DNA Codes beyond the Nucleotide Sequence
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 535
Special Issue Editor
Interests: DNA methylation, epigenetics; gene expression; molecular biology; sequencing; DNA; cloning; PCR; RNA; DNA sequencing; gel electrophoresis; electrophoresis
Special Issue Information
Dear Colleagues,
Deoxyribonucleic acid (DNA), the most famous biological molecule and the code for all of life on Earth, is a bundle of molecules located inside the cells of every living thing. Seventy years after the discovery of its double-helical structure, it is still remarkable that this deceptively simple molecule determines virtually everything about the form and function of all cells and organisms. Nucleotide sequences carry many kinds of genetic information; in addition to instructions for protein synthesis (triplet code, also known as genetic code), several codes are encoded from nucleotide sequences, including the structural shape code for DNA recognition; the chromatin code, which provides instructions on the appropriate placement of nucleosomes and their spatial arrangement along DNA molecules; the epigenetic codes; and the putative loop code for single-stranded RNA–protein interactions. Genomic function is determined by a combination of the DNA nucleotide sequence and the molecular mechanisms controlling access to genetic information in a highly condensed structure called chromatin. Therefore, the cellular enzymatic machinery responsible for DNA replication, recombination, and repair must circumvent this natural barrier to gain access to the DNA. Access to DNA can be determined by the interpretation of covalent modifications that influence the packaging of DNA into chromatin, including DNA methylation and histone modifications.
This issue will focus on recent data that suggest a regulatory role of the epigenetic code in DNA repair processes and a potential epigenetic histone code for these processes, and aims to present new technologies and strategies to elucidate the putative epigenetic code for each DNA repair process.
Dr. Rosanna del Gaudio
Guest Editor
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Keywords
- epigenetic code
- epigenetic code in DNA repair
- DNA methylation
- genomic code
- chromatin structure
- chromatin code
- three-letter genetic code
- DNA shape
- genomic signature
- DNA codes
- non-coding
- protein-coding DNA
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