Regenerative Biology: Regeneration After Spinal Cord and Peripheral Nerve Injury
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 68
Special Issue Editor
Interests: degenerative processes; motoneurons; tissue engineering; stem cells
Special Issue Information
Dear Colleagues,
Due to the complex nature of neuronal damage and the challenges associated with regeneration, injuries to the spinal cord and peripheral nerves often result in a series of deficits that are difficult to overcome, leaving patients to endure paralysis and neuropathic pain with limited prospects for recovery. Although peripheral nerve injuries are more quickly repaired and regeneration of axons in the peripheral nervous system (PNS) is possible, full recovery of function, including reflexes and motor coordination, is not expected. In contrast, spinal cord injuries are much more severe in terms of neuronal loss and inflammation in the central nervous system (CNS), which in turn may require complex interventions to mitigate degeneration and stimulate plasticity and recovery of affected neuronal and glial elements.
This Special Issue aims to explore the fundamental biological mechanisms underlying nerve regeneration and to elucidate the molecular and cellular pathways that govern repair processes in both the PNS and CNS. By advancing our understanding of these biological processes, we can pave the way for developing more effective strategies for promoting neuronal recovery. We particularly welcome contributions that offer novel insights into the cellular responses, signaling pathways, and genetic factors involved in regeneration, as well as studies utilizing animal models to investigate these processes. These approaches hold the potential to significantly inform future therapeutic strategies.
Prof. Dr. Alexandre Leite Rodrigues de Oliveira
Guest Editor
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Keywords
- neuronal regeneration
- peripheral nerve repair
- spinal cord injury
- axonal growth
- neuroplasticity
- glial cells
- molecular signaling pathways
- stem cells in nerve regeneration
- neuroinflammation
- animal models of nerve injury
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