this Special Issue is to collect information regarding matrix metalloproteinases, their structure, their activity, molecular mechanisms of their action, their influence on carcinogenesis and metastasis and their role in normal metabolism. This collection of articles will include the most relevant work in the area of matrix metalloproteinases in normal and pathological conditions with the use of the latest methodologies applied. Therefore, this Special Issue is open to comprehensive review and original research papers and addresses the following topics:
- Matrix metalloproteinases’ structure and activity
- Matrix metalloproteinases in normal and pathological conditions
- MMP role in cancer development
- TIMP role in cancer development
- MMP and TIMP as a target for new anticancer drug biosynthesis
Dr. Agata Jabłońska-Trypuć
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- matrix metalloproteinases
- cancer
- apoptosis
- angiogenesis
- metastasis
- MMP
- TIMP
- ECM
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
