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Biomedicines
Special Issues
Sex Hormones and Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic...
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Sex Hormones and Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 639

Special Issue Editors

Dr. Renáta Szabó

E-Mail Website
Guest Editor
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Interests: reactive oxygen species; antioxidants; physical exercise; metabolic disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Denise Börzsei

E-Mail Website
Guest Editor
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Interests: cardiovascular diseases; physical exercise; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The purpose of this Special Issue is to examine sexual dimorphism in relation to cardiovascular diseases (CVDs) and to explore the complex interplay between sex hormone disorders and CVDs. Understanding sex hormone disorders associated with cardiovascular disease may improve our insights into cardiovascular disease’s pathogenesis, with potential to translate this into improved individualized care for men and women with or at risk of cardiovascular disease.

In this Special Issue, we welcome the submission of reviews, original research, short communications, as well as perspectives that cover but are not limited to the following topics:

  • Sexual dimorphism and CVDs.
  • Aging, sex hormones, and CVDs.
  • How sex steroids are beneficial or detrimental in CVDs.
  • Molecular mechanisms, unfavorable hormone profiles, and their interplay with CVDs.
  • Emerging drugs and biological agents aimed at hormonal imbalances.
  • Animal models for understanding the interplay between hormonal disturbances and CVDs.

Dr. Renáta Szabó
Dr. Denise Börzsei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endogenous sex hormones
  • aging
  • sexual dimorphism
  • hormone replacement therapy
  • CVDs
  • hypertension
  • myocardial infarction
  • atherosclerosis

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Published Papers (1 paper)

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Research

11 pages, 1166 KiB  
Article
A Retrospective Study in Trans Individuals Undergoing Gender Affirming Testosterone Treatment: Can Changes in Prolactin Counteract the Negative Effects on the Lipid Profile?
by Jojo Steininger, Katalin Widmann, Ulrike Kaufmann, Marlene Hager, Rodrig Marculescu, Robert Krysiak and Johannes Ott
Biomedicines 2025, 13(1), 66; https://doi.org/10.3390/biomedicines13010066 - 30 Dec 2024
Viewed by 429
Abstract
Background/Objectives: Gender-affirming hormone therapy (GAHT) is known to influence the lipid profiles of trans men and transmasculine individuals. Recent data show that moderate prolactin (PRL) elevations might exert beneficial metabolic effects (“HomeoFIT-PRL model”). The aim of this study is to investigate changes in [...] Read more.
Background/Objectives: Gender-affirming hormone therapy (GAHT) is known to influence the lipid profiles of trans men and transmasculine individuals. Recent data show that moderate prolactin (PRL) elevations might exert beneficial metabolic effects (“HomeoFIT-PRL model”). The aim of this study is to investigate changes in PRL levels and possible associations between PRL and lipid profiles in this population after a year of GAHT. Methods: In a retrospective cohort study, 97 participants, who received GAHT with testosterone, were included. Blood lipids, PRL, and sex steroid hormone levels were evaluated prior to and at 10–14 months after treatment started. Results: The difference in PRL levels between baseline and follow-up was significant (p = 0.007) with a median difference of +2.3 ng/mL. Concerning blood lipids, the decline in high-density lipoprotein cholesterol (HDL-C) reached statistical significance (median 56 mg/dL versus 50 mg/dL; p < 0.001), and low-density lipoprotein cholesterol (LDL-C) and triglyceride levels increased (p = 0.023 and p = 0.045, respectively). Individuals with a PRL > 25 ng/mL at follow-up (n = 20, 20.6%) revealed increases in total cholesterol and LDL-C significantly less often. Overall, participants frequently displayed unfavorable changes in their lipid profile after 10–14 months of GAHT, as well as a slight but significant increase in PRL. About 20% of patients showed mild-to-moderate hyperprolactinemia (PRL > 25 ng/mL). However, such changes were associated with potentially beneficial dynamics in the lipid profile, at least for triglycerides. Conclusions: These findings seem in line with the HomeoFIT-PRL model suggesting that moderate elevations in PRL levels might exert beneficial metabolic effects. Increases in PRL after testosterone were common. Full article
(This article belongs to the Special Issue Sex Hormones and Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches)
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