Diabetes Complications: From Pathophysiology to Novel Therapeutic Approaches 2.0
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 5580
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Special Issue “Diabetes Complications: From Pathophysiology to Novel Therapeutic Approaches 2.0” will focus on the molecular pathophysiology of diabetes mellitus and its devastating complications, as well as new biomarkers for early detection, and novel therapeutic approaches.
Diabetes mellitus has become an epidemic in recent decades. Worldwide, the data show a near quadrupling of the number of cases of diagnosed diabetes, from 108 million persons in 1980 to 425 million in 2017. There is a projected increase in the prevalence of diabetes up to 592 million (10.1%) by 2035. This increase mirrors the increasing prevalence of obesity in children and young adults, particularly those in highly susceptible ethnic groups. The long-term complications of T2DM cause a wide range of increasingly prevalent debilitating co-morbidities with complex pathophysiology in diabetic patients. Although the heritability of type 2 diabetes is high (30–70%) and more than 60 genetic variants related with diabetes risk have now been identified, the individual effects of genetic variants are modest, and even when combined into a genetic score, known genes contribute little to the prediction of diabetes. A more comprehensive understanding of the underlying molecular processes and the identification of key molecules could lead to a more precisely targeted intervention either for prevention or for treatment. Monitoring changes in the global gene expression profile, refined by global microRNA expression profiling, could provide the necessary clues to find these key components and biomarkers. This Special Issue invites original articles and reviews in basic, clinical, translational, and multidisciplinary research, including, but not limited to, the following diabetes-related topics:
- Cardiovascular disease;
- Hyperlipidemia;
- Neuropathy;
- Erectile dysfunction;
- Nephropathy;
- Retinopathy;
- Skin conditions;
- Impaired wound healing;
- Hearing impairment;
- Psychological effects.
Dr. Usama Elewa
Guest Editor
Manuscript Submission Information
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Keywords
- diabetes complications
- epigenetic imprinting
- molecular profiling
- biomarkers
- targeted therapy
- glucose control
- conventional and complementary approaches
- stem cell damage
- vascular damage and regeneration
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